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Pediatric Radiology

, Volume 45, Issue 5, pp 658–666 | Cite as

Spleen stiffness measurements by acoustic radiation force impulse imaging after living donor liver transplantation in children: a potential quantitative index for venous complications

  • Hirofumi Tomita
  • Yasushi FuchimotoEmail author
  • Kiyoshi Ohkuma
  • Ken Hoshino
  • Akihiro Fujino
  • Mototoshi Kato
  • Takumi Fujimura
  • Hideo Ishihama
  • Nobuhiro Takahashi
  • Yutaka Tanami
  • Seishi Nakatsuka
  • Hirotoshi Ebinuma
  • Hidetsugu Saito
  • Masahiro Shinoda
  • Yuko Kitagawa
  • Tatsuo Kuroda
Original Article

Abstract

Background

Living donor liver transplantation in children often results in venous complications, leading to portal hypertension. Spleen stiffness measurements have been recently proposed as a new, noninvasive parameter for portal hypertension in cirrhotic patients.

Objective

To evaluate the diagnostic value of spleen stiffness measurements by acoustic radiation force impulse (ARFI) imaging in diagnosing venous complications after pediatric living donor liver transplantation.

Materials and methods

We prospectively enrolled 69 patients after pediatric living donor liver transplantation using a left-side liver allograft. Around the time of the protocol liver biopsy examination, spleen stiffness measurements by ARFI imaging were performed via the left intercostal space at the center of the spleen parenchyma and repeated five times. Imaging examinations around the time of the spleen stiffness measurements were retrospectively reviewed. Regarding venous complications, significant portal and hepatic venous stenosis was defined as >50% stenosis on multiphasic computed tomography.

Results

After post hoc exclusion, 62 patients were studied. Portal and hepatic venous stenosis was identified in three and two patients, respectively. The median spleen stiffness values were 2.70 and 4.00 m/s in patients without and with venous complications, respectively (P < 0.001). Spleen stiffness measurements showed good diagnostic power for venous complications, and the cutoff value was determined as 2.93 m/s, with 100% sensitivity and 78.9% specificity. Spleen stiffness measurements decreased with the relief of venous stenosis resulting from an interventional radiology procedure.

Conclusion

Spleen stiffness measurements by ARFI imaging might provide a useful quantitative index for venous complications after pediatric living donor liver transplantation.

Keywords

Acoustic radiation force impulse imaging Living donor liver transplantation Child Portal hypertension Spleen stiffness measurement Complications 

Notes

Acknowledgments

The research presented in this manuscript was supported by the Japan Society for the Promotion of Science (JSPS KAKENHI, Grant-in-Aid for Young Scientists [B], Grant Number 26870570), and the authors have no conflicts of interest to disclose. The authors thank Mieko Tsuchida, Yuko Shirahata, Yoshiko Shiomi, Chigusa Mochizuki, Dr. Akihisa Ueno and Yuji Masuda for performing the measurements of spleen and liver stiffness by ARFI imaging.

Conflicts of interest

None

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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Hirofumi Tomita
    • 1
  • Yasushi Fuchimoto
    • 1
    • 2
    Email author
  • Kiyoshi Ohkuma
    • 3
  • Ken Hoshino
    • 1
  • Akihiro Fujino
    • 1
  • Mototoshi Kato
    • 1
  • Takumi Fujimura
    • 1
  • Hideo Ishihama
    • 1
  • Nobuhiro Takahashi
    • 1
  • Yutaka Tanami
    • 3
  • Seishi Nakatsuka
    • 3
  • Hirotoshi Ebinuma
    • 4
  • Hidetsugu Saito
    • 4
  • Masahiro Shinoda
    • 1
  • Yuko Kitagawa
    • 1
  • Tatsuo Kuroda
    • 1
  1. 1.Department of SurgeryKeio University School of MedicineTokyoJapan
  2. 2.Division of Surgery, Department of Surgical SubspecialtiesNational Center for Child Health and DevelopmentTokyoJapan
  3. 3.Department of RadiologyKeio University School of MedicineTokyoJapan
  4. 4.Department of MedicineKeio University School of MedicineTokyoJapan

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