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Pediatric Radiology

, Volume 45, Issue 1, pp 55–61 | Cite as

Acoustic radiation force impulse (ARFI) elastography for detection of renal damage in children

  • Cemil Göya
  • Cihad HamidiEmail author
  • Aydın Ece
  • Mehmet Hanifi Okur
  • Bekir Taşdemir
  • Mehmet Güli Çetinçakmak
  • Salih Hattapoğlu
  • Memik Teke
  • Cahit Şahin
Original Article

Abstract

Background

Acoustic radiation force impulse (ARFI) imaging is a promising method for noninvasive evaluation of the renal parenchyma.

Objective

To investigate the contribution of ARFI quantitative US elastography for the detection of renal damage in kidneys with and without vesicoureteral reflux (VUR).

Materials and methods

One hundred seventy-six kidneys of 88 children (46 male, 42 female) who had been referred for voiding cystourethrography and 20 healthy controls were prospectively investigated. Patients were assessed according to severity of renal damage on dimercaptosuccinic acid (DMSA) scintigraphy. Ninety-eight age- and gender-matched healthy children constituted the control group. Quantitative shear wave velocity (SWV) measurements were performed in the upper and lower poles and in the interpolar region of each kidney. DMSA scintigraphy was performed in 62 children (124 kidneys). Comparisons of SWV values of kidneys with and without renal damage and/or VUR were done.

Results

Significantly higher SWV values were found in non-damaged kidneys. Severely damaged kidneys had the lowest SWV values (P < 0.001). High-grade (grade V-IV) refluxing kidneys had the lowest SWV values, while non-refluxing kidneys had the highest values (P < 0.05). Significant negative correlations were found between the mean quantitative US elastography values and DMSA scarring score (r = −0.788, P < 0.001) and VUR grade (r = −0.634, P < 0.001). SWV values of the control kidneys were significantly higher than those of damaged kidneys (P < 0.05).

Conclusion

Our findings suggest decreasing SWV of renal units with increasing grades of vesicoureteric reflux, increasing DMSA-assessed renal damage and decreasing DMSA-assessed differential function.

Keywords

ARFI elastography Renal damage Vesicoureteral reflux DMSA scintigraphy Child 

Notes

Conflicts of interest

None

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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Cemil Göya
    • 1
  • Cihad Hamidi
    • 1
    Email author
  • Aydın Ece
    • 2
  • Mehmet Hanifi Okur
    • 3
  • Bekir Taşdemir
    • 4
  • Mehmet Güli Çetinçakmak
    • 1
  • Salih Hattapoğlu
    • 1
  • Memik Teke
    • 1
  • Cahit Şahin
    • 5
  1. 1.Department of Radiology Medical SchoolDicle UniversityDiyarbakirTurkey
  2. 2.Department of Pediatrics, Medical SchoolDiyarbakir UniversityDicleTurkey
  3. 3.Department of Pediatric Surgery, Medical SchoolDicle UniversityDiyarbakirTurkey
  4. 4.Department of Nuclear Medicine Medical SchoolDicle University DiyarbakirDiyarbakirTurkey
  5. 5.Department of Pediatrics, Medical SchoolDicle UniversityDiyarbakirTurkey

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