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Melanotic neuroectodermal tumour of infancy: CT and MR findings

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Abstract

Background

Melanotic neuroectodermal tumour of infancy (MNTI) is a rare neoplasm of neural crest origin.

Objective

To describe three further cases of MNTI, with emphasis on CT and MRI findings.

Materials and methods

Data for children with histologically confirmed MNTI following biopsy or surgery were retrieved. Three children with available imaging at the time of diagnosis were included in the study.

Results

All three children had primary tumour in the head and neck region: one in the maxilla, one in the occipital bone (extra-axial but with intracranial extension) and one with an unusual tumour growing exophytically from the subcutaneous tissues adjacent to the occipital bone. All tumours were iso/hypointense both on T1- and T2-weighted MRI, and showed marked contrast enhancement in their non-ossified components. CT allowed identification of bone destruction and remodelling.

Conclusion

Our findings are consistent with previously reported cases of MNTI regarding age at presentation and location in the head and neck region. Our MR findings did not demonstrate the typical pattern of T1-shortening expected from melanin deposition.

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References

  1. Nazira B, Gupta H, Chaturvedi AK et al (2009) Melanotic neuroectodermal tumour of infancy: a discussion of a case and a review of the imaging findings. Cancer Imaging 9:121–125

    PubMed  CAS  Google Scholar 

  2. Krompecher E (1918) Zur Histogenese und Morphologie der Adamantinome und sonstiger Kiefergeschwülste. Beitr Path Anat 64:165–197

    Google Scholar 

  3. Borello ED, Gorlin RJ (1966) Melanotic neuroectodermal tumor of infancy—a neoplasm of neural crese origin. Report of a case associated with high urinary excretion of vanilmandelic acid. Cancer 19:196–206

    Article  PubMed  CAS  Google Scholar 

  4. Cutler LS, Chaudhry AP, Topazian R (1981) Melanotic neuroectodermal tumor of infancy: an ultrastructural study, literature review, and reevaluation. Cancer 48:257–270

    Article  PubMed  CAS  Google Scholar 

  5. George JC, Edwards MK, Jakacki RI et al (1995) Melanotic neuroectodermal tumor of infancy. AJNR 16:1273–1275

    PubMed  CAS  Google Scholar 

  6. Kruse-Lösler B, Gaertner C, Bürger H et al (2006) Melanotic neuroectodermal tumor of infancy: systematic review of the literature and presentation of a case. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 102:204–216

    Article  PubMed  Google Scholar 

  7. Choi IS, Kook H, Dan DK et al (2007) Melanotic neuroectodermal tumor of infancy in the femur: a case report and review of the literature. J Pediatr Hematol Oncol 29:854–857

    Article  PubMed  Google Scholar 

  8. Carpenter BF, Jimenez C, Robb IA (1985) Melanotic neuroectodermal tumor of infancy. Pediatr Pathol 3:227–244

    Article  PubMed  CAS  Google Scholar 

  9. Fowler DJ, Chisholm J, Roebuck D et al (2006) Melanotic neuroectodermal tumor of infancy: clinical, radiological, and pathological features. Fetal Pediatr Pathol 25:59–72

    Article  PubMed  CAS  Google Scholar 

  10. Chossegros C, Cheynet F, Gentet F et al (1995) Melanotic neuroectodermal tumor in a young child. Arch Pediatr 2:545–547

    Article  PubMed  CAS  Google Scholar 

  11. Lacy SR, Kuhar M (2010) Melanotic neuroectodermal tumor of infancy presenting in the subcutaneous soft tissue of the thigh. Am J Dermatopathol 32:282–286

    PubMed  Google Scholar 

  12. Matsumoto M, Sakuma J, Suzuki K et al (2005) Melanotic neuroectodermal tumor of infancy in the skull: case report and review of the literature. Surg Neurol 63:275–280

    Article  PubMed  Google Scholar 

  13. Atkinson GO Jr, Davis PC, Patrick LE et al (1989) Melanotic neuroectodermal tumor of infancy: MR findings and a review of the literature. Pediatr Radiol 20:20–22

    Article  PubMed  Google Scholar 

  14. Koral K, Derinkuyu B, Timmons C et al (2010) Melanotic neuroectodermal tumor of infancy: report of one calvarial lesion with T1 shortening and one maxillary lesion. Clin Imaging 34:382–384

    Article  PubMed  Google Scholar 

  15. Nishio S, Morioka T, Murakami N et al (1999) Melanotic neuroectodermal tumour of infancy at the anterior fontanelle. Neuroradiology 41:202–204

    Article  PubMed  CAS  Google Scholar 

  16. Mirich DR, Blaser SI, Harwood-Nash DC et al (1991) Melanotic neuroectodermal tumor of infancy: clinical, radiologic, and pathologic findings in five cases. AJNR 12:689–697

    PubMed  CAS  Google Scholar 

  17. Gaiger de Oliveira M, Thompson LD, Chaves AC et al (2004) Management of melanotic neuroectodermal tumor of infancy. Ann Diagn Pathol 8:207–212

    Article  PubMed  Google Scholar 

  18. Woessmann W, Neugebauer M, Gossen R et al (2003) Successful chemotherapy for malignant neuroectodermal tumor of infancy. Med Pediatr Oncol 40:198–199

    Article  PubMed  Google Scholar 

  19. Kumari TP, Venugopal M, Mathews A et al (2005) Effectiveness of chemotherapy in melanotic neurectodermal tumor of infancy. Pediatr Hematol Oncol 22:199–206

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Radiology, Great Ormond Street Hospital, Great Ormond Street, London, WC1N 3JH, UK

    Saira Haque, Neil Sebire & Kieran McHugh

  2. St. Jude Children’s Research Hospital, Memphis, TN, USA

    Mary Beth McCarville

Authors
  1. Saira Haque
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  2. Mary Beth McCarville
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  3. Neil Sebire
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  4. Kieran McHugh
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Correspondence to Kieran McHugh.

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Haque, S., McCarville, M.B., Sebire, N. et al. Melanotic neuroectodermal tumour of infancy: CT and MR findings. Pediatr Radiol 42, 699–705 (2012). https://doi.org/10.1007/s00247-011-2339-1

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  • DOI: https://doi.org/10.1007/s00247-011-2339-1

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