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Novel use of F-DOPA PET/CT imaging in a child with paraganglioma/pheochromocytoma syndrome

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Abstract

We report the use of F-DOPA PET/CT imaging in the evaluation of a teenager with marked hypertension and right pararenal, left adrenal and left para-aortic mass lesions. The use of the modality for this clinical application has not been described previously within the pediatric imaging literature. The value of this technique relative to conventional imaging modalities is discussed and warrants consideration of its use, if available, for evaluating children with suspected paragangliomas/pheochromocytomas.

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References

  1. Muller U, Troidl C, Niemann S (2005) SDHC mutations in hereditary paraganglioma/pheochromocytoma. Fam Cancer 4:9–12

    Article  PubMed  Google Scholar 

  2. Rao AB, Koeller KK, Adair CF (1999) From the archives of the AFIP. Paragangliomas of the head and neck: radiologic-pathologic correlation. Armed Forces Institute of Pathology. Radiographics 19:1605–1632

    PubMed  CAS  Google Scholar 

  3. Badenhop RF, Cherian S, Lord RS et al (2001) Novel mutations in the SDHD gene in pedigrees with familial carotid body paraganglioma and sensorineural hearing loss. Genes Chromosomes Cancer 31:255–263

    Article  PubMed  CAS  Google Scholar 

  4. Imani F, Agopian VG, Auerbach MS et al (2009) 18F-FDOPA PET and PET/CT accurately localize pheochromocytomas. J Nucl Med 50:513–519

    Article  PubMed  Google Scholar 

  5. Wiseman GA, Pacak K, O’Dorisio MS et al (2009) Usefulness of 123I-MIBG scintigraphy in the evaluation of patients with known or suspected primary or metastatic pheochromocytoma or paraganglioma: results from a prospective multicenter trial. J Nucl Med 50:1448–1454

    Article  PubMed  CAS  Google Scholar 

  6. Brink I, Hoegerle S, Klisch J et al (2005) Imaging of pheochromocytoma and paraganglioma. Fam Cancer 4:61–68

    Article  PubMed  CAS  Google Scholar 

  7. Hoegerle S, Nitzsche E, Altehoefer C et al (2002) Pheochromocytomas: detection with 18F DOPA whole body PET–initial results. Radiology 222:507–512

    Article  PubMed  Google Scholar 

  8. Imani F, Agopian VG, Auerbach MS et al (2009) 18F-FDOPA PET and PET/CT accurately localize pheochromocytomas. J Nucl Med 50:513–519

    Article  PubMed  Google Scholar 

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Acknowledgement

The authors wish to thank Ms. J. Leggett, chief nuclear medicine technologist at British Columbia Children’s Hospital, for her help with image processing.

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Correspondence to Daniel S. Levine.

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Levine, D.S., Metzger, D.L., Nadel, H.R. et al. Novel use of F-DOPA PET/CT imaging in a child with paraganglioma/pheochromocytoma syndrome. Pediatr Radiol 41, 1321–1325 (2011). https://doi.org/10.1007/s00247-011-2109-0

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  • DOI: https://doi.org/10.1007/s00247-011-2109-0

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