Abstract
We report a symptomatic girl with reversible circumscribed cytotoxic oedema in the splenium of the corpus callosum (CC) that occurred, to our knowledge, for the first time in relation to tetracycline treatment. After stopping tetracycline therapy the girl recovered completely and the CC lesion, clearly visible on diffusion-weighted MR imaging (DWI), disappeared. Reversible circumscribed cytotoxic oedema (CCO) of the splenium of the CC is a well-defined entity that is found to be associated with administration of antiepileptic drugs, alterations in therapy using arginin-vasopressin and metronidazole or infections with influenza and rotavirus. CCO of splenium of the CC is clearly visible on DWI, shows no enhancement after administration of contrast medium and is completely reversible in most cases.
References
Prilipko O, Delavelle J, Lazeyras F et al (2005) Reversible cytotoxic edema in the splenium of the corpus callosum related to antiepileptic treatment: report of two cases and literature review. Epilepsia 46:1633–1636
Tsuji M, Yoshida T, Miyakoshi C et al (2009) Is a reversible splenal lesion a sign of encephalopathy? Pediatr Neurol 41:143–145
Takanashi J, Barkovich AJ, Yamagushi K et al (2004) Influenza-associated encephalitis/encephalopathy with a reversible lesion in the splenium of the corpus callosum: a case report and literature review. AJNR 25:798–802
Kobata R, Tsukahara H, Nakai A et al (2002) Transient MR signal changes in the splenium of the corpus callosum in rotavirus encephalopathy: value of diffusion-weighted imaging. J Comput Assist Tomogr 26:825–828
Kim E, Na DG, Kim EY et al (2007) MR imaging of metronidazole-induced encephalopathy: lesion distribution and diffusion-weighted imaging findings. AJNR 28:1652–1658
Gallucci M, Limbucci N, Paonessa A et al (2007) Reversible focal splenial lesions. Neuroradiology 49:541–544
Smith K, Leyden JJ (2005) Safety of doxycycline and minocycline: a systematic review. Clin Ther 27:1329–1342
Simon C, Malerczyk V, Preuss I et al (1976) Activity in vitro and pharmacokinetics of minocycline (author’s translation). Arzneimittelforschung 26:556–560
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Grühbaum, B., Salzer, H., Nasel, C. et al. Reversible cytotoxic oedema in the splenium of the corpus callosum related to tetracycline therapy. Pediatr Radiol 40, 1693–1695 (2010). https://doi.org/10.1007/s00247-010-1745-0
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00247-010-1745-0