Abstract
Vascular tumours and malformations, fibrous and fibrohistiocytic tumours and pseudotumours are the most common benign soft-tissue masses observed in children, and can be treated conservatively. Rhabdomyosarcomas are the most frequent malignant tumours, accounting for about half of soft tissue sarcomas. A child referred for a soft-tissue mass should ideally be managed by a multidisciplinary team and primary excision should be proscribed until a definite diagnosis has been established. Clinical examination, conventional radiography and US with Doppler represent the first-line examinations and are sometimes sufficient to make a diagnosis. In all other situations, MRI is mandatory to establish the aggressiveness and extension of the tumour. This technique provides the relevant data to guide the decision regarding tissue sampling.
Similar content being viewed by others
References
Dubois J, Garel L (1999) Imaging and therapeutic approach of hemangiomas and vascular malformations in the pediatric age group. Pediatr Radiol 29:879–893
Enzinger FM, Weiss SW (1995) Soft tissue tumors. Mosby, St. Louis
Carli M, Cecchetto G, Sotti G et al (2004) Soft tissue sarcomas. In: Pinkerton CR, Plowman PN, Pieters R (eds) Paediatric oncology. Hodder Arnold, London, pp 339–370
Stevens M (1998) Rhabdomyosarcoma. In: Voute A, Kalifa C, Barrett A (eds) Cancer in children: clinical management, 3rd edn. Oxford University Press, USA
McCarville MB, Spunt SL, Pappo AS (2001) Rhabdomyosarcoma in pediatric patients: the good, the bad, and the unusual. AJR 176:1563–1569
Fletcher CDM, Unni KK, Mertens F (2002) Pathology and genetics of tumours of soft tissue and bone. World Health Organisation classification of tumours. International Agency for Research on Cancer, Lyon
Delattre O, Michon J, Peter M et al (1997) New biological prognostic factors of soft tissue sarcoma. SFOP (Societe francaise d’oncologie pediatrique). Cancer Radiother 1:448–452
Kransdorf MJ, Murphey MD (2000) Radiologic evaluation of soft-tissue masses: a current perspective. AJR 175:575–587
Laor T (2004) MR imaging of soft tissue tumors and tumor-like lesions. Pediatr Radiol 34:24–37
De Schepper AM, De Beuckeleer L, Vandevenne J et al (2000) Magnetic resonance imaging of soft tissue tumors. Eur Radiol 10:213–223
Brisse H, Orbach D, Klijanienko J et al (2006) Imaging and diagnostic strategy of soft tissue tumors in children. Eur Radiol 16:1147–1164
Laffan EE, Ngan BY, Navarro OM (2009) Pediatric soft-tissue tumors and pseudotumors: MR imaging features with pathologic correlation: part 2. Tumors of fibroblastic/myofibroblastic, so-called fibrohistiocytic, muscular, lymphomatous, neurogenic, hair matrix, and uncertain origin. Radiographics 29:e36
Van Rijn RR, Wilde JC, Bras J et al (2008) Imaging findings in noncraniofacial childhood rhabdomyosarcoma. Pediatr Radiol 38:617–634
Park K, van Rijn R, McHugh K (2008) The role of radiology in paediatric soft tissue sarcomas. Cancer Imaging 8:102–115
Beaman FD, Kransdorf MJ, Andrews TR et al (2007) Superficial soft-tissue masses: analysis, diagnosis, and differential considerations. Radiographics 27:509–523
Murphey MD, Carroll JF, Flemming DJ et al (2004) From the archives of the AFIP: benign musculoskeletal lipomatous lesions. Radiographics 24:1433–1466
McHugh K, Boothroyd AE (1999) The role of radiology in childhood rhabdomyosarcoma. Clin Radiol 54:2–10
Navarro OM, Laffan EE, Ngan BY (2009) Pediatric soft-tissue tumors and pseudo-tumors: MR imaging features with pathologic correlation: part 1. Imaging approach, pseudotumors, vascular Lesions, and adipocytic tumors. Radiographics 29:887–906
De Schepper AM, De Beuckeleer L, Vandevenne J (2001) Soft tissue tumors in pediatric patients. In: De Schepper AM (ed) Imaging of soft tissue tumors. Springer-Verlag, Heidelberg, pp 433–452
Kransdorf MJ, Murphey MD (2006) Imaging of soft tissue tumors, 2nd edn. Lippincott Williams and Wilkins, Philadelphia
Kransdorf MJ (1995) Benign soft-tissue tumors in a large referral population: distribution of specific diagnoses by age, sex, and location. AJR 164:395–402
Kransdorf MJ (1995) Malignant soft-tissue tumors in a large referral population: distribution of diagnoses by age, sex, and location. AJR 164:129–134
Imhof H, Czerny C, Hormann M et al (2004) Tumors and tumor-like lesions of the neck: from childhood to adult. Eur Radiol 14:L155–L165
Tateishi U, Gladish GW, Kusumoto M et al (2003) Chest wall tumors: radiologic findings and pathologic correlation: part 1. Benign tumors. Radiographics 23:1477–1490
Tateishi U, Gladish GW, Kusumoto M et al (2003) Chest wall tumors: radiologic findings and pathologic correlation: part 2. Malignant tumors. Radiographics 23:1491–1508
Murphey MD, Gibson MS, Jennings BT et al (2006) From the archives of the AFIP: imaging of synovial sarcoma with radiologic-pathologic correlation. Radiographics 26:1543–1565
Robbin MR, Murphey MD, Temple HT et al (2001) Imaging of musculoskeletal fibromatosis. Radiographics 21:585–600
Chung S, Frush DP, Prose NS et al (1999) Subcutaneous granuloma annulare: MR imaging features in six children and literature review. Radiology 210:845–849
Bhargava R, Parham DM, Lasater OE et al (1997) MR imaging differentiation of benign and malignant peripheral nerve sheath tumors: use of the target sign. Pediatr Radiol 27:124–129
Murphey MD, Smith WS, Smith SE et al (1999) From the archives of the AFIP. Imaging of musculoskeletal neurogenic tumors: radiologic-pathologic correlation. Radiographics 19:1253–1280
Torreggiani WC, Al-Ismail K, Munk PL et al (2002) Dermatofibrosarcoma protuberans: MR imaging features. AJR 178:989–993
Hoffmann V, Roeren T, Moller P et al (1998) MR imaging of a pilomatrixoma. Pediatr Radiol 28:272
Ferrari A, Bisogno G, Macaluso A et al (2007) Soft-tissue sarcomas in children and adolescents with neurofibromatosis type 1. Cancer 109:1406–1412
Johnson CJ, Pynsent PB, Grimer RJ (2001) Clinical features of soft tissue sarcomas. Ann R Coll Surg Engl 83:203–205
Brisse H, McHugh K, Scaramuzza D (2005) RMS and non-RMS soft tissue sarcomas. Radiological guidelines. In: EpSSG RMS and NRSTS therapeutic protocols. Available at http://www.espr.org/index.php?option=com_content&task=view&id=39&Itemid=39
Reiseter T, Nordshus T, Borthne A et al (1999) Lipoblastoma: MRI appearances of a rare paediatric soft tissue tumour. Pediatr Radiol 29:542–545
Siegel MJ (2001) Magnetic resonance imaging of musculoskeletal soft tissue masses. Radiol Clin North Am 39:701–720
Shapeero LG, Vanel D, Verstraete KL et al (2002) Fast magnetic resonance imaging with contrast for soft tissue sarcoma viability. Clin Orthop Relat Res 397:212–227
van Rijswijk CS, Kunz P, Hogendoorn PC et al (2002) Diffusion-weighted MRI in the characterization of soft-tissue tumors. J Magn Reson Imaging 15:302–307
Baur A, Huber A, Arbogast S et al (2001) Diffusion-weighted imaging of tumor recurrencies and posttherapeutical soft-tissue changes in humans. Eur Radiol 11:828–833
Einarsdottir H, Karlsson M, Wejde J et al (2004) Diffusion-weighted MRI of soft tissue tumours. Eur Radiol 14:959–963
Berquist TH, Dalinka MK, Alazraki N et al (2000) Soft tissue masses. American College of Radiology. ACR appropriateness criteria. Radiology 215:255–259
Kransdorf MJ, Meis JM, Jelinek JS (1991) Myositis ossificans: MR appearance with radiologic-pathologic correlation. AJR 157:1243–1248
Ha TV, Kleinman PK, Fraire A et al (1994) MR imaging of benign fatty tumors in children: report of four cases and review of the literature. Skeletal Radiol 23:361–367
Berquist TH, Ehman RL, King BF et al (1990) Value of MR imaging in differentiating benign from malignant soft-tissue masses: study of 95 lesions. AJR 155:1251–1255
Narvaez JA, Narvaez J, Aguilera C et al (2001) MR imaging of synovial tumors and tumor-like lesions. Eur Radiol 11:2549–2560
Sung MS, Kang HS, Suh JS et al (2000) Myxoid liposarcoma: appearance at MR imaging with histologic correlation. Radiographics 20:1007–1019
Teo EL, Strouse PJ, Hernandez RJ (2000) MR imaging differentiation of soft-tissue hemangiomas from malignant soft-tissue masses. AJR 174:1623–1628
Kingston CA, Owens CM, Jeanes A et al (2002) Imaging of desmoid fibromatosis in pediatric patients. AJR 178:191–199
Pang LM, Roebuck DJ, Griffith JF et al (2001) Alveolar soft-part sarcoma: a rare soft-tissue malignancy with distinctive clinical and radiological features. Pediatr Radiol 31:196–199
Bodner G, Schocke MF, Rachbauer F et al (2002) Differentiation of malignant and benign musculoskeletal tumors: combined color and power Doppler US and spectral wave analysis. Radiology 223:410–416
Belli P, Costantini M, Mirk P et al (2000) Role of color Doppler sonography in the assessment of musculoskeletal soft tissue masses. J Ultrasound Med 19:823–830
Crim JR, Seeger LL, Yao L et al (1992) Diagnosis of soft-tissue masses with MR imaging: can benign masses be differentiated from malignant ones? Radiology 185:581–586
Moulton JS, Blebea JS, Dunco DM et al (1995) MR imaging of soft-tissue masses: diagnostic efficacy and value of distinguishing between benign and malignant lesions. AJR 164:1191–1199
Gielen JL, De Schepper AM, Vanhoenacker F et al (2004) Accuracy of MRI in characterization of soft tissue tumors and tumor-like lesions. A prospective study in 548 patients. Eur Radiol 14:2320–2330
Tung GA, Davis LM (1993) The role of magnetic resonance imaging in the evaluation of the soft tissue mass. Crit Rev Diagn Imaging 34:239–308
De Schepper AM, Ramon FA, Degryse HR (1992) Statistical analysis of MRI parameters predicting malignancy in 141 soft tissue masses. Rofo 156:587–591
Ma LD, Frassica FJ, McCarthy EF et al (1997) Benign and malignant musculoskeletal masses: MR imaging differentiation with rim-to-center differential enhancement ratios. Radiology 202:739–744
Eich GF, Hoeffel JC, Tschappeler H et al (1998) Fibrous tumours in children: imaging features of a heterogeneous group of disorders. Pediatr Radiol 28:500–509
Verstraete KL, Lang P (2000) Bone and soft tissue tumors: the role of contrast agents for MR imaging. Eur J Radiol 34:229–246
van Rijswijk CS, Geirnaerdt MJ, Hogendoorn PC et al (2004) Soft-tissue tumors: value of static and dynamic gadopentetate dimeglumine-enhanced MR imaging in prediction of malignancy. Radiology 233:493–502
Anderson MW, Temple HT, Dussault RG et al (1999) Compartmental anatomy: relevance to staging and biopsy of musculoskeletal tumors. AJR 173:1663–1671
Toomayan GA, Robertson F, Major NM (2005) Lower extremity compartmental anatomy: clinical relevance to radiologists. Skeletal Radiol 34:307–313
Wakely PE Jr, Kardos TF, Frable WJ (1988) Application of fine needle aspiration biopsy to pediatrics. Hum Pathol 19:1383–1386
Costa MJ, Campman SC, Davis RL et al (1996) Fine-needle aspiration cytology of sarcoma: retrospective review of diagnostic utility and specificity. Diagn Cytopathol 15:23–32
Willen H, Akerman M, Carlen B (1995) Fine needle aspiration (FNA) in the diagnosis of soft tissue tumours; a review of 22 years experience. Cytopathology 6:236–247
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Brisse, H.J., Orbach, D. & Klijanienko, J. Soft tissue tumours: imaging strategy. Pediatr Radiol 40, 1019–1028 (2010). https://doi.org/10.1007/s00247-010-1592-z
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00247-010-1592-z