Abstract
We report a neonate with antenatal imaging features suggestive of CLOVES syndrome. Postnatal clinical and imaging findings confirmed the diagnosis, with the constellation of truncal overgrowth, cutaneous capillary malformation, lymphatic and musculoskeletal anomalies. The clinical, radiological and histopathological findings noted in this particular phenotype help differentiate it from other overgrowth syndromes with complex vascular anomalies.
References
Sapp JC, Turner JT, van de Kamp JM et al (2007) Newly delineated syndrome of congenital lipomatous overgrowth, vascular malformations, and epidermal nevi (CLOVE syndrome) in seven patients. Am J Med Genet A 143A:2944–2958
Alomari AI (2009) Characterization of a distinct syndrome that associates complex truncal overgrowth, vascular, and acral anomalies: a descriptive study of 18 cases of CLOVES syndrome. Clin Dysmorphol 18:1–7
Alomari AI (2009) CLOVE(S) syndrome: expanding the acronym. Am J Med Genet 149A:294
Happle R (1987) Lethal genes surviving by mosaicism: a possible explanation for sporadic birth defects involving the skin. J Am Acad Dermatol 16:899–906
Sigaudy S, Fredouille C, Gambarelli D et al (1998) Prenatal ultrasonographic findings in Proteus syndrome. Prenat Diagn 10:1091–1094
De Smet L, Fryns JP (1994) Proteus syndrome and unilateral congenital windblown hand deformity. Am J Med Genet 49:136
Goldstein I, Jakobi P, Shoshany G et al (1994) Late-onset isolated cystic hygroma: the obstetrical significance, management, and outcome. Prenat Diagn 14:757–761
Fryns JP (1995) Late-onset isolated cystic hygroma. A first clinical sign of Proteus syndrome. Prenat Diagn 15:96–97
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Fernandez-Pineda, I., Fajardo, M., Chaudry, G. et al. Perinatal clinical and imaging features of CLOVES syndrome. Pediatr Radiol 40, 1436–1439 (2010). https://doi.org/10.1007/s00247-010-1559-0
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DOI: https://doi.org/10.1007/s00247-010-1559-0