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Pediatric Radiology

, Volume 40, Issue 3, pp 326–339 | Cite as

The dentate nucleus in children: normal development and patterns of disease

  • Aoife McErleanEmail author
  • Khaled Abdalla
  • Veronica Donoghue
  • Stephanie Ryan
Pictorial Essay

Abstract

The dentate nuclei lie deep within the cerebellum and play a vital role in the pathways involved in fine motor control and coordination. They are susceptible to a variety of diseases. Some pathological processes preferentially affect the dentate nuclei, while concomitant basal ganglia or white matter involvement can be a striking finding in others. A familiarity with the normal appearance of the dentate nuclei at different ages in combination with the radiological distribution of pathology in the brain allows the paediatric radiologist to develop a logical approach to the interpretation of MR imaging of these deep cerebellar nuclei. In this article we review the normal appearance and MR features of the dentate nuclei, including changes that are seen with myelination. We describe the specific imaging characteristics of childhood diseases that involve the dentate nuclei, and develop a systematic approach to the differential diagnosis of dentate nucleus abnormalities on MR imaging.

Keywords

Cerebellar nuclei MRI Anatomy Cross-sectional Paediatrics Cerebellum Dentate 

References

  1. 1.
    Barkovich AJ (1998) MR of the normal neonatal brain: assessment of deep structures. AJNR 19:1397–1403PubMedGoogle Scholar
  2. 2.
    Kizildag B, Dusunceli E, Fitoz S et al (2005) The role of classic spin echo and FLAIR sequences for the evaluation of myelination in MR imaging. Diagn Interv Radiol 11:130–136PubMedGoogle Scholar
  3. 3.
    Valanne L, Ketonen L, Majander A et al (1998) Neuroradiologic findings in children with mitochondrial disorders. AJNR 19:369–377PubMedGoogle Scholar
  4. 4.
    Hendriksz CJ (2009) Inborn errors of metabolism for the diagnostic radiologist. Pediatr Radiol 39:211–220CrossRefPubMedGoogle Scholar
  5. 5.
    Finsterer J (2008) Leigh and Leigh-like syndrome in children and adults. Pediatr Neurol 39:223–235CrossRefPubMedGoogle Scholar
  6. 6.
    Lee HF, Tsai CR, Chi CS et al (2009) Leigh syndrome: clinical and neuroimaging follow-up. Pediatr Neurol 40:88–93CrossRefPubMedGoogle Scholar
  7. 7.
    Rossi A, Biancheri R, Bruno C et al (2003) Leigh Syndrome with COX Deficiency and SURF-1 gene mutations: MR imaging findings. AJNR 24:1188–1191PubMedGoogle Scholar
  8. 8.
    Twomey EL, Naughten ER, Donoghue VB et al (2003) Neuroimaging findings in glutaric aciduria type 1. Pediatr Radiol 33:823–830CrossRefPubMedGoogle Scholar
  9. 9.
    Oguz KK, Ozturk A, Cila A (2005) Diffusion-weighted MR imaging and MR spectroscopy in glutaric aciduria type 1. Neuroradiology 47:229–234CrossRefPubMedGoogle Scholar
  10. 10.
    Takanashi J, Fujii K, Sugita K et al (1999) Neuroradiologic findings in glutaric aciduria type II. Pediatr Neurol 20:142–145CrossRefPubMedGoogle Scholar
  11. 11.
    Topçu M, Erdem G, Saatçi I et al (1996) Clinical and magnetic resonance imaging features of L-2-hydroxyglutaric acidemia: report of three cases in comparison with Canavan disease. J Child Neurol 11:373–377CrossRefPubMedGoogle Scholar
  12. 12.
    Kara S, Sherr EH, Barkovich AJ (2008) Dilated perivascular spaces: an informative radiologic finding in Sanfilippo syndrome type A. Pediatr Neurol 38:363–366CrossRefPubMedGoogle Scholar
  13. 13.
    Aicardi J, Goutières F (1984) A progressive familial encephalopathy in infancy with calcifications of the basal ganglia and chronic cerebrospinal fluid lymphocytosis. Ann Neurol 15:49–54CrossRefPubMedGoogle Scholar
  14. 14.
    Uggetti C, La Piana R, Orcesi S et al (2009) Aicardi-Goutières syndrome: neuroradiologic findings and follow-up. AJNR 30:1971–1976PubMedGoogle Scholar
  15. 15.
    Choksi V, Hoeffner E, Karaarslan E et al (2003) Infantile Refsum disease: case report. AJNR 24:2082–2084PubMedGoogle Scholar
  16. 16.
    Di Rocco M, Biancheri R, Rossi A et al (2004) MRI in acute intermittent maple syrup urine disease. Neurology 63:1078PubMedGoogle Scholar
  17. 17.
    Patay Z (2005) Diffusion-weighted MR imaging in leukodystrophies. Eur Radiol 15:2284–2303CrossRefPubMedGoogle Scholar
  18. 18.
    Provenzale JM, Peddi S, Kurtzberg J et al (2009) Correlation of neurodevelopmental features and MRI findings in infantile Krabbe’s disease. AJR 192:59–65CrossRefPubMedGoogle Scholar
  19. 19.
    Nagar VA, Ursekar MA, Krishnan P et al (2006) Krabbe disease: unusual MRI findings. Pediatr Radiol 36:61–64CrossRefPubMedGoogle Scholar
  20. 20.
    Sener RN (2000) van der Knapp syndrome: MR imaging findings including FLAIR, diffusion imaging and proton MR spectroscopy. Eur Radiol 10:1452–1455CrossRefPubMedGoogle Scholar
  21. 21.
    van der Knaap MS, Smit LM, Barth PG et al (1997) Magnetic resonance imaging in classification of congenital muscular dystrophies with brain abnormalities. Ann Neurol 42:50–59CrossRefPubMedGoogle Scholar
  22. 22.
    Fulham MJ, Brooks RA, Hallett M et al (1992) Cerebellar diaschisis revisited: pontine hypometabolism and dentate sparing. Neurology 42:2267–2273PubMedGoogle Scholar
  23. 23.
    Huang BY, Castillo M (2008) Hypoxic-ischemic brain injury: imaging findings from birth to adulthood. Radiographics 28:417–439CrossRefPubMedGoogle Scholar
  24. 24.
    Baker LL, Stevenson DK, Enzmann DR (1988) End-stage periventricular leucomalacia: MR evaluation. Radiology 168:809–815PubMedGoogle Scholar
  25. 25.
    Baskin HJ, Hedlund G (2007) Neuroimaging of herpes infections in children. Pediatr Radiol 37:949–963CrossRefPubMedGoogle Scholar
  26. 26.
    Montenegro MA, Santos SL, Li LM et al (2002) Neuroimaging of acute cerebellitis. J Neuroimaging 12:72–74CrossRefPubMedGoogle Scholar
  27. 27.
    Prayer D, Grois N, Prosch H et al (2004) MR imaging presentation of intracranial disease associated with Langerhans cell histiocytosis. AJNR 25:880–891PubMedGoogle Scholar
  28. 28.
    Martin-Duverneuil N, Idbaih A, Hoang-Xuan K et al (2006) MRI features of neurodegenerative Langerhans cell histiocytosis. Eur Radiol 16:2074–2082CrossRefPubMedGoogle Scholar
  29. 29.
    Itoh T, Magnaldi S, White RM et al (1994) Neurofibromatosis type 1: the evolution of deep gray and white matter MR abnormalities. AJNR 15:1513–1519PubMedGoogle Scholar
  30. 30.
    Herron J, Darrah R, Quaghebeur G (2000) Intra-cranial manifestations of neurocutaneous syndromes. Clin Radiol 55:82–98CrossRefPubMedGoogle Scholar
  31. 31.
    Jacques C, Dietemann JL (2005) Imaging features of neurofibromatosis type 1. Neuroradiology 32:180–197CrossRefGoogle Scholar
  32. 32.
    Griffiths PD, Blaser S, Mukonoweshuro W et al (1999) Neurofibromatosis bright objects in children with Neurofibromatosis type 1: a proliferative potential? Pediatrics 104:e49CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Aoife McErlean
    • 1
    Email author
  • Khaled Abdalla
    • 1
  • Veronica Donoghue
    • 1
  • Stephanie Ryan
    • 1
  1. 1.Radiology DepartmentChildren’s University HospitalDublin 1Ireland

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