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Pediatric Radiology

, Volume 40, Issue 3, pp 366–370 | Cite as

Pulmonary blastoma in a neonate: a lesion distinct from pleuropulmonary blastoma with unique cytogenetic features

  • Melissa Reichman
  • Arzu Kovanlikaya
  • Susan Mathew
  • Debra Beneck
  • Paula W. BrillEmail author
Case Report

Abstract

Pulmonary blastoma is a rare malignant primary lung neoplasm typically seen in adults that accounts for 0.3–1.3% of lung malignancies. It has been categorized as a subtype of sarcomatoid carcinoma according to the current World Health Organization Classification of Lung Tumours and is distinct from the more common pediatric lung tumor pleuropulmonary blastoma. We report a case of neonatal pulmonary blastoma, illustrating the imaging characteristics of this rare tumor. The subject of pediatric lung masses is confusing because the terms pleuropulmonary blastoma and pulmonary blastoma have been used interchangeably in previously reported cases. We recommend use of the current WHO classification to differentiate these lesions as additional cases are described. Additionally, we discuss distinctive cytogenetic features of this case.

Keywords

Pulmonary blastoma Neonate Malignant Lung neoplasm t(11;19) translocation Radiograph CT 

References

  1. 1.
    Dishop MK, Kuruvilla S (2008) Primary and metastatic lung tumors in the pediatric population: a review and 25-year experience at a large children’s hospital. Arch Pathol Lab Med 132:1079–1103PubMedGoogle Scholar
  2. 2.
    Weldon C, Shamberger R (2008) Pediatric pulmonary tumors: primary and metastatic. Semin Pediatr Surg 17:17–29CrossRefPubMedGoogle Scholar
  3. 3.
    Cappuccino H, Heleotis T, Krumerman M (1995) Pulmonary blastoma as a unique cause of fatal respiratory distress in a newborn. J Pediatr Surg 30:886–888CrossRefPubMedGoogle Scholar
  4. 4.
    Travis W, Brambilla E, Müller-Hermelink K et al (eds) (2004) World Health Organization Classification of Tumours. Pathology and genetics. Tumours of the lung, pleura, thymus and heart. IARC, Lyon, pp 53–58Google Scholar
  5. 5.
    Nafafaa L, Donnelly L (2005) Imaging findings in pleuropulmonary blastoma. Pediatr Radiol 35:387–391CrossRefGoogle Scholar
  6. 6.
    Linman S, Altinok T, Topcu S et al (2006) Survival of biphasic pulmonary blastoma. Respir Med 100:1174–1179CrossRefGoogle Scholar
  7. 7.
    Walker R, Suvarna K, Matthews S (2005) Pulmonary blastoma: presentation of two atypical cases and review of the literature. Br J Radiol 78:437–440CrossRefPubMedGoogle Scholar
  8. 8.
    Boldrini R, Devito R, Diomedi-Camassei F et al (2005) Pulmonary blastomas of childhood: histologic, immunohistochemical, ultrastructural aspects and therapeutic considerations. Ultrastruct Pathol 29:493–501CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Melissa Reichman
    • 1
  • Arzu Kovanlikaya
    • 1
  • Susan Mathew
    • 2
  • Debra Beneck
    • 2
  • Paula W. Brill
    • 1
    Email author
  1. 1.Department of RadiologyWeill Cornell Medical College/New York Presbyterian HospitalNew YorkUSA
  2. 2.Department of PathologyWeill Cornell Medical College/New York Presbyterian HospitalNew YorkUSA

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