Abstract
We describe a case of rapidly progressive neonatal diffuse hepatic haemangioendotheliomas. The clinical picture was characterized by respiratory insufficiency due to gross abdominal enlargement, coagulopathy, and the development of cardiovascular insufficiency during the course of disease. Pharmacological, radiotherapeutic and endovascular treatment options all proved ineffective. We describe our own experience and the steps taken to treat this child. Unfortunately, the child died as a consequence of the disease. As cases like this are rare and are associated with severe morbidity and high mortality, more knowledge needs to be gained on infantile hepatic haemangioendotheliomas and their optimal treatment. The use of a web-based data registry could be beneficial.
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von Schweinitz D (2003) Neonatal liver tumours. Semin Neonatol 8:403–410
Christison-Lagay ER, Burrows PE, Alomari A et al (2007) Hepatic hemangiomas: subtype classification and development of a clinical practice algorithm and registry. J Pediatr Surg 42:62–68
Huang SA, Tu HM, Harney JW et al (2000) Severe hypothyroidism caused by type 3 iodothyronine deiodinase in infantile hemangiomas. N Engl J Med 343:185–189
Burrows PE (1991) Variations in the vascular supply to infantile hepatic hemangioendotheliomas. Radiology 181:631–632
Boechat MI, Kangarloo H, Ortega J et al (1988) Primary liver tumors in children: comparison of CT and MR imaging. Radiology 169:727–732
Kassarjian A, Dubois J, Burrows PE (2002) Angiographic classification of hepatic hemangiomas in infants. Radiology 222:693–698
Kassarjian A, Zurakowski D, Dubois J (2004) Infantile hepatic hemangiomas: clinical and imaging findings and their correlation with therapy. AJR 182:785–795
Draper H, Diamond IR, Temple M et al (2008) Multimodal management of endangering hepatic hemangioma: impact on transplant avoidance: a descriptive case series. J Pediatr Surg 43:120–126
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van der Meijs, B.B., Merks, J.H.M., de Haan, T.R. et al. Neonatal hepatic haemangioendothelioma: treatment options and dilemmas. Pediatr Radiol 39, 277–281 (2009). https://doi.org/10.1007/s00247-008-1073-9
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DOI: https://doi.org/10.1007/s00247-008-1073-9