Pediatric Radiology

, Volume 36, Issue 9, pp 959–964 | Cite as

Paediatric brain-stem gliomas: MRI, FDG-PET and histological grading correlation

  • Jong Won Kwon
  • In-One KimEmail author
  • Jung-Eun Cheon
  • Woo Sun Kim
  • Sung Gyu Moon
  • Tae Jung Kim
  • Je Geun Chi
  • Kyu-Chang Wang
  • June Key Chung
  • Kyung Mo Yeon
Original Article



MRI and FDG-PET may predict the histological grading of paediatric brain-stem gliomas.


To assess MRI findings and metabolic imaging using FDG-PET of brain-stem gliomas based on histological grading.

Materials and methods

Included in the study were 20 paediatric patients (age 3–14 years, mean 8.2 years) with brain-stem glioma (five glioblastomas, ten anaplastic astrocytomas and five low-grade astrocytomas). MR images were assessed for the anatomical site of tumour origin, focality, pattern of tumour growth, and enhancement.


All glioblastomas were located in the pons and showed diffuse pontine enlargement with focally exophytic features. Eight anaplastic astrocytomas were located in the pons and demonstrated diffuse pontine enlargement without exophytic features. Low-grade astrocytomas were located in the pons, midbrain or medulla and showed focally exophytic growth features and peripheral enhancement. In 12 patients in whom FDG-PET was undertaken, glioblastomas showed hypermetabolic or hypometabolic lesions, anaplastic astrocytomas showed no metabolic change or hypometabolic lesions and low-grade astrocytomas showed hypometabolism compared with the cerebellum.


MRI findings correlated well with histological grading of brain-stem gliomas and MRI may therefore predict the histological grading. FDG-PET may be helpful in differentiating between anaplastic astrocytoma and glioblastomas among high-grade tumours.


Brain stem Brain neoplasms MRI PET Children 


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Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • Jong Won Kwon
    • 1
  • In-One Kim
    • 1
    Email author
  • Jung-Eun Cheon
    • 1
  • Woo Sun Kim
    • 1
  • Sung Gyu Moon
    • 1
  • Tae Jung Kim
    • 1
  • Je Geun Chi
    • 2
  • Kyu-Chang Wang
    • 3
  • June Key Chung
    • 4
  • Kyung Mo Yeon
    • 1
  1. 1.Department of RadiologySeoul National University HospitalSeoulSouth Korea
  2. 2.Department of PathologySeoul National University College of MedicineSeoulSouth Korea
  3. 3.Department of NeurosurgerySeoul National University College of MedicineSeoulSouth Korea
  4. 4.Department of Nuclear MedicineSeoul National University College of MedicineSeoulSouth Korea

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