Skip to main content
SpringerLink
Log in

Renal cell carcinoma as a second malignant neoplasm in a patient with non-syndromic hemihypertrophy and previous Wilms tumor

  • Case Report
  • Published:
Pediatric Radiology Aims and scope Submit manuscript

Abstract

Survivors of childhood Wilms tumors are at an increased risk of second malignant neoplasms. Recently, it has been postulated that renal cell carcinoma is among the malignancies for which this population is at risk. We present the unique case of an adult Wilms tumor survivor with non-syndromic hemihypertrophy (NSHH) who developed renal cell carcinoma. This case highlights the need for close follow-up in two populations: adults who have survived Wilms tumor and those with NSHH.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. Breslow NE, Takashima JR, Whitton JA, et al (1995) Second malignant neoplasms following treatment for Wilms tumor: a report from the National Wilms Tumor Study Group. J Clin Oncol 13:1851–1859

    CAS  PubMed  Google Scholar 

  2. Carli M, Frascella E, Tournade MF, et al (1997) Second malignant neoplasms in patients treated on SIOP Wilms tumour studies and trials 1, 2, 5, and 6. Med Pediatr Oncol 29:239–244

    CAS  PubMed  Google Scholar 

  3. Cherullo EE, Ross JH, Kay R, et al (2001) Renal neoplasms in adult survivors of childhood Wilms tumor. J Urol 165:2013–2016 (see also discussion pp 2016–2017)

    CAS  PubMed  Google Scholar 

  4. Hoyme HE, Seaver LH, Jones KL, et al (1998) Isolated hemihyperplasia (hemihypertrophy): report of a prospective multicenter study of the incidence of neoplasia and review. Am J Med Genet 79:274–278

    CAS  PubMed  Google Scholar 

  5. Young JL Jr, Miller RW (1975) Incidence of malignant tumors in US children. J Pediatr 86:254–258

    PubMed  Google Scholar 

  6. Muscat JE, Hoffman D, Wynder EL (1995) The epidemiology of renal cell carcinoma. A second look. Cancer 75:2552–2557

    CAS  Google Scholar 

  7. Chow WH, Devesa SS, Warren JL (1999) Rising incidence of renal cell cancer in the United States. JAMA 281:1628–1631

    CAS  PubMed  Google Scholar 

  8. Ballock RT, Wiesner GL, Myers MT, et al (1997) Hemihypertrophy. Concepts and controversies. J Bone Joint Surg Am 79:1731–1738

    CAS  PubMed  Google Scholar 

  9. Oliver JH, Gluck G, Gledhill RB, et al (1978) Musculoskeletal deformities following treatment of Wilms tumor. CMAJ 119:459–464

    CAS  Google Scholar 

  10. Tomooka Y, Onitsuka H, Goya T, et al (1988) Congenital hemihypertrophy with adrenal adenoma and medullary sponge kidney. Br J Radiol 61:851–853

    CAS  PubMed  Google Scholar 

  11. Wiedemann HR (1983) Tumours and hemihypertrophy associated with Beckwith-Wiedemann syndrome. Eur J Pediatr 141:129–133

    Article  Google Scholar 

  12. Sotelo-Avila C, Gonzalez-Crussi F, Fowler JW, et al (1980) Complete and incomplete forms of Beckwith-Wiedemann syndrome: their oncogenic potential. J Pediatr 96:47–50

    CAS  PubMed  Google Scholar 

  13. Clericuzio CL, Johnson C (1995) Screening for Wilms tumor in high-risk individuals. Hematol Oncol Clin North Am 9:1253–1265

    CAS  PubMed  Google Scholar 

  14. Mark S, Clark OH, Kaplan RA (1994) A virilized patient with congenital hemihypertrophy. Postgrad Med J 70:752–755

    CAS  PubMed  Google Scholar 

  15. Parker L, Kollin J, Vicario D, et al (1992) Hemihypertrophy as possible sign of renal cell carcinoma. Urology 40:286–288

    CAS  PubMed  Google Scholar 

  16. Hennessy WT, Cromie WJ, Duckett JW (1981) Congenital hemihypertrophy and associated abdominal lesions. Urology 18:576–579

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Medical Imaging, Royal University Hospital, 103 Hospital Drive, Saskatoon, SK, S7N0W8, Canada

    Greg Kraushaar & Sheldon Wiebe

Authors
  1. Greg Kraushaar
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Sheldon Wiebe
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Greg Kraushaar.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kraushaar, G., Wiebe, S. Renal cell carcinoma as a second malignant neoplasm in a patient with non-syndromic hemihypertrophy and previous Wilms tumor. Pediatr Radiol 35, 1208–1211 (2005). https://doi.org/10.1007/s00247-005-1540-5

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00247-005-1540-5

Keywords

Search

Navigation