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Chemical shift imaging and localised magnetic resonance spectroscopy in full-term asphyxiated neonates

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Abstract

Background: Diagnosis of brain lesions after birth anoxia-ischemia is essential for appropriate management. Clinical evaluation is not sufficient. MRI has been proven to provide useful information. Objective: To compare abnormalities observed with MRI, including diffusion-weighted imaging (DWI), localised magnetic resonance spectroscopy (MRS) and chemical shift imaging (CSI) and correlate these findings with the clinical outcome. Materials and methods: Fourteen full-term neonates with birth asphyxia were studied. MRI, MRS and CSI were performed within the first 4 days of life. Results: Lesions observed with DWI were correlated with outcome, but the apparent diffusion coefficient (ADC) did improve diagnostic confidence. The mean value of Lac/Cr for the neonates with a favourable outcome was statically lower than for those who died (0.22 vs 1.04; P = 0.01). The same results were observed for the Lac/NAA ratio (0.21 vs 1.23; P = 0.01). Data obtained with localised MRS and CSI were correlated for the ratio N-acetyl-aspartate/choline, but not for the other metabolites. No correlation was found between the ADC values and the metabolite ratios. Conclusions: Combination of these techniques could be helpful in our understanding of the physiopathological events occurring in neonates with asphyxia.

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Authors and Affiliations

  1. Paediatric Intensive Care Unit, Children’s Hospital, Place Amélie Raba Léon, Bordeaux, 33076, France

    Olivier Brissaud

  2. Radiology Unit, Children’s Hospital, Bordeaux, France

    Jean-François Chateil, Martine Bordessoules & Muriel Brun

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  1. Olivier Brissaud
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  2. Jean-François Chateil
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  3. Martine Bordessoules
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  4. Muriel Brun
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Correspondence to Olivier Brissaud.

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Brissaud, O., Chateil, JF., Bordessoules, M. et al. Chemical shift imaging and localised magnetic resonance spectroscopy in full-term asphyxiated neonates. Pediatr Radiol 35, 998–1005 (2005). https://doi.org/10.1007/s00247-005-1524-5

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  • DOI: https://doi.org/10.1007/s00247-005-1524-5

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