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Bone mineralization in newborns whose mothers received magnesium sulphate for tocolysis of premature labour

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Abstract

Prolonged maternal magnesium sulphate infusion therapy for tocolysis of premature labour may result in secondary fetal hypermagnesaemia, which has been associated with bony abnormalities in the newborn. We report on four infants, members of two twin pregnancies, who were exposed to prolonged fetal hypermagnesaemia. Three of the infants, all appropriate for gestational age, showed abnormal radiological findings consisting of abnormal mineralisation of long-bone metaphyses owing to fetal hypermagnesaemia. The fourth infant, who was growth retarded, had normal bones. Intrauterine growth restriction appears to be protective against magnesium sulphate-induced abnormal bone mineralisation in the newborn.

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Authors and Affiliations

  1. Department of Pediatrics, American University of Beirut Medical Center, PO Box 11-0236, Beirut, Lebanon

    Shadi N. Malaeb, Adriana I. Rassi & Khalid A. Yunis

  2. Department of Diagnostic Radiology, American University of Beirut Medical Center, Beirut, Lebanon

    Maurice C. Haddad

  3. Department of Obstetrics and Gynecology, American University of Beirut Medical Center, Beirut, Lebanon

    Muhieddine A. Seoud

Authors
  1. Shadi N. Malaeb
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  2. Adriana I. Rassi
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  3. Maurice C. Haddad
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  4. Muhieddine A. Seoud
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  5. Khalid A. Yunis
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Corresponding author

Correspondence to Khalid A. Yunis.

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Malaeb, S.N., Rassi, A.I., Haddad, M.C. et al. Bone mineralization in newborns whose mothers received magnesium sulphate for tocolysis of premature labour. Pediatr Radiol 34, 384–386 (2004). https://doi.org/10.1007/s00247-004-1148-1

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  • DOI: https://doi.org/10.1007/s00247-004-1148-1

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