Kawasaki Disease Features and Myocarditis in a Patient with COVID-19


A 10-year-old male with prolonged fever, rash, and conjunctivitis presented to the emergency department with concern for Kawasaki disease, found to have myocarditis and PCR positive for SARS-CoV-2.


Despite the increasing prevalence and disease burden of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), there is limited understanding of the spectrum of pediatric presentations. Although prior reports have reported that over 90% of pediatric cases are asymptomatic, mild, or moderate [1], it is critically important for physicians to recognize the possibility of severe presentations in pediatric patients.


A 10-year-old healthy male presented with fever for 7 days, fatigue, diarrhea, cough, rash, and conjunctivitis. He had been evaluated 3 days prior with a nasal swab negative for SARS-CoV-2. In the interim period, he developed a dry cough, diarrhea, conjunctivitis and development of the rash. He was referred to the emergency department (ED) with concern for Kawasaki Disease (KD).

On arrival to the ED, the temperature was 40.2 °C, the pulse 168 beats per minute, the blood pressure 95/61, the respiratory rate 24 breaths per minute and the oxygen saturation 96%. He was well appearing with a physical exam significant for injected limbic-sparing conjunctiva without discharge. His oropharynx was minimally erythematous without exudate or lesions. His mucous membranes were moist with mild cracking of his lips. He had no lymphadenopathy and no evidence of meningismus. His cardiac exam revealed tachycardia with no murmur auscultated. His pulses were strong with capillary refill less than 2 s. His pulmonary exam was normal. He did not have abdominal tenderness nor hepatosplenomegaly with normal bowel sounds. He had a diffuse rash most prominent on his extremities that appeared mildly erythematous with blanching macules and patches involving the trunk as well as palms and soles (Fig. 1a). There was no palmar erythema.

Fig. 1

a Diffuse rash appearing mildly erythematous with blanching macules and patches involving the trunk and extremities. b ECG: Sinus tachycardia with low voltages

Given his fever and tachycardia, he was given 400 mg of ibuprofen orally. An ambulatory saturation was performed by having him march in place while attached to a pulse oximeter. His heart rate increased to 180 beats per minute and oxygen saturation increased to 98%. He became lightheaded, which resolved with laying back down. An intravenous line was placed to obtain labs and provide 500 cc normal saline bolus. Electrocardiogram demonstrated sinus tachycardia with low voltages (Fig. 1b).

Laboratory results were revealing for the following: elevated white blood cell count of 16.8K/µL, hemoglobin of 12.4 g/dL, and platelets of 207K/µL with a differential with elevated absolute neutrophils of 14.45K/µL and depressed absolute lymphocytes of 1.18K/µL. Basic metabolic panel was significant for a sodium of 125 mmol/L, potassium of 3.4 mmol/L, chloride 87 mmol/L, bicarbonate of 20 mmol/L and normal BUN and creatinine. Liver function tests were normal. Phosphorus was low at 2.1 mmol/L. Acute phase reactants were significantly elevated with an erythrocyte sedimentation rate of 57 mm/h, a c-reactive protein of 280 mg/L, and a procalcitonin of 28 ng/mL (ref range 0–0.08 ng/mL). Specific laboratory tests per our institution-specific COVID-19 algorithm included a d-dimer of 2727 ng/mL, ferritin of 1089 µg/L, lactate dehydrogenase of 360 U/L, fibrinogen of 748 mg/dL, and an INR of 1.3. His creatinine kinase was low at 46 U/L and high-sensitivity troponin was elevated at 84 ng/L (ref range 0–14 ng/L). His rapid streptococcus test came back negative, EBV serologies were consistent with past infection, and the lactate was normal. His COVID PCR test resulted positive.

With fever reduction and fluid resuscitation, the heart rate decreased to 132. A venous blood gas was obtained that showed a pH of 7.45, PCO2 of 34 and PO2 of 50. Bedside ultrasound demonstrated severely diminished left ventricular systolic function with trace pericardial effusion (as shown in the animation Online Resource 1). NT-proBNP assay resulted at 9,477 pg/mL and the patient became further hypotensive to 75/44. He had diminished peripheral pulses with delayed capillary refill, and a gallop was appreciated upon auscultation. Dopamine was initiated at 5 µg/kg/min and titrated up to 10 µg/kg/min with adequate response. Given that the pediatric intensive care unit at our institution had been converted to adult COVID-19 patients, the patient was transferred to an outside institution. At the time of this writing, the patient continues to be critically ill with outcome yet to be determined.


This case illustrates the unique presentation of a COVID-19 patient with features of KD and myocarditis, presenting with stable vital signs and a normal ambulatory saturation. To date, there has been one published case of a pediatric COVID-19 patient with concurrent KD without cardiac dysfunction [2] and several case series describing myocarditis as a COVID-19 presentation in the adult population [3,4,5,6,7]. Myocarditis occurs frequently in KD with a prior study demonstrating up to 20% of patients with left ventricular systolic dysfunction [8]. Additionally, the findings of conjunctivitis and rash have been described as clinical features in the COVID-19 adult population [9], further complicating the interpretation of KD features. Following this experience, our institution has established a pediatric COVID-19 cardiac disease algorithm in the ED that includes initial cardiac biomarkers (high-sensitivity troponin and NT-proBNP) and ECG evaluation for those suspected or confirmed to have COVID-19 who are ill appearing or require admission. Patients presenting with KD features requiring admission now undergo two PCR COVID-19 tests 24 h apart prior to clearance. Further investigation of wide ranging clinical features of COVID-19 in the pediatric population remains urgent.


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Correspondence to Joanne S. Chiu.

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Supplementary video 1—Bedside ultrasound demonstrated severely diminished left ventricular systolic function (MP4 1711 kb)

Supplementary video 1—Bedside ultrasound demonstrated severely diminished left ventricular systolic function (MP4 1711 kb)

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Chiu, J.S., Lahoud-Rahme, M., Schaffer, D. et al. Kawasaki Disease Features and Myocarditis in a Patient with COVID-19. Pediatr Cardiol (2020). https://doi.org/10.1007/s00246-020-02393-0

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  • Kawasaki
  • COVID-19
  • Myocarditis