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Pediatric Cardiology

, Volume 39, Issue 8, pp 1535–1539 | Cite as

Does Prophylactic Ibuprofen After Surgical Atrial Septal Defect Repair Decrease the Rate of Post-Pericardiotomy Syndrome?

  • Edon J. Rabinowitz
  • David B. Meyer
  • Priya Kholwadwala
  • Nina Kohn
  • Adnan Bakar
Original Article

Abstract

Post-pericardiotomy syndrome (PPS) is an inflammatory process involving the pleura, pericardium, or both and occurs after cardiothoracic surgery. Surgical atrial septal defect (ASD) closure is associated with higher incidence of PPS post-operatively as compared to other operations. Reported incidence of PPS varies from 1 to 40%. NSAIDs are often used to treat PPS and in our center, some practitioners have prescribed ibuprofen prophylactically. This study sought to investigate the impact of prophylactic treatment with ibuprofen on the development and severity of PPS following surgical ASD closure, with particular attention to secundum-type ASDs. We retrospectively reviewed clinical and operative data of all surgical ASD repairs in our center from 1/2007 to 7/2017. ASDs were grouped by subtype. PPS was considered positive if the primary cardiologist diagnosed and documented clinical signs of PPS on post-operative outpatient follow-up. Records were reviewed to confirm documented diagnosis of PPS. A total of 245 cases were reviewed with 207 having sufficient data. Median age was 2 years (range 4 months–27 years), female 57%. Overall incidence of PPS was 10%. There was no difference in incidence of PPS in those prescribed ibuprofen as compared to those who were not. This was true for both the entire cohort and the subgroup analysis (P = 1.0). Four patients overall required pericardiocentesis, none of whom received prophylactic ibuprofen. Prophylactic ibuprofen prescription following surgical ASD repair did not reduce the rate of PPS in our cohort.

Keywords

Atrial septal defect Post-pericardiotomy syndrome Post-cardiac injury syndrome Ibuprofen Non-steroidal anti-inflammatory drugs 

Abbreviations

PPS

Post-pericardiotomy syndrome

ASD

Atrial septal defect

CHD

Congenital heart disease

NSAIDs

Non-steroidal anti-inflammatory drugs

SV

Sinus venosus

CS

Coronary sinus

Notes

Compliance with Ethical Standards

Conflict of interest

All authors declare that they have no conflicts of interest relevant to this article to disclose.

Research Involving Human and Animal Participants

This article does not contain any studies with human participants or animals performed by any of the authors.

Informed Consent

A waiver of informed consent was obtained from the Northwell Health institutional review board.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Division of Pediatric CardiologyCohen Children’s Medical Center of New York, Hofstra Northwell School of MedicineNew Hyde ParkUSA
  2. 2.Division of Cardiothoracic SurgeryCohen Children’s Medical Center of New York, Hofstra Northwell School of MedicineNew Hyde ParkUSA
  3. 3.Department of PediatricsCohen Children’s Medical Center of New York, Hofstra Northwell School of MedicineNew Hyde ParkUSA
  4. 4.Department of BiostatisticsFeinstein Institute for Medical Research, Hofstra Northwell School of MedicineManhassetUSA
  5. 5.Division of Pediatric Critical Care MedicineCohen Children’s Medical Center of New York, Hofstra Northwell School of MedicineNew Hyde ParkUSA

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