Fates Aligned: Origins and Mechanisms of Ventricular Conduction System and Ventricular Wall Development
The cardiac conduction system is a network of distinct cell types necessary for the coordinated contraction of the cardiac chambers. The distal portion, known as the ventricular conduction system, allows for the rapid transmission of impulses from the atrio-ventricular node to the ventricular myocardium and plays a central role in cardiac function as well as disease when perturbed. Notably, its patterning during embryogenesis is intimately linked to that of ventricular wall formation, including trabeculation and compaction. Here, we review our current understanding of the underlying mechanisms responsible for the development and maturation of these interdependent processes.
KeywordsConduction system Myocardial development Arrhythmia
This work was supported by the NIH Office of Director’s Pioneer Award LM012179-03, the American Heart Association Established Investigator Award 17EIA33410923, the Department of Pediatrics and Division of Pediatric Cardiology at Lucille Packard Children’s Hospital, the Stanford Cardiovascular Institute, the Stanford Division of Cardiovascular Medicine, Department of Medicine, the Institute for Stem Cell Biology and Regenerative Medicine, and an endowed faculty scholar award from the Stanford Child Health Research Institute/Lucile Packard Foundation for Children (S.M.W). This was also supported by the Training Grant (T32) entitled Research Training in Myocardial Biology at Stanford (NIH 2 T32 HL094274) (W.R.G.).
Compliance with Ethical Standards
Conflict of interest
W.R.G. declares that he has no conflict of interest. S.M.W. declares that he has no conflict of interest.
This article does not contain any studies with human participants or animals performed by any of the authors.
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