Age-Dependent Association Between Pre-transplant Blood Transfusion and Outcomes of Pediatric Heart Transplantation
- 141 Downloads
Avoidance of red blood cell (RBC) transfusions in patients awaiting heart transplantation (HTx) has been suggested to minimize the risk of allosensitization. Although recent studies have suggested that an immature immune system in younger HTx recipients may reduce risks associated with RBC transfusion, the role of age in moderating the influence of transfusion on HTx outcomes remains unclear. We used available data from a national transplant registry to explore whether the association between pre-transplant transfusions and outcomes of pediatric HTx varies by patient age. De-identified data were obtained from the United Network for Organ Sharing registry, including first-time recipients of isolated HTx performed at age 0–17 years in 1995–2015. The primary exposure was receiving blood transfusions within 2 weeks prior to HTx. Patient survival after HTx was evaluated using multivariable Cox proportional hazards, where age at transplant was interacted with exposure to pre-transplant transfusion. Age-specific hazard ratios (HRs) of pre-transplant transfusion were plotted across ages at transplant. There were 4883 patients meeting inclusion criteria, of whom 1258 died during follow-up (mean follow-up duration 6 ± 5 years). Patients receiving pre-transplant transfusions were distinguished by younger age, higher prevalence of prior cardiac surgery, greater likelihood of being in the intensive care unit, and greater use of left ventricular assist device bridge to transplant. In multivariable analysis, pre-transplant transfusions were associated with increased mortality hazard among infants < 1 year of age (HR = 1.46; 95% CI 1.23, 1.74; p < 0.001). For each additional year of age, the excess hazard associated with pre-transplant transfusions decreased by 3% (interaction HR = 0.97; 95% CI 0.98, 0.99; p = 0.003). By age 8, the association between pre-transplant transfusions and post-transplant mortality was no longer statistically significant (HR = 1.15; 95% CI 0.99, 1.32; p = 0.060). Pre-transplant transfusions were associated with increased mortality hazard only among younger children (age < 8 years) undergoing HTx. These data support the current practices of transfusion avoidance prior to HTx, particularly in younger patients.
KeywordsBlood transfusion Pediatric Heart transplantation Cardiac intensive care
CM assisted with study design and manuscript drafting and revision. DT assisted with statistical analysis and manuscript drafting. BRA provided initial study concept and assisted with manuscript revision. KKN provided initial study concept and critical revision of manuscript. ARY provided initial study concept and critical revision of manuscript. DHJ assisted with study design and manuscript drafting and revision. JDT assisted with study design and manuscript revision. All authors approved of the final version of this manuscript.
Compliance with Ethical Standards
Conflict of interest
Christopher McKee, Dmitry Tumin, B. Rita Alevriadou, Kathleen K. Nicol, Andrew R. Yates, Don Hayes Jr., Joseph D. Tobias declares that they have no conflict of interest.
This article does not contain any studies with human participants or animals performed by any of the authors. The study was deemed exempt from review by the Institutional Review Board at Nationwide Children’s Hospital.
- 2.Vanderlaan RD, Manlhiot C, Edwards LB, Conway J, McCrindle BW, Dipchand AI (2015) Risk factors for specific causes of death following pediatric heart transplant: an analysis of the registry of the International Society of Heart and Lung Transplantation. Pediatr Transplant 19(8):896–905CrossRefPubMedGoogle Scholar
- 7.United Network for Organ Sharing/Organ Procurement and Transplantation Network. Standard Transplant Analysis and Research Database. http://optn.transplant.hrsa.gov/data/about/OPTNDatabase.asp. Accessed 25 Sept 2015
- 15.Opelz G, Vanrenterghem Y, Kirste G, Gray DW, Horsburgh T, Lachance JG, Largiader F, Lange H, Vujaklija-Stipanovic K, Alvarez-Grande J, Schott W, Hoyer J, Schnuelle P, Descoeudres C, Ruder H, Wujciak T, Schwarz V (1997) Prospective evaluation of pretransplant blood transfusions in cadaver kidney recipients. Transplantation 63(7):964–967CrossRefPubMedGoogle Scholar
- 17.van de Watering LM, Hermans J, Houbiers JG, van den Broek PJ, Bouter H, Boer F, Harvey MS, Huysmans HA, Brand A (1998) Beneficial effects of leukocyte depletion of transfused blood on postoperative complications in patients undergoing cardiac surgery: a randomized clinical trial. Circulation 97(6):562–568CrossRefPubMedGoogle Scholar