Serum Concentrations of New Predictive Cardiovascular Disease Biomarkers in Mexican Women Exposed to Lead
The purpose of this study was to evaluate lead exposure and its relationship with serum levels of predictive CVD biomarkers [asymmetric dimethylarginine (ADMA), adipocyte fatty acid-binding protein (FABP4), adiponectin, and chemerin] in women living in San Luis Potosi, Mexico. A mean blood lead level (BLL) of 11.5 ± 9.00 μg/dL (mean ± standard deviation) was found after all blood samples were analyzed. Regarding serum predictive CVD biomarkers, mean serum level of 0.68 ± 0.38 μmol/L, 20.5 ± 16.5 ng/mL, 12.5 ± 3.30 μg/mL, and 255 ± 130 ng/mL were found for ADMA, FABP4, adiponectin, and chemerin, respectively. Simple significant associations (Pearson´s correlations) between BLL and ADMA (r = 0.17; p = 0.04) and FABP4 (r = 0.23; p = 0.03) were found. Furthermore, a multivariate linear regression model showed that BLL was a significant predictor of serum ADMA (β = 0.06; p = 0.001) and FABP4 (β = 1.75; p = 0.0004) concentrations after adjusting by confounders. For serum chemerin and adiponectin levels, no associations were found with BLL. In conclusion, high serum ADMA and FABP4 (predictive CVD biomarkers) levels were found in women exposed to lead. Consequently, this research can be used as a point of departure for the prevention of CVD events in populations living in sites environmentally impacted with lead.
This work was supported by CONACyT (Grant CONACyT- PDCPN2015-1558 and Fondo Sectorial SEMARNAT–CONACYT-249421). Special Thanks to Miss Laura Carmen Martinez for English language editing.
Compliance with Ethical Standards
Conflict of interest
The authors report no declaration of interest.
- Baum C, Johannsen SS, Zeller T et al (2016) ADMA and arginine derivatives in relation to non-invasive vascular function in the general population. Atherosclerosis 244:149–156. https://doi.org/10.1016/j.atherosclerosis.2015.10.101 CrossRefGoogle Scholar
- Böger RH, Maas R, Schulze F, Schwedhelm E (2009a) Asymmetric dimethylarginine (ADMA) as a prospective marker of cardiovascular disease and mortality—an update on patient populations with a wide range of cardiovascular risk. Pharmacol Res 60:481–487. https://doi.org/10.1016/j.phrs.2009.07.001 CrossRefGoogle Scholar
- Estrada-Sanchez D, Ericson B, Juarez-Perez CA et al (2017) Intelligence quotient loss in Mexican pottery artisan’s children. Rev Med Inst Mex Seguro Soc 55:292–299Google Scholar
- Hao Y, Ma X, Luo Y et al (2014) Serum adipocyte fatty acid binding protein levels are positively associated with subclinical atherosclerosis in Chinese pre- and postmenopausal women with normal glucose tolerance. J Clin Endocrinol Metab 99:4321–4327. https://doi.org/10.1210/jc.2014-1832 CrossRefGoogle Scholar
- Hsu C-P, Lin S-J, Chung M-Y, Lu T-M (2012) Asymmetric dimethylarginine predicts clinical outcomes in ischemic chronic heart failure. Atherosclerosis 225:504–510. https://doi.org/10.1016/j.atherosclerosis.2012.09.040 CrossRefGoogle Scholar
- Leong T, Zylberstein D, Graham I et al (2008) Asymmetric dimethylarginine independently predicts fatal and nonfatal myocardial infarction and stroke in women: 24-Year follow-up of the population study of women in Gothenburg. Arterioscler Thromb Vasc Biol 28:961–967. https://doi.org/10.1161/ATVBAHA.107.156596 CrossRefGoogle Scholar
- NHANES IV (2009) Fourth national report on human exposure to environmental chemicals. Department of Health and Human Services Centers for Disease Control and Prevention, AtlantaGoogle Scholar
- Ochoa-Martinez AC, Ruiz-Vera T, Almendarez-Reyna CI et al (2017a) Influence on serum asymmetric dimethylarginine (ADMA) concentrations of human paraoxonase 1 polymorphism (Q192R) and exposure to polycyclic aromatic hydrocarbons (PAHs) in Mexican women, a gene-environment interaction. Chemosphere 186:770–779. https://doi.org/10.1016/j.chemosphere.2017.08.055 CrossRefGoogle Scholar
- Ochoa-Martinez AC, Ruiz-Vera T, Pruneda-Alvarez LG et al (2017c) Serum adipocyte-fatty acid binding protein (FABP4) levels in women from Mexico exposed to polycyclic aromatic hydrocarbons (PAHs). Environ Sci Pollut Res Int 24:1862–1870. https://doi.org/10.1007/s11356-016-7971-8 CrossRefGoogle Scholar
- Pruneda-Alvarez LG, Perez-Vazquez FJ, Ruiz-Vera T et al (2016a) Urinary 1-hydroxypyrene concentration as an exposure biomarker to polycyclic aromatic hydrocarbons (PAHs) in Mexican women from different hot spot scenarios and health risk assessment. Environ Sci Pollut Res Int 23:6816–6825. https://doi.org/10.1007/s11356-015-5918-0 CrossRefGoogle Scholar
- Pruneda-Alvarez LG, Ruíz-Vera T, Ochoa-Martínez AC et al (2016b) Plasma asymmetric dimethylarginine (ADMA) levels in Mexican women exposed to polycyclic aromatic hydrocarbons (PAHs): a preliminary study. Sci Total Environ 572:1195–1202. https://doi.org/10.1016/j.scitotenv.2016.08.037 CrossRefGoogle Scholar
- Ruiz-Vera T, Pruneda-Alvarez LG, Perez-Vazquez FJ et al (2015b) Using urinary 1-hydroxypyrene concentrations to evaluate polycyclic aromatic hydrocarbon exposure in women using biomass combustion as main energy source. Drug Chem Toxicol 38:349–354. https://doi.org/10.3109/01480545.2014.968932 CrossRefGoogle Scholar
- Schnabel R, Blankenberg S, Lubos E et al (2005) Asymmetric dimethylarginine and the risk of cardiovascular events and death in patients with coronary artery disease: results from the AtheroGene Study. Circ Res 97:e53–e59. https://doi.org/10.1161/01.RES.0000181286.44222.61 CrossRefGoogle Scholar
- von Eynatten M, Breitling LP, Roos M et al (2012) Circulating adipocyte fatty acid-binding protein levels and cardiovascular morbidity and mortality in patients with coronary heart disease: a 10-year prospective study. Arterioscler Thromb Vasc Biol 32:2327–2335. https://doi.org/10.1161/ATVBAHA.112.248609 CrossRefGoogle Scholar
- Yu H-P, Jen H-L, Yin W-H, Wei J (2017) Circulating adiponectin levels following treatment can predict late clinical outcomes in chronic heart failure. Acta Cardiol Sin 33:139–149Google Scholar