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Polymorphisms of the VDR gene in patients with nephrolithiasis in a Han Chinese population

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Abstract

An association study between VDR gene polymorphisms and nephrolithiasis was conducted in different populations, but it is not yet known whether the association exists in the Han Chinese population. Here, we genotyped three SNPs (rs731236, rs7975232 and rs10735810) in the promoter region of the VDR gene by iMLDR genotyping assays in a large case–control cohort. The results demonstrated that there was no association found between the three SNPs (rs731236, rs7975232 and rs10735810) in the VDR gene and nephrolithiasis, whether in allele or genotype distribution. However, SNP rs10735810 was correlated with the level of serum calcium in control groups, but not in patient groups. In conclusion, considering the large sample size, we believe that the SNP rs10735810 allele A in the VDR gene promoter region may influence the level of serum calcium, but not influence the formation of nephrolithiasis in a Han Chinese population.

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Funding

Current work was supported partly by the National Natural Science Foundation of China (81470989 and 81600588), and partly by the clinical research project key projects of Second Affiliated Hospital, Third Military Medical University (2015YLC06).

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Authors and Affiliations

  1. Department of Urology, Second Affiliated Hospital, Third Military Medical University, Chongqing, People’s Republic of China

    Zhenxing Yang, Qingqing Wang & Longkun Li

  2. Department of Pediatrics, Ostrow School of Dentistry, School of Medicine, University of Southern California, Los Angeles, CA, USA

    Jiang F. Zhong

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  1. Zhenxing Yang
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  2. Qingqing Wang
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  3. Jiang F. Zhong
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  4. Longkun Li
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Correspondence to Longkun Li.

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The authors declare no competing financial interest.

Ethical approval

This study was conducted with the approval of the ethics committee of Third Military Medical University.

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Yang, Z., Wang, Q., Zhong, J.F. et al. Polymorphisms of the VDR gene in patients with nephrolithiasis in a Han Chinese population. Urolithiasis 47, 149–154 (2019). https://doi.org/10.1007/s00240-018-1053-y

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  • DOI: https://doi.org/10.1007/s00240-018-1053-y

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