Skip to main content

Advertisement

SpringerLink
Log in

Usefulness of preoperative three-dimensional volumetric analysis of carotid body tumors

  • Diagnostic Neuroradiology
  • Published:
Neuroradiology Aims and scope Submit manuscript

Abstract

Purpose

The Shamblin classification is the commonest method to predict complications and outcomes during carotid body tumor (CBT) resection. The aim of this study is to describe the utility of the three-dimensional volumetric reconstruction (3DVR) analysis of the CBT and its relationship with postoperative outcomes.

Methods

Preoperative computed tomography angiography (CTA) was obtained to perform 3DVR of the CBT. Imaging data were analyzed and correlated with surgical outcomes: estimated blood loss (EBL), surgical time (ST), and hospital length of stay (HLOS). The Pearson test was used to determine the correlation between volume and postoperative outcomes.

Results

Fifty-seven patients were studied, 13 had Shamblin type I tumors with a mean 3DVR of 7.69 cm3 (standard deviation [SD 8.27]), 21 were type II with a mean 3DVR of 15.57 cm3 (SD 8.40), and 23 were type III with a mean 3DVR of 30.58 cm3 (SD 20.16). EBL mean was 559 milliliters (mL) (standard error [SE] 80.44), the mean ST of resection was 202 min (SD 67), and the mean HLOS was 5.8 days (SD 3.23). The Pearson test showed a correlation of r = 0.69 (p < 0.0001) between 3DVR and EBL, a r = 0.4 (p = 0.05) was obtained between 3DVR and ST, and finally, a r = 0.3 (p = 0.05) between 3DVR and HLOS was obtained.

Conclusion

The preoperative 3DVR determination of CBTs allows to analyze possible predictors of surgical outcomes. We found a positive correlation between the 3DVR volume and EBL. Further research is necessary to validate this method in the evaluation of these rare neoplasms.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Hinojosa CA, Ortiz-Lopez LJ, Anaya-Ayala JE, Orozco-Sevilla V, Nunez-Salgado AE (2015) Comparison of retrocarotid and caudocranial dissection techniques for the surgical treatment of carotid body tumors. J Vasc Surg 62:958–964

    Article  Google Scholar 

  2. Wang ZY, Bisgard GE (2002) Chronic hypoxia-induced morphological and neurochemical changes in the carotid body. Microsc Res Tech 59:168–177

    Article  CAS  Google Scholar 

  3. Rodriguez-Cuevas S, Lopez-Garza J, Labastida-Almendaro S (1998) Carotid body tumors in inhabitants of altitudes higher than 2000 meters above sea level. Head Neck 20:374–378

    Article  CAS  Google Scholar 

  4. Davila VJ, Chang JM, Stone WM, Fowl RJ, Bower TC, Hinni ML, Money SR (2016) Current surgical management of carotid body tumors. J Vasc Surg 64:1703–1710

    Article  Google Scholar 

  5. Jech M, Alvarado-Cabrero I, Albores-Saavedra J, Dahia PL, Tischler AS (2006) Genetic analysis of high altitude paragangliomas. Endocr Pathol 17:201–202

    Article  Google Scholar 

  6. Hinojosa CA, Anaya-Ayala JE, Laparra-Escareno H, Torres-Machorro A, Lizola R, Gamboa-Dominguez A (2017) Concomitant surgical treatment of symptomatic carotid artery disease with a coexisting Shamblin I carotid body tumor. Vasc Endovasc Surg 51:103–107

    Article  Google Scholar 

  7. Schulz SA, Wohler A, Beutner D, Angelov DN (2016) Microsurgical anatomy of the human carotid body (glomus caroticum): features of its detailed topography, syntopy and morphology. Ann Anat 204:106–113

    Article  Google Scholar 

  8. Hinojosa CA, Anaya-Ayala JE, Olivares-Cruz S, Laparra-Escareno H, Trolle-Silva A, Angeles-Angeles H (2018) Malignant Shamblin III carotid body tumors resected with use of the retrocarotid dissection technique in 2 patients. Tex Heart Inst J 45:92–95

    Article  Google Scholar 

  9. Metheetrairut C, Chotikavanich C, Keskool P, Suphaphongs N (2016) Carotid body tumor: a 25-year experience. Eur Arch Otorhinolaryngol 273:2171–2179

    Article  Google Scholar 

  10. Fokkema M, de Borst GJ, Nolan BW, Indes J, Buck DB, Lo RC, Moll FL, Schermerhorn ML (2014) Clinical relevance of cranial nerve injury following carotid endarterectomy. Eur J Vasc Endovasc Surg 47:2–7

    Article  CAS  Google Scholar 

  11. Shamblin WR, ReMine WH, Sheps SG, Harrison EG Jr (1971) Carotid body tumor (chemodectoma). Clinicopathologic analysis of ninety cases. Am J Surg 122:732–739

    Article  CAS  Google Scholar 

  12. Luna-Ortiz K, Rascon-Ortiz M, Villavicencio-Valencia V, Herrera-Gomez A (2006) Does Shamblin’s classification predict postoperative morbidity in carotid body tumors? A proposal to modify Shamblin’s classification. Eur Arch Otorhinolaryngol 263:171–175

    Article  Google Scholar 

  13. Michalowska I, Lewczuk A, Cwikla J, Prejbisz A, Swoboda-Rydz U, Furmanek M et al (2016) Evaluation of head and neck paragangliomas by computed tomography in patients with pheochromocytoma-paraganglioma syndromes. Pol J Radiol 81:510–518

    Article  Google Scholar 

  14. Jin ZQ, He W, Wu DF, Lin MY, Jiang HT (2016) Color doppler ultrasound in diagnosis and assessment of carotid body tumors: comparison with computed tomography angiography. Ultrasound Med Biol 42:2106–2113

    Article  Google Scholar 

  15. Law Y, Chan YC, Cheng SW (2017) Surgical management of carotid body tumor. Is Shamblin classification sufficient to predict surgical outcome? Vascular 25:184–189

    Article  CAS  Google Scholar 

  16. Straughan DM, Neychev VK, Sadowski SM, Ellis RJ, Thomas F, Patronas NJ, Pacak K, Kebebew E, Nilubol N (2015) Preoperative imaging features are associated with surgical complications following carotid body tumor resection. World J Surg 39:2084–2089

    Article  Google Scholar 

  17. Kim GY, Lawrence PF, Moridzadeh RS, Zimmerman K, Munoz A, Luna-Ortiz K, Oderich GS, de Francisco J, Ospina J, Huertas S, de Souza LR, Bower TC, Farley S, Gelabert HA, Kret MR, Harris EJ Jr, de Caridi G, Spinelli F, Smeds MR, Liapis CD, Kakisis J, Papapetrou AP, Debus ES, Behrendt CA, Kleinspehn E, Horton JD, Mussa FF, Cheng SWK, Morasch MD, Rasheed K, Bennett ME, Bismuth J, Lumsden AB, Abularrage CJ, Farber A (2017) New predictors of complications in carotid body tumor resection. J Vasc Surg 65:1673–1679

    Article  Google Scholar 

  18. Lambin P, Rios-Velazquez E, Leijenaar R, Carvalho S, van Stiphout RG, Granton P et al (2012) Radiomics: extracting more information from medical images using advanced feature analysis. Eur J Cancer 48:441–446

    Article  Google Scholar 

  19. Heesterman BL, de Pont LMH, Verbist BM, van der Mey AGL, Corssmit EPM, Hes FJ et al (2017) Age and tumor volume predict growth of carotid and vagal body paragangliomas. J Neurol Surg B Skull Base 78:497–505

    Article  Google Scholar 

  20. Heesterman BL, Verbist BM, van der Mey AG, Bayley JP, Corssmit EP, Hes FJ, Jansen JC (2016) Measurement of head and neck paragangliomas: is volumetric analysis worth the effort? A method comparison study. Clin Otolaryngol 41:571–578

    Article  CAS  Google Scholar 

  21. Weathley JM, Rosenfield NS, Heller G, Feldstein D, Michael P, Laquaglia MP (1994) Validation of a technique of computer-aided tumor volume determination. J Surg Res 59(6):621–626

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Surgery, Section of Vascular Surgery and Endovascular Therapy, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga 15, Colonia Sección XVI, 14080, Mexico City, Mexico

    Rodrigo Lozano-Corona, Javier E. Anaya-Ayala, Sabsil López-Rocha, Melisa A. Rivas-Rojas, Adriana Torres-Machorro, Hugo Laparra-Escareno & Carlos A. Hinojosa

  2. Department of Radiology, Instituto Nacional de Ciencias Médicas y Nutrición “Salvador Zubirán”, 14080, Mexico City, Mexico

    Ricardo Martínez-Martínez

Authors
  1. Rodrigo Lozano-Corona
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Javier E. Anaya-Ayala
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Ricardo Martínez-Martínez
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Sabsil López-Rocha
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Melisa A. Rivas-Rojas
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Adriana Torres-Machorro
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Hugo Laparra-Escareno
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Carlos A. Hinojosa
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Carlos A. Hinojosa.

Ethics declarations

Funding

No funding was received for this study.

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in the studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. For this type of study formal consent is not required.

Informed consent

For this type of retrospective study formal consent is not required; all study data was anonymized and is not traceable to the patient.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Lozano-Corona, R., Anaya-Ayala, J.E., Martínez-Martínez, R. et al. Usefulness of preoperative three-dimensional volumetric analysis of carotid body tumors. Neuroradiology 60, 1281–1286 (2018). https://doi.org/10.1007/s00234-018-2095-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00234-018-2095-0

Keywords

Search

Navigation