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Diffusion parameters of the core of cingulum are associated with age-related ventricular enlargement: a diffusion tensor tractography study

  • Diagnostic Neuroradiology
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Abstract

Purpose

To evaluate the influence of the size of lateral ventricles on diffusion parameters of the normal cingulate bundle.

Methods

Eighty normal subjects (17–55 years) underwent MRI at 3 T including diffusion tensor imaging. Superior (SC) and inferior (IC) cingulum were analyzed separately. Mean diffusivity (MD0.30) and fractional anisotropy (FA0.30) were measured by tractography at FA threshold 0.30; further diffusion parameters were analyzed by tractography-based core analysis in volumes of 3.0 cm3/1.5 cm3. The diffusion parameters were correlated with corresponding cross-sectional coronal areas of lateral ventricles. The analysis was performed also separately for young (17–34) and middle-aged (35–55) subjects.

Results

FA0.30 values did not correlate with ventricular size, but there was a weak negative correlation (r = − 0.225) between MD0.30 of SC and ventricular size. In all controls and in the older age group, ventricular size correlated positively with core FA of SC (r = 0.262/r = 0.391) and negatively with mean diffusivity (r = − 0.324/r = − 0.303) and radial diffusivity (λ2: r = − 0.238/r = − 0.277; λ3: r = − 0.353/r = − 0.424) of the core of SC. In the younger age group, only the mean diffusivity of SC correlated with ventricular size (r = − 0.273). Ventricular size was not associated with axial diffusivity. The core parameters of IC did not correlate with ventricular size.

Conclusion

Radial diffusivity of the core of cingulum decreases in age-dependent ventricular enlargement, which can be related to tissue compaction with stretching of axons and diminution of extracellular spaces. The phenomenon, which is reverse to the assumed effect of age-related myelin loss, can influence on DTI parameters in middle-aged subjects.

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Authors and Affiliations

  1. Terveystalo Pulssi Medical Centre, 20100, Turku, Finland

    Timo J. I. Kurki

  2. Department of Radiology, University of Turku, 20520, Turku, Finland

    Timo J. I. Kurki

  3. Department of Neurology, University of Turku, 20014, Turku, Finland

    Lauri A. A. Heiskanen

Authors
  1. Timo J. I. Kurki
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  2. Lauri A. A. Heiskanen
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Correspondence to Timo J. I. Kurki.

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The authors declare that they have no conflict of interest.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Kurki, T.J.I., Heiskanen, L.A.A. Diffusion parameters of the core of cingulum are associated with age-related ventricular enlargement: a diffusion tensor tractography study. Neuroradiology 60, 1013–1018 (2018). https://doi.org/10.1007/s00234-018-2068-3

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  • DOI: https://doi.org/10.1007/s00234-018-2068-3

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