, Volume 60, Issue 5, pp 535–544 | Cite as

Risk factor analysis of recanalization and retreatment for patients with endovascular treatment of internal carotid artery bifurcation aneurysms

  • Seung Pil Ban
  • Gyojun Hwang
  • Chang Hyeun Kim
  • Hyoung Soo Byoun
  • Si Un Lee
  • Tackeun Kim
  • Jae Seung Bang
  • Chang Wan Oh
  • O-Ki Kwon
Interventional Neuroradiology



Only a few reports of internal carotid artery (ICA) bifurcation aneurysms using the endovascular technique have been published in the current literature. The purpose of this study was to assess how multiple risk factors including angioarchitectural features of ICA bifurcation characteristics may have influenced aneurysmal rupture, recanalization, and retreatment.


Fifty-one patients with 52 ICA bifurcation aneurysms treated with endovascular coiling between July 2003 and July 2015 were retrospectively analyzed. The patients’ clinical records, endovascular reports, and clinical and angiographic outcomes were reviewed. We also evaluated risk factors for recanalization and retreatment, including the angioarchitectural anatomy.


The clinical outcomes were observed to be satisfactory in 49 patients (96.0%) and unfavorable in 2 patients (4.0%). The risk factor for aneurysmal rupture was young age (P = 0.024). Symptomatic complications due to thromboembolism occurred in 1.9% of cases; no patients suffered a fatal complication. Eleven of 52 ICA bifurcation aneurysms (21.2%) were recanalized within an average of 54.3 ± 33.5 months of follow-up. Among the aneurysms, 4 (7.7%) underwent recoiling. Multivariate analysis showed that ruptured aneurysms (P = 0.006) and a lower packing density (P = 0.048) were risk factors for recanalization. A lower packing density was the only risk factor for retreatment (P = 0.019).


Endovascular treatment of ICA bifurcation aneurysms is considered safe and acceptable. This study showed that the ICA bifurcation aneurysms ruptured more frequently at a younger age. A higher packing density has been shown to reduce major recanalization and retreatment.


Coil embolization Internal carotid artery bifurcation Recanalization Intracranial aneurysm 



Anterior cerebral artery


Computational fluid dynamics


Digital subtraction angiography


High on-treatment platelet reactivity


Internal carotid artery


Modified Rankin Scale


P2Y12 reaction units


Stent-assisted coiling


Compliance with ethical standards


No funding was received for this study.

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

For this type of study formal consent is not required.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Seung Pil Ban
    • 1
  • Gyojun Hwang
    • 2
  • Chang Hyeun Kim
    • 3
  • Hyoung Soo Byoun
    • 1
  • Si Un Lee
    • 1
  • Tackeun Kim
    • 1
  • Jae Seung Bang
    • 1
  • Chang Wan Oh
    • 1
  • O-Ki Kwon
    • 1
  1. 1.Department of NeurosurgerySeoul National University Bundang HospitalSeongnamSouth Korea
  2. 2.Department of NeurosurgeryHallym University Hangang Sacred Heart HospitalSeoulSouth Korea
  3. 3.Department of NeurosurgeryPusan National University Yangsan HospitalYangsanSouth Korea

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