, Volume 59, Issue 7, pp 709–714 | Cite as

Abnormal baseline brain activity in Alzheimer’s disease patients with depression: a resting-state functional magnetic resonance imaging study

  • Xiaozheng Liu
  • Zhongwei Guo
  • Yanping Ding
  • Jiapeng Li
  • Gang Wang
  • Hongtao Hou
  • Xingli Chen
  • Enyan Yu
Functional Neuroradiology



As one of the most common mental disorders and the most important precursor of suicide in Alzheimer’s disease (AD), depression is associated with a decline in both well-being and daily functioning. At present, the diagnosis of AD patients with depression (D-AD) is largely dependent on clinical signs and symptoms, and the precise neural correlate underlying D-AD is still not fully understood.


The current study sought to investigate low-frequency oscillations at the voxel level in D-AD patients based on the amplitude of low-frequency fluctuations (ALFF) measured using resting-state functional magnetic resonance imaging. We examined 22 D-AD patients and 21 non-depressed AD (nD-AD) patients.


The results revealed that D-AD patients exhibited increased ALFF values in the left caudate and thalamus and decreased ALFF values in the left middle temporal pole compared with nD-AD patients.


These findings may provide further insight into the underlying neuropathophysiology of AD with depression.


Alzheimer’s disease Depression Functional magnetic resonance imaging Amplitude of low-frequency fluctuations 


Compliance with ethical standards


This study was funded by the National Health and Family Planning Commission scientific research funds-Zhejiang Medical Major Science and Technology Plan (WKJ-ZJ-1503), the West China Psychiatric Association (Wcpafund-201508), the Key Project of the Department of Science and Technology of Zhejiang Province (2013T301-1) to EY, the General Project of the Department of Science and Technology of Zhejiang Province (2017KY109) and the Doctoral Scientific Research Foundation of the Second Affiliated Hospital, Wenzhou Medical University to XZL.

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of Tongde Hospital of Zhejiang Province Research Committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2017

Authors and Affiliations

  • Xiaozheng Liu
    • 1
  • Zhongwei Guo
    • 2
  • Yanping Ding
    • 3
  • Jiapeng Li
    • 2
  • Gang Wang
    • 2
  • Hongtao Hou
    • 2
  • Xingli Chen
    • 2
  • Enyan Yu
    • 4
  1. 1.China-USA Neuroimaging Research Institute, Department of Radiology of the Second Affiliated Hospital and Yuying Children’s HospitalWenzhou Medical UniversityWenzhouChina
  2. 2.Tongde Hospital of Zhejiang ProvinceHangzhouChina
  3. 3.Hangzhou Sanatorium of People’s Liberation ArmyHangzhouChina
  4. 4.People’s Hospital of Zhejiang ProvinceHangzhouChina

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