Neuroradiology

, Volume 59, Issue 7, pp 665–675 | Cite as

Differential diagnosis of oligodendroglial and astrocytic tumors using imaging results: the added value of perfusion MR imaging

  • Hyun Jung Yoon
  • Kook Jin Ahn
  • Song Lee
  • Jin Hee Jang
  • Hyun Seok Choi
  • So Lyung Jung
  • Bum Soo Kim
  • Shin Soo Jeun
  • Yong Kil Hong
Diagnostic Neuroradiology

Abstract

Purpose

The purposes of the present study are to assess whether different characteristics of oligodendrogliomas and astrocytic tumors are visible on MR imaging and to determine the added value of perfusion imaging in conventional MR imaging when differentiating oligodendrogliomas from astrocytic tumors.

Methods

We retrospectively studied 22 oligodendroglioma and 54 astrocytic tumor patients, including glioblastoma multiforme (GBM). The morphological tumor characteristics were evaluated using MR imaging. The rCBV, K trans, and V e values were recorded. All imaging and clinical values were compared. The ability to discriminate between the two entities was evaluated using receiver operating characteristic curve analyses. Separate comparison analysis between oligodendroglioma and astrocytic tumors excluding GBM was also performed.

Results

The presence of calcification, higher cortex involvement ratio, and lower V e value were more representative of oligodendrogliomas than astrocytic tumors (P = <0.001, 0.038, and <0.001, respectively). The area under the curve (AUC) value of a combination of calcification and cortex involvement ratio was 0.796. The combination of all three parameters, including V e, further increased the diagnostic performance (AUC = 0.881). Comparison test of the two AUC areas revealed significant difference (P = 0.0474). The presence of calcification and higher cortex involvement ratio were the only findings suggestive of oligodendrogliomas than astrocytic tumors with exclusion of GBMs (P = 0.014 and <0.001, respectively).

Conclusion

Cortex involvement ratio and the presence of calcification with V e values were diagnostically accurate in identifying oligodendrogliomas. The V e value calculated from dynamic contrast-enhanced MR imaging could be a supportive tool for differentiating between oligodendrogliomas and astrocytic tumors including GBMs.

Keywords

Oligodendroglioma Magnetic resonance imaging Dynamic contrast-enhanced MR imaging Ktrans Ve 

Notes

Compliance with ethical standards

Funding

No funding was received for this study.

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional review board of Seoul St. Mary’s and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. For this type of study, formal consent is not required.

Informed consent

Statement of informed consent was not applicable since the manuscript does not contain any patient data.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2017

Authors and Affiliations

  • Hyun Jung Yoon
    • 1
    • 2
  • Kook Jin Ahn
    • 2
  • Song Lee
    • 2
  • Jin Hee Jang
    • 2
  • Hyun Seok Choi
    • 2
  • So Lyung Jung
    • 2
  • Bum Soo Kim
    • 2
  • Shin Soo Jeun
    • 3
  • Yong Kil Hong
    • 3
  1. 1.Department of Radiology and Center for Imaging ScienceSamsung Medical Center, Sungkyunkwan University School of MedicineSeoulRepublic of Korea
  2. 2.Department of Radiology, College of MedicineSeoul St. Mary’s Hospital, The Catholic University of KoreaSeoulRepublic of Korea
  3. 3.Department of Neurosurgery, College of MedicineSeoul St. Mary’s Hospital, The Catholic University of KoreaSeoulRepublic of Korea

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