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Neuroradiology

, Volume 59, Issue 7, pp 699–708 | Cite as

Schizophrenia symptomatic associations with diffusion tensor imaging measured fractional anisotropy of brain: a meta-analysis

Functional Neuroradiology

Abstract

Purpose

Several studies have examined the relationships between diffusion tensor imaging (DTI)-measured fractional anisotropy (FA) and the symptoms of schizophrenia, but results vary across the studies. The aim of this study was to carry out a meta-analysis of correlation coefficients reported by relevant studies to evaluate the correlative relationships between FA of various parts of the brain and schizophrenia symptomatic assessments.

Methods

Literature was searched in several electronic databases, and study selection was based on précised eligibility criteria. Correlation coefficients between FA of a part of the brain and schizophrenia symptom were first converted into Fisher’s z-scores for meta-analyses, and then overall effect sizes were back transformed to correlation coefficients.

Results

Thirty-three studies (1121 schizophrenia patients; age 32.66 years [95% confidence interval (CI) 30.19, 35.13]; 65.95 % [57.63, 74.28] males) were included in this meta-analysis. Age was inversely associated with brain FA (z-scores [95% CI] −0.23 [−0.14, −0.32]; p ˂ 0.00001). Brain FA of various areas was inversely associated with negative symptoms of schizophrenia (z-score −0.30 [−0.23, −0.36]; p ˂ 0.00001) but was positively associated with positive symptoms of schizophrenia (z-score 0.16 [0.04, 0.27]; p = 0.007) and general psychopathology of schizophrenia (z-score 0.26 [0.15, 0.37]; p = 0.00001).

Conclusion

Although, DTI-measured brain FA is found to be inversely associated with negative symptoms and positively associated with positive symptoms and general psychopathology of schizophrenia, the effect sizes of these correlations are low and may not be clinically significant. Moreover, brain FA was also negatively associated with age of patients.

Keywords

Diffusion tensor imaging Fractional anisotropy Schizophrenia Psychosis Correlation 

Notes

Compliance with ethical standards

Funding

No funding was received for this study.

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors.

Informed consent

Informed consent was not required from the individual participants included in this study.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2017

Authors and Affiliations

  • Xu Yang
    • 1
    • 2
  • Ding Cao
    • 3
  • Xiumei Liang
    • 2
  • Jiannong Zhao
    • 1
  1. 1.Department of Medical Imaging, the Second Affiliated HospitalChongqing Medical UniversityChongqingChina
  2. 2.Department of Medical Imagingthe Fifth People’s Hospital of ChongqingChongqingChina
  3. 3.Department of Hepatobiliary Surgery, the Second Affiliated HospitalChongqing Medical UniversityChongqingChina

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