# Table 3 Pharmacokinetic model parameters for (S)-(nor)ketamine. Population parameters for (S)-ketamine were estimated by Fanta et al. [27]. Population parameters for *V*_{d} and CL were scaled allometrically: θ*(weight/70)^{exponent}, where the scaling exponent is 1 for *V*_{d} and 0.75 for CL. Shrinkage (%) of estimated IIV parameters is reported in brackets

Estimate | RSE% | |
---|---|---|

(S)-ketamine | ||

Population parameters (θ)
| ||

V_{d}
| 133 | - |

CL | 95.2 | - |

V_{p1}
| 187 | - |

Q_{1}
| 23.2 | - |

V_{p2}
| 98.8 | - |

Q_{2}
| 157 | - |

Inter-individual variability (ω^{2})
| ||

V_{d}
| 0.084 [7.1] | 28.4 |

CL | 0.026 [13.2] | 21.9 |

Covariance | 0.023 | 37.8 |

Residual variability (σ^{2})
| ||

Proportional error | 0.056 | 10.3 |

(S)-norketamine | ||

Population parameters (θ)
| ||

V_{d}
| 98.6 | 3.77 |

CL | 57.7 | 5.7 |

V_{p1}
| 160 | 17.6 |

Q_{1}
| 42.8 | 7.51 |

Inter-individual variability (ω^{2})
| ||

V_{d}
| 0.040 [22.9] | 29 |

CL | 0.103 [2.8] | 22 |

Covariance | 0.044 | 30.3 |

Residual variability (σ^{2})
| ||

Proportional error | 0.020 | 14.2 |