Fig. 5 | European Journal of Clinical Pharmacology

Fig. 5

From: Predictive performance of parent-metabolite population pharmacokinetic models of (S)-ketamine in healthy volunteers

Fig. 5

Prediction corrected visual predictive check (pcVPC) of the redeveloped a (S)-ketamine and b (S)-norketamine model predicting data of CHDR1311 and CHDR1016. The thick and thin black lines represent the median and 80% intervals of observed data. The pink and purple rectangles represent the 95% confidence intervals around the median and 80% prediction intervals of the predicted data. Observed concentrations were corrected for differences in dosing by multiplication with the ratio between the population predicted and the median population predicted value per bin and are shown as open dots

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