Fig. 4 | European Journal of Clinical Pharmacology

Fig. 4

From: Predictive performance of parent-metabolite population pharmacokinetic models of (S)-ketamine in healthy volunteers

Fig. 4

Confidence interval visual predictive checks (ciVPC) of (S)-norketamine model predictions of CHDR1311 data. ME = mean prediction error, RMSE = root mean squared prediction error (reported as their mean values with 95% CI in μg/L). a Jonkman et al. b Fanta et al. c Sigtermans et al. d Noppers et al. e Dahan et al. [18, 26, 27, 30, 31]. The thick and thin black lines represent the median and 80% intervals of observed data. The pink and purple rectangles represent the 95% confidence intervals around the median and 80% prediction intervals of the predicted data. The open dots show the observed concentrations

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