Fig. 1 | European Journal of Clinical Pharmacology

Fig. 1

From: Predictive performance of parent-metabolite population pharmacokinetic models of (S)-ketamine in healthy volunteers

Fig. 1

Schematic representation of (S)-(nor)ketamine literature PK model structures and the final redeveloped model structure. Kc and Nc depict the central (S)-ketamine and (S)-norketamine compartments; Kp1, Kp2, Np1, and Np2 are the first and second (S)-(nor)ketamine peripheral compartments; T represents the number of transit compartments. a Sigtermans et al., Noppers et al., and Jonkman et al. b Fanta et al. c Dahan et al. d Modified model structure of Fanta et al. based on CHDR1311 and CHDR1016 [18, 26, 27, 30, 31]

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