Abstract
Purpose
Potentially inappropriate medications (PIMs) have been associated with a greater risk of adverse drug events and hospitalizations. To reduce PIMs use, a family health team (FHT) implemented a knowledge translation (KT) strategy that included a pharmacist-physician intervention model based on alerts from a computerized alert system (CAS).
Methods
Our pragmatic, single-site, pilot study was conducted in an FHT clinic in Quebec, Canada. We included community-dwelling older adults (≥ 65 years), with at least 1 alert for selected PIMs and a medical appointment during the study period. PIMs were selected from the Beers and STOPP criteria. The primary outcome was PIMs cessation, decreased dose, or replacement. The secondary outcome was the clinical relevance of the alerts as assessed by the pharmacists.
Results
During the 134 days of the study, the CAS screened 369 individuals leading to the identification of 65 (18%) patients with at least 1 new alert. For those 65 patients, the mean age was 77 years, men accounted for 29% of the group and 55% were prescribed 10 or more drugs. One or more clinically relevant alerts were generated for 27 of 65 included patients for an overall clinical relevance of the alerts of 42%. Of the 27 patients with at least 1 relevant alert, 17 (63%) had at least 1 medication change as suggested by the pharmacist.
Conclusion
An interdisciplinary pharmacist-physician intervention model, based on alerts generated by a CAS, reduced the use of PIMs in community-dwelling older adults followed by an FHT.
Similar content being viewed by others
References
Lehnert T, Heider D, Leicht H, Heinrich S, Corrieri S, Luppa M, Riedel-Heller S, König HH (2011) Review: health care utilization and costs of elderly persons with multiple chronic conditions. Med Care Res Rev 68:387–420. https://doi.org/10.1177/1077558711399580
Beijer HJ, de Blaey CJ (2002) Hospitalisations caused by adverse drug reactions (ADR): a meta-analysis of observational studies. Pharm World Sci 24:46–54
Bressler R, Bahl JJ (2003) Principles of drug therapy for the elderly patient. Mayo Clin Proc 78:1564–1577. https://doi.org/10.4065/78.12.1564
Davies EC, Green CF, Taylor S, Williamson PR, Mottram DR, Pirmohamed M (2009) Adverse drug reactions in hospital in-patients: a prospective analysis of 3695 patient-episodes. PLoS One 4:e4439. https://doi.org/10.1371/journal.pone.0004439
Merle L, Laroche ML, Dantoine T, Charmes JP (2005) Predicting and preventing adverse drug reactions in the very old. Drugs Aging 22:375–392
(2015) American Geriatrics Society (2015, 2015) Updated beers criteria for potentially inappropriate medication use in older adults. J Am Geriatr Soc 63:2227–2246. https://doi.org/10.1111/jgs.13702
O’Mahony D, O’Sullivan D, Byrne S et al (2015) STOPP/START criteria for potentially inappropriate prescribing in older people: version 2. Age Ageing 44:213–218
Morgan SG, Hunt J, Rioux J, Proulx J, Weymann D, Tannenbaum C (2016) Frequency and cost of potentially inappropriate prescribing for older adults: a cross-sectional study. CMAJ Open 4:E346–E351. https://doi.org/10.9778/cmajo.20150131
Onder G, van der Cammen TJ, Petrovic M et al (2013) Strategies to reduce the risk of iatrogenic illness in complex older adults. Age Ageing 42:284–291. https://doi.org/10.1093/ageing/aft038
Patterson SM, Cadogan CA, Kerse N, Cardwell CR, Bradley MC, Ryan C, Hughes C, Cochrane Effective Practice and Organisation of Care Group (2014) Interventions to improve the appropriate use of polypharmacy for older people. Cochrane Database Syst Rev (10):CD008165. https://doi.org/10.1002/14651858.CD008165.pub3
Tjia J, Velten S, Parsons C et al (2013) Studies to reduce unnecessary medication use in frail older adults: a systematic review. Drugs Aging 30:285–307. https://doi.org/10.1007/s40266-013-0064-1
Clyne B, Bradley MC, Hughes C, Fahey T, Lapane KL (2012) Electronic prescribing and other forms of technology to reduce inappropriate medication use and polypharmacy in older people: a review of current evidence. Clin Geriatr Med 28:301–322. https://doi.org/10.1016/j.cger.2012.01.009
Raebel MA, Charles J, Dugan J, Carroll NM, Korner EJ, Brand DW, Magid DJ (2007) Randomized trial to improve prescribing safety in ambulatory elderly patients. J Am Geriatr Soc 55:977–985. https://doi.org/10.1111/j.1532-5415.2007.01202.x
Tamblyn R, Huang A, Perreault R, Jacques A, Roy D, Hanley J, McLeod P, Laprise R (2003) The medical office of the 21st century (MOXXI): effectiveness of computerized decision-making support in reducing inappropriate prescribing in primary care. Can Med Assoc J 169:549–556
Tamblyn R, Eguale T, Buckeridge DL, Huang A, Hanley J, Reidel K, Shi S, Winslade N (2012) The effectiveness of a new generation of computerized drug alerts in reducing the risk of injury from drug side effects: a cluster randomized trial. J Am Med Inform Assoc 19:635–643. https://doi.org/10.1136/amiajnl-2011-000609
Fried TR, Niehoff KM, Street RL, Charpentier PA, Rajeevan N, Miller PL, Goldstein MK, O’Leary JR, Fenton BT (2017) Effect of the tool to reduce inappropriate medications on medication communication and deprescribing. J Am Geriatr Soc 65:2265–2271. https://doi.org/10.1111/jgs.15042
Vanderman AJ, Moss JM, Bryan WE et al (2017) Evaluating the impact of medication safety alerts on prescribing of potentially inappropriate medications for older veterans in an ambulatory care setting. J Pharm Pract 30:82–88. https://doi.org/10.1177/0897190015621803
Cossette B, Bergeron J, Ricard G, Éthier JF, Joly-Mischlich T, Levine M, Sene M, Mallet L, Lanthier L, Payette H, Rodrigue MC, Brazeau S (2016) Knowledge translation strategy to reduce the use of potentially inappropriate medications in hospitalized elderly adults. J Am Geriatr Soc 64:2487–2494. https://doi.org/10.1111/jgs.14322
Cossette B, Éthier J-F, Joly-Mischlich T, Bergeron J, Ricard G, Brazeau S, Caron M, Germain O, Payette H, Kaczorowski J, Levine M (2017) Reduction in targeted potentially inappropriate medication use in elderly inpatients: a pragmatic randomized controlled trial. Eur J Clin Pharmacol 73:1237–1245. https://doi.org/10.1007/s00228-017-2293-4
Arvisais K, Bergeron-Wolff S, Bouffard C, Michaud AS, Bergeron J, Mallet L, Brazeau S, Joly-Mischlich T, Bernier-Filion N, Lanthier L, Ricard G, Rodrigue MC, Cossette B (2015) A pharmacist–physician intervention model using a computerized alert system to reduce high-risk medication use in elderly inpatients. Drugs Aging 32:663–670. https://doi.org/10.1007/s40266-015-0286-5
Graham ID, Logan J, Harrison MB, Straus SE, Tetroe J, Caswell W, Robinson N (2006) Lost in knowledge translation: time for a map? J Contin Educ Heal Prof 26:13–24. https://doi.org/10.1002/chp.47
Alagiakrishnan K, Wilson P, Sadowski CA, Rolfson D, Ballerman M, Ausford A, Vermeer K, Mohindra K, Romney J, Hayward R (2016) Physicians’ use of computerized clinical decision supports to improve medication management in the elderly - the seniors medication alert and review technology intervention. Clin Interv Aging 11:73–81. https://doi.org/10.2147/cia.s94126
Acknowledgments
The authors are grateful to Martin St-Jean for his help in the data transfer from the Electronic Medical Record to the Computerized Alert System and to Danielle Buch, a medical writer, for a quick edit of the manuscript.
Funding
This study was funded partially through a grant received from the Fondation Vitae of the CIUSSS de l’Estrie-CHUS. The funding source had no involvement in the study design, data collection, analysis, or interpretation; the writing of the report; or the decision to submit the report for publication.
Author information
Authors and Affiliations
Contributions
Benoit Cossette, Ryeyan Taseen, Jacynthe Roy-Petit, Geneviève Ricard, and Jean-François Éthier designed the study; Benoit Cossette, Ryeyan Taseen, Jacynthe Roy-Petit, Martine Grondin, François Goyer, and Jean-François Éthier acquired and analyzed the data; interpreted the data; Benoit Cossette and Ryeyan Taseen drafted the manuscript; Jacynthe Roy-Petit, Marie-Pier Villemure, Martine Grondin, Geneviève Ricard, François Goyer, Caroline Blanchard, Thomas Joly-Mischlich, and Jean-François Éthier critically revised the manuscript.
Corresponding author
Ethics declarations
Conflict of interest
The authors declare they have no conflicts of interest.
Ethics approval
This study was approved by the CIUSSS de l’Estrie-CHUS Research Ethics Board.
Additional information
Publisher’s note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Electronic supplementary material
ESM 1
(PDF 390 kb)
Rights and permissions
About this article
Cite this article
Cossette, B., Taseen, R., Roy-Petit, J. et al. A pharmacist-physician intervention model using a computerized alert system to reduce high-risk medication use in primary care. Eur J Clin Pharmacol 75, 1017–1023 (2019). https://doi.org/10.1007/s00228-019-02660-x
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00228-019-02660-x