Abstract
Background
The incidence of cytarabine-induced pericarditis is rare. So far, only a few cases have been reported worldwide.
Description of the case
We are reporting a case of a 25-year-old male with acute myeloid leukemia (AML M2a) on chemotherapy who developed acute pericarditis after the administration of a cytarabine-containing regimen. The symptoms gradually improved after symptomatic treatment with steroids and other drugs.
Conclusions
This case demonstrates that, although pericarditis induced by cytarabine is rare, early recognition of this potentially life-threatening complication and appropriate management will usually result in the patient’s recovery.
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References
Rassiga AL, Schwartz HJ, Forman WB et al (1980) Cytarabine-induced anaphylaxis. Demonstration of antibody and successful desensitization. Arch Intern Med 140(3):425–426
Blanca M, Torres MJ, Girón M et al (1997) Successful administration of cytarabine after a previous anaphylactic reaction. Allergy 52(10):1009–1011
O’Donnell MR, Tallman MS, Abboud CN et al (2017) Acute myeloid leukemia, version 3.2017, NCCN clinical practice guidelines in oncology. J Natl Compr Canc Netw 15(7):926–857
Pfizer (2014) Idamycin PFS (idarubicin hydrochloride injection). Prescribing information. Pfizer, New York, NY
Woods T, Vidarsson B, Mosher D et al (1999) Transient effusive-constrictive pericarditis due to chemotherapy. Clin Cardiol 22(4):316–318
Hermans C, Straetmans N, Michaux J-L et al (1997) Pericarditis induced by high-dose cytosine arabinoside chemotherapy. Ann Hematol 75(1–2):55–57
Gillis S, Dann EJ, Ilan Y et al (1992) Pericarditis associated with high-dose cytarabine therapy for acute myeloblasts leukemia: a rare complication of therapy. Leuk Lymphoma 6:525–526
Vaickus L, Letendre L (1984) Pericarditis induced by high-dose cytarabine therapy. Arch Intern Med 144(9):1868–1869
Reykdal S, Sham R, Kouides P (1995) Cytarabine-induced pericarditis: a case report and review of the literature of the cardio-pulmonary complications of cytarabine therapy. Leuk Res 19(2):141–144
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Yang, X., Liu, W., Lyons, A. et al. Pericarditis associated with cytarabine therapy for acute myelocytic leukemia: a case report. Eur J Clin Pharmacol 74, 181–182 (2018). https://doi.org/10.1007/s00228-017-2355-7
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DOI: https://doi.org/10.1007/s00228-017-2355-7