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Altered Bone Remodeling in Psoriatic Disease: New Insights and Future Directions

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Abstract

Psoriatic arthritis (PsA) is an inflammatory rheumatic disorder that occurs in patients with psoriasis and predominantly affects musculoskeletal structures, skin, and nails. The etiology of PsA is not well understood but evidence supports an interplay of genetic, immunologic, and environmental factors which promote pathological bone remodeling and joint damage in PsA. Localized and systemic bone loss due to increased activity of osteoclasts is well established in PsA based on animal models and translational studies. In contrast, the mechanisms responsible for pathological bone remodeling in PsA remain enigmatic although new candidate molecules and pathways have been identified. Recent reports have revealed novel findings related to bone erosion and pathologic bone formation in PsA. Many associated risk factors and contributing molecular mechanisms have also been identified. In this review, we discuss new developments in the field, point out unresolved questions regarding the pathogenetic origins of the wide array of bone phenotypes in PsA, and discuss new directions for investigation.

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Funding

Ananta Paine’s research works are supported by Health Sciences Research Using High Performance Computational Resources (HSCCI) Pilot Grant, Lung Biology Strategic Plan High Risk Project Pilot Research Award, and Department of Medicine Research Pilot Projects Award from University of Rochester. Christopher Ritchlin’s research works are supported by funds from the National Institutes of Health (NIH) AR0169000, P30AR069655, and 5UL1TR000042-09 Grants.

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  1. Allergy, Immunology & Rheumatology Division, University of Rochester Medical Center, Rochester, NY, 14623, USA

    Ananta Paine & Christopher Ritchlin

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Correspondence to Ananta Paine.

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Christopher Ritchlin has research grants from Amgen, Abbvie, and UCB. He is also a consultant for Amgen, Abbvie, Boehringer Ingelheim, Celgene, Janssen, and Novartis. Ananta Paine has no conflicts of interest.

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Paine, A., Ritchlin, C. Altered Bone Remodeling in Psoriatic Disease: New Insights and Future Directions. Calcif Tissue Int 102, 559–574 (2018). https://doi.org/10.1007/s00223-017-0380-2

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