The combined impact of sauerkraut with Leuconostoc mesenteroides to enhance immunomodulatory activity in Escherichia coli-infected mice


This study investigated the combined impact of sauerkraut and Leuconostoc mesenteroides culture on immunomodulatory activity in experimental animal. The in vivo immunomodulatory activity of Escherichia coli-infected Balb-C mice was ascertained in fermented sauerkrauts [test vs. control]. Both sauerkrauts enhanced the adaptive immune response [evidenced by an increase in CD4+ CD8+ IFN-γ, TNFα] and innate immune response [represented by a decrease of CD68-IL-6]. Nevertheless, the in vivo immunomodulatory activity of sauerkraut combined with L. mesenteroides was higher than that shown in sauerkraut control solely.

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This work was financially supported through Professor Research Grant, Brawijaya University, with contract number of 2571/UN10.F10/PN/2019.

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Correspondence to Elok Zubaidah.

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Zubaidah, E., Susanti, I., Yuwono, S.S. et al. The combined impact of sauerkraut with Leuconostoc mesenteroides to enhance immunomodulatory activity in Escherichia coli-infected mice. Eur Food Res Technol (2020).

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  • Immunomodulatory activity
  • Sauerkraut
  • Leuconostoc mesenteroides
  • Mice