Analytical and Bioanalytical Chemistry

, Volume 410, Issue 29, pp 7663–7670 | Cite as

Porous Co3O4 nanosheets as a high-performance non-enzymatic sensor for glucose detection

  • Fuyan Liu
  • Peng WangEmail author
  • Qianqian Zhang
  • Zeyan Wang
  • Yuanyuan Liu
  • Zhaoke Zheng
  • Xiaoyan Qin
  • Xiaoyang Zhang
  • Ying Dai
  • Lu Li
  • Baibiao HuangEmail author
Research Paper


Novel porous Co3O4 nanosheets (NSs) were synthesized on the flexible carbon cloth (CC) substrate by a facile hydrothermal method and applied to construct a non-enzymatic sensor for glucose detection. The sensor is based on the electro-catalytic oxidation of glucose on the surface of Co3O4 NSs. Since this particular nanostructure can provide large surface area and more active sites, the Co3O4 NSs non-enzymatic sensor exhibits excellent analytical performance, such as a high sensitivity (8506 μA mM−1 cm−2), a fast response time (less than 6 s), low detection limit of 1 μM, good selectivity, and long-term stability. The results suggest that the porous Co3O4 NSs have great potential applications in the development of sensors for enzyme-free detection of glucose.


Co3O4 nanosheets Non-enzymatic sensor Glucose High sensitivity 


Funding information

This work was financially supported by the National Natural Science Foundation of China (No. 51602179, 21333006, 21573135, 11374190, and 21675104), the National Basic Research Program of China (973 Program, No. 2013CB632401), Recruitment Program for Young Professionals and China and Taishan Scholar Foundation of Shandong Province, China.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no competing interests.

Human and animal rights and informed consent

This work does not contain any studies with human participants or animals performed by any of the authors.

Supplementary material

216_2018_1380_MOESM1_ESM.pdf (779 kb)
ESM 1 (PDF 778 kb)


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Fuyan Liu
    • 1
  • Peng Wang
    • 1
    Email author
  • Qianqian Zhang
    • 1
  • Zeyan Wang
    • 1
  • Yuanyuan Liu
    • 1
  • Zhaoke Zheng
    • 1
  • Xiaoyan Qin
    • 1
  • Xiaoyang Zhang
    • 1
  • Ying Dai
    • 2
  • Lu Li
    • 3
  • Baibiao Huang
    • 1
    Email author
  1. 1.State Key Lab of Crystal MaterialsShandong UniversityJinanChina
  2. 2.School of PhysicsShandong UniversityJinanChina
  3. 3.College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Collaborative Innovation Center of Functionalized Probes for Chemical ImagingShandong Normal UniversityJinanChina

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