Rapid characterization of cocaine in illicit drug samples by 1D and 2D NMR spectroscopy
Seized samples of illegally produced cocaine have a very large variability in composition; a fact that may result in a challenge to their analysis. We demonstrate here a simple and fast method to detect the presence of cocaine in both hydrochloride and free-base forms in illicit drug samples by nuclear magnetic resonance (NMR) spectroscopy. This is achieved by combining the commonly used 1D spectra and diffusion-ordered spectroscopy and introducing the 2D maximum-quantum NMR approach to forensic analysis. The protocol allows the facile determination of the cocaine forms even in the presence of multiple adulterants. By relying on non-uniform sampling acceleration of 2D spectroscopy, the identification can be obtained in less than 3 min for 10 mg of product. Moreover, we show that intermolecular interactions of the sample constituents, while affecting the analysis result, do not interfere with the quality of the detection of the proposed protocol.
KeywordsDOSY NMR MaxQ-NMR 1H-NMR Cocaine Adulterants
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Conflict of interest
The authors declare that they have no conflict of interest.
- 1.Recommended Methods for the Identification and Analysis of Cannabis and Cannabis Products. In: Vienna LaSSUNOoDaC, editor. Manual for use by national drug analysis laboratories. New York: UNITED NATIONS, New York; 2012.Google Scholar
- 13.Tanner JE. Use of the stimulated echo in NMR diffusion studies. J Chem Phys. 1970;52. https://doi.org/10.1063/1.1673336.