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Advances in the analysis of biological samples using ionic liquids

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Abstract

Ionic liquids are a class of solvents and materials that hold great promise in bioanalytical chemistry. Task-specific ionic liquids have recently been designed for the selective extraction, separation, and detection of proteins, peptides, nucleic acids, and other physiologically relevant analytes from complex biological samples. To facilitate rapid bioanalysis, ionic liquids have been integrated in miniaturized and automated procedures. Bioanalytical separations have also benefited from the modification of nonspecific magnetic materials with ionic liquids or the implementation of ionic liquids with inherent magnetic properties. Furthermore, the direct detection of the extracted molecules in the analytical instrument has been demonstrated with structurally tuned ionic liquids and magnetic ionic liquids, providing a significant advantage in the analysis of low-abundance analytes. This article gives an overview of these advances that involve the application of ionic liquids and derivatives in bioanalysis.

Ionic liquids, magnetic ionic liquids, and ionic liquid-based sorbents are increasing the speed, selectivity, and sensitivity in the analysis of biological samples

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Acknowledgements

JLA acknowledges funding from the Chemical Measurement and Imaging Program at the National Science Foundation (grant no. CHE-1709372).

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Authors and Affiliations

  1. Department of Chemistry, Iowa State University, 1605 Gilman Hall, Ames, IA, 50011, USA

    Kevin D. Clark, María J. Trujillo-Rodríguez & Jared L. Anderson

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  1. Kevin D. Clark
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  2. María J. Trujillo-Rodríguez
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  3. Jared L. Anderson
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Correspondence to Jared L. Anderson.

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The authors declare that they have no competing interests.

Additional information

Published in the topical collection Ionic Liquids as Tunable Materials in (Bio)Analytical Chemistry with guest editors Jared L. Anderson and Kevin D. Clark.

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Clark, K.D., Trujillo-Rodríguez, M.J. & Anderson, J.L. Advances in the analysis of biological samples using ionic liquids. Anal Bioanal Chem 410, 4567–4573 (2018). https://doi.org/10.1007/s00216-018-0898-9

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  • DOI: https://doi.org/10.1007/s00216-018-0898-9

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