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Advanced bioanalytics for precision medicine

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Abstract

Precision medicine is a new paradigm that combines diagnostic, imaging, and analytical tools to produce accurate diagnoses and therapeutic interventions tailored to the individual patient. This approach stands in contrast to the traditional “one size fits all” concept, according to which researchers develop disease treatments and preventions for an “average” patient without considering individual differences. The “one size fits all” concept has led to many ineffective or inappropriate treatments, especially for pathologies such as Alzheimer’s disease and cancer. Now, precision medicine is receiving massive funding in many countries, thanks to its social and economic potential in terms of improved disease prevention, diagnosis, and therapy. Bioanalytical chemistry is critical to precision medicine. This is because identifying an appropriate tailored therapy requires researchers to collect and analyze information on each patient’s specific molecular biomarkers (e.g., proteins, nucleic acids, and metabolites). In other words, precision diagnostics is not possible without precise bioanalytical chemistry. This Trend article highlights some of the most recent advances, including massive analysis of multilayer omics, and new imaging technique applications suitable for implementing precision medicine.

Precision medicine combines bioanalytical chemistry, molecular diagnostics, and imaging tools for performing accurate diagnoses and selecting optimal therapies for each patient.

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Acknowledgments

The authors thank Miss Grace Fox who proofread and copyedited the manuscript.

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Authors and Affiliations

  1. Department of Chemistry G. Ciamician, Alma Mater Studiorum, University of Bologna, Via Selmi, 2, 40126, Bologna, Italy

    Aldo Roda, Elisa Michelini, Cristiana Caliceti, Massimo Guardigli & Mara Mirasoli

  2. Istituto Nazionale Biostrutture e Biosistemi (INBB), 00136, Rome, Italy

    Aldo Roda, Elisa Michelini, Cristiana Caliceti & Mara Mirasoli

  3. Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Alma Mater Studiorum, Sant’Orsola Malpighi Hospital, Via Massarenti, 9, 40138, Bologna, Italy

    Patrizia Simoni

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  1. Aldo Roda
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  2. Elisa Michelini
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Correspondence to Aldo Roda.

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Published in the topical collection celebrating ABCs 16th Anniversary.

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Roda, A., Michelini, E., Caliceti, C. et al. Advanced bioanalytics for precision medicine. Anal Bioanal Chem 410, 669–677 (2018). https://doi.org/10.1007/s00216-017-0660-8

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