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Analytical and Bioanalytical Chemistry

, Volume 406, Issue 1, pp 139–161 | Cite as

On-chip processing of particles and cells via multilaminar flow streams

  • Mark D. Tarn
  • Maria J. Lopez-Martinez
  • Nicole PammeEmail author
Review
Part of the following topical collections:
  1. ABC Highlights: authored by Rising Stars and Top Experts

Abstract

The processing of particles, cells, and droplets for reactions, analyses, labeling, and coating is an important aspect of many microfluidic workflows. However, performing multi-step processes is typically a laborious and time-consuming endeavor. By exploiting the laminar nature of flow within microchannels, such procedures can benefit in terms of both speed and simplicity. This can be achieved either by manipulating the flow streams around the objects of interest, particularly for the localized perfusion of cells, or by manipulating the objects themselves within the streams via a range of forces. Here, we review the variety of methods that have been employed for performing such “multilaminar flow” procedures on particles, cells, and droplets.

Keywords

Continuous flow Microfluidics Microparticles Cells Droplets Trapping Deflection Multilaminar flow 

Notes

Acknowledgments

The authors thank Sally A. Peyman, Giuseppe Benazzi, and Alexander Iles for proofreading.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Mark D. Tarn
    • 1
  • Maria J. Lopez-Martinez
    • 1
  • Nicole Pamme
    • 1
    Email author
  1. 1.Department of ChemistryThe University of HullHullUK

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