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Ultra-trace analysis of platinum in human tissue samples

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Abstract

Background levels of platinum were determined in human autopsy tissues taken from five individuals. The investigated specimens were lung, liver and kidney. Sample preparation involved microwave digestion followed by an open vessel treatment. Inductively-coupled plasma sector field mass spectrometry (ICP-SFMS) was applied in combination with an ultrasonic nebulization/membrane desolvation system for sample introduction. Isotope dilution analysis was employed for accurate quantification of platinum. Excellent procedural detection limits (3 s validation) of 20, 20 and 34 pg g−1 dry weight were obtained for lung, liver and kidney tissue, respectively. Due to the lack of appropriate biological reference material, road dust (BCR-723) was used for method validation. Platinum levels ranging between 0.03 and 1.42 ng g−1 were determined in the investigated samples. The platinum concentrations observed in human lung tissue may reflect the increasing atmospheric background levels of platinum originating from car catalysts. The presence of platinum in kidney and liver tissue samples clearly indicates the bioavailability of the element.

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Acknowledgements

We gratefully acknowledge the financial support by the Austrian National Bank (Project Number: 9561, Human Biomonitoring of Platinum Group Elements).

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Authors and Affiliations

  1. Department of Chemistry, BOKU—University of Natural Resources and Applied Life Sciences, Muthgasse 18, 1190, Vienna, Austria

    Elisabeth Rudolph, Stephan Hann & Gerhard Stingeder

  2. Department of Forensic Medicine, Medical University Vienna, Sensengasse 2, 1090, Vienna, Austria

    Christian Reiter

Authors
  1. Elisabeth Rudolph
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  2. Stephan Hann
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  3. Gerhard Stingeder
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  4. Christian Reiter
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Correspondence to Stephan Hann.

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Rudolph, E., Hann, S., Stingeder, G. et al. Ultra-trace analysis of platinum in human tissue samples. Anal Bioanal Chem 382, 1500–1506 (2005). https://doi.org/10.1007/s00216-005-3370-6

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  • DOI: https://doi.org/10.1007/s00216-005-3370-6

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