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Psychopharmacology

, Volume 235, Issue 2, pp 419–432 | Cite as

Do psychoactive drugs have a therapeutic role in compulsivity? Studies on schedule-induced polydipsia

  • Elena Martín-González
  • Ángeles Prados-Pardo
  • Santiago Mora
  • Pilar Flores
  • Margarita Moreno
Original Investigation

Abstract

Rationale

Clinical studies have shown that some psychoactive recreational drugs have therapeutic applications in anxiety, depression, and schizophrenia. However, to date, there are few studies on the therapeutic potential efficacy of recreational drugs in compulsive neuropsychiatric disorders.

Objectives

We explored the therapeutic potential of different psychoactive and psychedelic drugs in a preclinical model of compulsive behavior.

Methods

Outbred male Wistar rats were selected as either high (HD) or low (LD) drinkers according to their behavior in schedule-induced polydipsia (SIP). Subsequently, we assessed the effects of acute administration of scopolamine (0.125, 0.25, and 0.5 mg/kg), methamphetamine (0.25, 0.5, 1.25, and 2.5 mg/kg), ketamine (1.25, 2.5, 5, and 10 mg/kg), cannabidiol (1 and 3 mg/kg), WIN21255–2 (0.5, 075, and 1 mg/kg), and AM404 (0.25 and 0.5 mg/kg) on compulsive drinking in SIP.

Results

Scopolamine reduced dose-dependent compulsive drinking in HD compared with LD rats in SIP. Methamphetamine induced a dose-dependent inverted U-curve effect in both groups, in which lower doses increased and higher doses reduced compulsive drinking in SIP. Ketamine, cannabidiol, WIN21255-2, and AM404 did not have any relevant effects in SIP.

Conclusions

These data provide new evidence that low doses of scopolamine and intermediate doses of methamphetamine might therapeutically reduce compulsive behaviors and suggest that there is not a direct participation of the endocannabinoid system in compulsive behavior on SIP. The research in the underlying neurochemical mechanisms of these psychoactive drugs might provide an additional insight on new therapeutic targets in compulsive neuropsychiatric disorders.

Keywords

Compulsivity Schedule-induced polydipsia Psychoactive drugs Psychedelic drugs 

Notes

Acknowledgements

This work was supported by grants from the Ministerio de Economía y Competitividad, Spanish Government (grant number PSI2015-70037-R MINECO-FEDER).

Compliance with ethical standards

Conflict of interest

The authors declared that they have no conflicts of interest.

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© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Psychology and CIAIMBITAL, CeiA3University of AlmeríaAlmeríaSpain

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