Naunyn-Schmiedeberg's Archives of Pharmacology

, Volume 391, Issue 3, pp 235–245 | Cite as

Impact of diet restriction in the management of diabetes: evidences from preclinical studies

  • Pawan Krishan
  • Onkar Bedi
  • Monika Rani


The inappropriate dietary habits lead to the onset of age-related pathologies which include diabetes and cardiovascular ailments. Dietary restriction and nutritional therapy play an important role in the prevention of these chronic ailments. Preclinical research provides a basis for the therapeutic exploration of new dietary interventions for the clinical trials to potentiate the scientific management of diabetes and its related complications which further help in translating these nutritional improvements from bench to bedside. Within the same context, numerous therapeutically proved preclinical dietary interventions like high-fiber diet, caloric restriction, soy isoflavone-containing diets, etc., have shown the promising results for the management of diabetes and the associated complications. The focus of the present review is to highlight the various preclinical evidences of diet restriction for the management of diabetes and which will be helpful for enlightening the new ideas of nutritional therapy for future research exploration. In addition, some potential approaches are also discussed which are associated with various nutritional interventions to combat progressive diabetes and the associated disorders.

Graphical abstract


Dietary restriction (DR) Hyperinsulinemia Nutrition therapy Caloric restriction (CR) 



Advanced glycation end products


AMP-activated protein kinase


Caloric restriction


Diabetic nephropathy


Deoxyribonucleic acid


Dietary restriction


Exercise training


Glucose transporter 2


Hemoglobin A1c or glycated hemoglobin


High-density lipoprotein


High-fat diet


Insulin-like growth factor 1


Ketogenic diet


Low-carbohydrate ketogenic diet


Low-density lipoprotein


Low-fat soy milk powder




Medical nutrition therapy


Mammalian target of rapamycin complex 1


Nicotinamide adenine dinucleotide


Otsuka-Long-Evans-Tokushima fatty


Peroxisome proliferator-activated receptor






Type 2 diabetes mellitus




World Health Organization



We want to acknowledge the Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala and UGC, New Delhi for extending the necessary research facilities for our work. We also want to acknowledge Elegant Foreign Language Institute (EFLI) IELTS Institute Sunam, Punjab, India for English writing and editing.

Funding information

The authors are thankful to DST-SERB, New Delhi for providing financial assistance under project no. EMR/2014/000438 to accomplish this research work.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2017

Authors and Affiliations

  1. 1.Department of Pharmaceutical Sciences and Drug ResearchPunjabi UniversityPatialaIndia
  2. 2.JRF, DST-SERB, New Delhi, Department of Pharmaceutical Sciences and Drug ResearchPunjabi UniversityPatialaIndia
  3. 3.Department of Pharmaceutical Sciences and Drug ResearchPunjabi UniversityPatialaIndia

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