Abstract
The inappropriate dietary habits lead to the onset of age-related pathologies which include diabetes and cardiovascular ailments. Dietary restriction and nutritional therapy play an important role in the prevention of these chronic ailments. Preclinical research provides a basis for the therapeutic exploration of new dietary interventions for the clinical trials to potentiate the scientific management of diabetes and its related complications which further help in translating these nutritional improvements from bench to bedside. Within the same context, numerous therapeutically proved preclinical dietary interventions like high-fiber diet, caloric restriction, soy isoflavone-containing diets, etc., have shown the promising results for the management of diabetes and the associated complications. The focus of the present review is to highlight the various preclinical evidences of diet restriction for the management of diabetes and which will be helpful for enlightening the new ideas of nutritional therapy for future research exploration. In addition, some potential approaches are also discussed which are associated with various nutritional interventions to combat progressive diabetes and the associated disorders.
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Abbreviations
- AGES:
-
Advanced glycation end products
- AMPK:
-
AMP-activated protein kinase
- CR:
-
Caloric restriction
- DN:
-
Diabetic nephropathy
- DNA:
-
Deoxyribonucleic acid
- DR:
-
Dietary restriction
- ET:
-
Exercise training
- GLUT2:
-
Glucose transporter 2
- HbAIC:
-
Hemoglobin A1c or glycated hemoglobin
- HDL:
-
High-density lipoprotein
- HFD:
-
High-fat diet
- IGF-1:
-
Insulin-like growth factor 1
- KD:
-
Ketogenic diet
- LCKD:
-
Low-carbohydrate ketogenic diet
- LDL:
-
Low-density lipoprotein
- LFSMP:
-
Low-fat soy milk powder
- MDA:
-
Malondialdehyde
- MNT:
-
Medical nutrition therapy
- mTORC1:
-
Mammalian target of rapamycin complex 1
- NAD+:
-
Nicotinamide adenine dinucleotide
- OLETF:
-
Otsuka-Long-Evans-Tokushima fatty
- PPAR:
-
Peroxisome proliferator-activated receptor
- SIRT:
-
Sirtuins
- STZ:
-
Streptozotocin
- T2DM:
-
Type 2 diabetes mellitus
- TG:
-
Triglyceride
- WHO:
-
World Health Organization
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Acknowledgements
We want to acknowledge the Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala and UGC, New Delhi for extending the necessary research facilities for our work. We also want to acknowledge Elegant Foreign Language Institute (EFLI) IELTS Institute Sunam, Punjab, India for English writing and editing.
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The authors are thankful to DST-SERB, New Delhi for providing financial assistance under project no. EMR/2014/000438 to accomplish this research work.
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Chemical compounds studied in this article
Streptozotocin (PubChem CID:29327)
Highlights
• Diet restriction has beneficial effects on insulin action and glycemic control in obesity and mild T2DM
• Soy diet shown to produce anti-diabetic effect by acting through the estrogen receptors.
• Preclinical evidences of diet restriction and dietary approaches in the management of diabetes and their associated complications.
• Other highlight of this review is about nutritional interventions which combat progressive diabetes and the associated disorders.
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Krishan, P., Bedi, O. & Rani, M. Impact of diet restriction in the management of diabetes: evidences from preclinical studies. Naunyn-Schmiedeberg's Arch Pharmacol 391, 235–245 (2018). https://doi.org/10.1007/s00210-017-1453-5
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DOI: https://doi.org/10.1007/s00210-017-1453-5