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Argo CK, Caldwell SH (2017) Editorial: Severe acute liver injury: cause connects to outcome. Am J Gastroenterol 112(9):1397–1399. https://doi.org/10.1038/ajg.2017.221
Bernal W, Auzinger G, Dhawan A, Wendon J (2010) Acute liver failure. Lancet 17(376):190–201. https://doi.org/10.1016/S0140-6736(10)60274-7
Ganger DR, Rule J, Rakela J et al (2018) Acute liver failure of indeterminate etiology: a comprehensive systematic approach by an expert committee to establish causality. Am J Gastroenterol 113(9):1319. https://doi.org/10.1038/s41395-018-0160-2
Gao Y, Chu S, Zhang Z et al (2017) Early stage functions of mitochondrial autophagy and oxidative stress in acetaminophen-induced liver injury. J Cell Biochem 118(10):3130–3141. https://doi.org/10.1002/jcb.25788
Ghallab A, Cellière G, Henkel SG et al (2016) Model-guided identification of a therapeutic strategy to reduce hyperammonemia in liver diseases. J Hepatol 64(4):860–871. https://doi.org/10.1016/j.jhep.2015.11.018
Ghallab A, Hofmann U, Sezgin S et al (2019) Bile microinfarcts in cholestasis are initiated by rupture of the apical hepatocyte membrane and cause shunting of bile to sinusoidal blood. Hepatology 69(2):666–683. https://doi.org/10.1002/hep.30213
Godoy P, Hewitt NJ, Albrecht U et al (2013) Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME. Arch Toxicol 87(8):1315–1530. https://doi.org/10.1007/s00204-013-1078-5
Hoehme S, Brulport M, Bauer A et al (2010) Prediction and validation of cell alignment along microvessels as order principle to restore tissue architecture in liver regeneration. Proc Natl Acad Sci USA 107(23):10371–10376. https://doi.org/10.1073/pnas.0909374107
Hoehme S, Friebel A, Hammad S, Drasdo D, Hengstler JG (2017) Creation of three-dimensional liver tissue models from experimental images for systems medicine. Methods Mol Biol 1506:319–362. https://doi.org/10.1007/978-1-4939-6506-9_22
Jansen PL, Ghallab A, Vartak N et al (2017) The ascending pathophysiology of cholestatic liver disease. Hepatology 65(2):722–738. https://doi.org/10.1002/hep.28965
Lee WM (2017) Acetaminophen (APAP) hepatotoxicity-Isn't it time for APAP to go away? J Hepatol 67(6):1324–1331. https://doi.org/10.1016/j.jhep.2017.07.005
Leist M, Ghallab A, Graepel R et al (2017) Adverse outcome pathways: opportunities, limitations and open questions. Arch Toxicol 91(11):3477–3505. https://doi.org/10.1007/s00204-017-2045-3
Li M, Li J, Zeng R et al (2018a) Respiratory syncytial virus replication is promoted by autophagy-mediated inhibition of apoptosis. J Virol 92(8):93–117. https://doi.org/10.1128/JVI.02193-17
Li Q, Qi F, Meng X, Zhu C, Gao Y (2018b) Mst1 regulates colorectal cancer stress response via inhibiting Bnip3-related mitophagy by activation of JNK/p53 pathway. Cell Biol Toxicol 34(4):263–277. https://doi.org/10.1007/s10565-017-9417-6
Ni HM, McGill MR, Chao X et al (2016) Removal of acetaminophen protein adducts by autophagy protects against acetaminophen-induced liver injury in mice. J Hepatol 65(2):354–362. https://doi.org/10.1016/j.jhep.2016.04.025
Reif R, Ghallab A, Beattie L et al (2017) In vivo imaging of systemic transport and elimination of xenobiotics and endogenous molecules in mice. Arch Toxicol 91(3):1335–1352. https://doi.org/10.1007/s00204-016-1906-5
Schenk A, Ghallab A, Hofmann U et al (2017) Physiologically-based modelling in mice suggests an aggravated loss of clearance capacity after toxic liver damage. Sci Rep 7(1):6224. https://doi.org/10.1038/s41598-017-04574-z
Sezgin S, Hassan R, Zühlke S et al (2018) Spatio-temporal visualization of the distribution of acetaminophen as well as its metabolites and adducts in mouse livers by MALDI MSI. Arch Toxicol 92(9):2963–2977. https://doi.org/10.1007/s00204-018-2271-3
Shan S, Shen Z, Zhang C et al (2019) Mitophagy protects against acetaminophen-induced acute liver injury in mice through inhibiting NLRP3 inflammasome activation. Biochem Pharmacol 169:113643. https://doi.org/10.1016/j.bcp.2019.113643
Tan Q, Liu Y, Deng X et al (2020) Autophagy: a promising process for the treatment of acetaminophen-induced liver injury. Arch Toxicol 11:42–65. https://doi.org/10.1007/s00204-020-02780-9
Vartak N, Damle-Vartak A, Richter B et al (2016) Cholestasis-induced adaptive remodeling of interlobular bile ducts. Hepatology 63(3):951–964. https://doi.org/10.1002/hep.28373
Williams JA, Ding WX (2015) Targeting Pink1-Parkin-mediated mitophagy for treating liver injury. Pharmacol Res 102:264–269. https://doi.org/10.1016/j.phrs.2015.09.020
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Hassan, R. Modification of acetaminophen-induced hepatotoxicity by autophagy. Arch Toxicol 94, 2545–2546 (2020). https://doi.org/10.1007/s00204-020-02824-0