Response to comments on: Perinatal exposure to a glyphosate-based herbicide impairs female reproductive outcomes and induces second-generation adverse effects in Wistar rats

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  • 24 June 2020

    We report a mistake in the tables published in Milesi et al. (2019).

References

  1. Alarcón R, Ingaramo PI, Rivera OE, Dioguardi GH, Repetti MR, Demonte LD, Milesi MM, Varayoud J, Muñoz-de-Toro M, Luque EH (2019) Neonatal exposure to a glyphosate-based herbicide alters the histofunctional differentiation of the ovaries and uterus in lambs. Mol Cell Endocrinol 482:45–56

    Article  Google Scholar 

  2. Bates D, Mächler M, Bolker B, Walker S (2015) Fitting linear mixed-effects models using lme4. J Stat Softw 67:1–48

    Article  Google Scholar 

  3. Borges CS, Pacheco TL, Guerra MT, Barros AL, Silva PV, Missassi G, da Silva KP, Anselmo Franci JA, Pupo AS, De Grava KW (2017) Reproductive disorders in female rats after prenatal exposure to betamethasone. J Appl Toxicol 37:1065–1072

    CAS  Article  Google Scholar 

  4. Guerrero Schimpf M, Milesi MM, Ingaramo PI, Luque EH, Varayoud J (2017) Neonatal exposure to a glyphosate based herbicide alters the development of the rat uterus. Toxicology 376:2–14

    CAS  Article  Google Scholar 

  5. Guerrero Schimpf M, Milesi MM, Luque EH, Varayoud J (2018) Glyphosate-based herbicide enhances the uterine sensitivity to estradiol in rats. J Endocrinol 239:197–213

    Article  Google Scholar 

  6. Hu J, Lin H, Shen J, Lan J, Ma C, Zhao Y, Lei F, Xing D, Du L (2011) Developmental toxicity of orally administered pineapple leaf extract in rats. Food Chem Toxicol 49:1455–1463

    CAS  Article  Google Scholar 

  7. Ingaramo PI, Varayoud J, Milesi MM, Guerrero Schimpf M, Muñozde-Toro M, Luque EH (2016) Effects of neonatal exposure to a glyphosate-based herbicide on female rat reproduction. Reproduction 152:403–415

    Article  Google Scholar 

  8. Ingaramo PI, Varayoud J, Milesi MM, Guerrero Schimpf M, Alarcón R, Muñoz-de-Toro M, Luque EH (2017) Neonatal exposure to a glyphosate-based herbicide alters uterine decidualization in rats. Reprod Toxicol 73:87–95

    CAS  Article  Google Scholar 

  9. Lazic SE, Essioux L (2013) Improving basic and translational science by accounting for litter-to-litter variation in animal models. BMC Neurosci 14:37

    Article  Google Scholar 

  10. Lima de Barros A, Rosa JL, Cavariani MM, Borges CS, Villela-Silva P, Bae JH, Anselmo-Franci JA, Cristina-Arena A (2016) In utero and lactational exposure to fipronil in female rats: Pregnancy outcomes and sexual development. J Toxicol Environ Health A 79:266–273

    CAS  Article  Google Scholar 

  11. Lorenz V, Milesi MM, Guerrero Schimpf M, Luque EH, Varayoud J (2019) Epigenetic disruption of estrogen receptor alpha is induced by a glyphosate-based herbicide in the preimplantation uterus of rats. Mol Cell Endocrinol 480:133–141

    CAS  Article  Google Scholar 

  12. McNamee R (2005) Regression modelling and other methods to control confounding. Occup Environ Med 62:500–506

    CAS  Article  Google Scholar 

  13. Milesi MM, Lorenz V, Pacini G, Repetti MR, Demonte LD, Varayoud J, Luque EH (2018) Perinatal exposure to a glyphosate-based herbicide impairs female reproductive outcomes and induces second-generation adverse effects in Wistar rats. Arch Toxicol 92:2629–2643

    CAS  Article  Google Scholar 

  14. Paumgartten FJ (2019) Comment on ‘Perinatal exposure to a glyphosate-based herbicide impairs female reproductive outcomes and induces second-generation adverse effects in Wistar rats’. Arch Toxicol 93:831–832

    CAS  Article  Google Scholar 

  15. Plewis I (2019) Comment on: Perinatal exposure to a glyphosate-based herbicide impairs female reproductive outcomes and induces second-generation adverse effects in Wistar rats. Arch Toxicol 93:207

    CAS  Article  Google Scholar 

  16. Salewski E (1964) Farbemethoden zum mikroskopischen Nachweis von Implantationsstellen am Uterus der Ratte. Naunyn Schmiedebergs Arch Exp Pathol Pharmakol 247:367

    Article  Google Scholar 

  17. Xie J, Funk J, Bopst M, Ottaviani G, Downes N, Hackford S, Villabruna L, Schmitt G, Barrow P (2018) An innovative investigative approach to characterize the effects observed in a combined fertility study in male and female rats. Regul Toxicol Pharmacol 95:339–347

    CAS  Article  Google Scholar 

Download references

Funding

The study was funded by The Argentine National Agency of Scientific and Technological Promotion (ANPCyT) (PICT 2014 No 2125, PICT 2014 No 1522, PICT 2014 No 1628), CONICET fellowship, CAI+D—Universidad Nacional del Litoral (PIC 50420150100085LI).

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Correspondence to María M. Milesi.

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Milesi, M.M., Lorenz, V., Beldomenico, P.M. et al. Response to comments on: Perinatal exposure to a glyphosate-based herbicide impairs female reproductive outcomes and induces second-generation adverse effects in Wistar rats. Arch Toxicol 93, 3635–3638 (2019). https://doi.org/10.1007/s00204-019-02609-0

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