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Table 2 Uterotrophic relative potencies calculated* from values reported in the literature

From: Human-relevant potency threshold (HRPT) for ERα agonism

  1. *Unless provided in the publication, Relative Potencies (RP) were derived by dividing an EC% value (listed or estimated) of the reference chemical 1,2,3 by the equivalent EC% value (listed or estimated) of each test chemical. EC% values were either extracted from tables or interpolated from figures. Where necessary, concentrations were adjusted to better approximate equivalent EC% values. ND not different than control
  2. 1Estradiol-17β (E2) used as reference chemical for calculation of relative potencies
  3. 2Ethinyl estradiol-17α (EE) used as reference chemical for calculation of relative potencies
  4. 3Diethylstilbestrol (DES) used as reference chemical for calculation of relative potencies
  5. aHigh content of genistin/genistein/glycitein
  6. bLow content of genistin/genistein/glycitein
  7. AJefferson et al. (2002). CD-I immature mice; SQ injection; dose range 0.01–1000 000 ng/kg/day
  8. BLomnitski et al. (2003). Immature CD-I mice; SQ injection; 500 and 500,000 μg/kg/day
  9. CSwankar et al. (2012). Ovariectomized Balb/cByJ mice; SQ injection; 5 mg/kg/day
  10. DHe et al. (2003). Ovariectomized B6C3F1 mice; oral dose; 1, 10, 50, 100, 250, 500, 1000 mg/kg
  11. ESong et al. (1999). Immature B6D2F1 mice; oral gavage; 3 mg/day
  12. FSelvarag et al. (2004). Ovariectomized age-matched C57BL/6 mice; SQ injection 0, 4, 8, 12, 20 mg/kg/day or in the diet 0, 500, 1000 ppm for 12 days
  13. GColdham et al. (1997). Prepubertal CFLP mice; SQ injection; DES doses of 0.5, 5, 50 ng; coumestrol doses of 1, 10, 100 μg
  14. HRachon et al. (2007). Ovariectomized SD rats; in diet; 400 mg/kg of chow
  15. JMcKim et al. (2001). Immature Sprague-Dawleyc and Fischer − 344d rats; oral gavage; 10, 50, 100, 250, 500, 1000 mg/kg/day
  16. KYamasaki et al. (2002a). Immature Crj:CD(SD) rats; SQ injection; 0.6 ng/kg/day (EE) − 30 mg/kg/day (Genistein)
  17. LSchmidt et al. (2006). Ovariectomized Wistar rats; oral dose by gastric tube; 100 mg/kg
  18. Mde Lima Toccafondo Vieira et al. (2008). Immature Wistar rats; oral gavage; doses 125, 300, 720, 1730, 4150 mg/kg/day
  19. NPunt et al. (2013). Immature rats, SQ injection of 35 mg/kg/day
  20. OBarlas et al. (2014). Immature Wistar rats; oral gavage; 1, 10, 100 mg/kg/day
  21. PYamasaki et al. 2003. Immature Crj:CD(SD) rats; SQ injection; 0.6 ng/kg/day–40 mg/kg/day
  22. QYamasaki et al. (2002b). Immature Crj:CD(SD) rats; SQ injection; 0.2 ng/kg/day–200 mg/kg/day
  23. RKeiler et al. (2015). Immature Lewis rats; SQ injection; 4 μg/kg/day–15 mg/kg/day, e6-(l,l-dimethylallyl)naringenin
  24. SOverk et al. (2008). Ovariectomized Sprague Dawley rats, 200 g body weight. 50 μg/kg/day E2; 4 mg/kg/day (8-PN); 4-400 mg/kg/day (extracts). Chemicals measured in plasma (< 0.5–3.7 ng/mL), liver (< 2–4.4 ng/g) and mammary gland (< 3–0.6 ng/g). fMetabolite of 8-prenylnaringenin