Archives of Microbiology

, Volume 200, Issue 2, pp 195–201 | Cite as

Mechanisms and improvement of acid resistance in lactic acid bacteria

  • Chao Wang
  • Yanhua Cui
  • Xiaojun Qu


Lactic acid bacteria (LAB) can take advantage of fermentable carbohydrates to produce lactic acid. They are proverbially applied in industry, agricultural production, animal husbandry, food enterprise, pharmaceutical engineering and some other important fields, which are closely related to human life. For performing the probiotic functions, LAB have to face the low pH environment of the gastrointestinal tract. Therefore, acid resistance of LAB is of great importance not only for their own growth, but also for fermentation and preparation of probiotic products. Recent research studies on acid resistance mechanisms of LAB are mainly focused on neutralization process, biofilm and cell density, proton pump, protection of macromolecules, pre-adaptation and cross-protection, and effect of solutes. In this context, biotechnological strategies such as synthetic biology, genome shuffling, high pressure homogenization and adaptive laboratory evolution were also used to improve the acid resistance of LAB to respond to constantly changing low pH environment.


Lactic acid bacteria Acid stress Acid resistance mechanism Biotechnology 



This work was supported by National Nature Science Foundation of China (Grant no. 31371827; 31471712).

Compliance with ethical standards

Conflict of interest

Authors declare no conflict of interest.


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Copyright information

© Springer-Verlag GmbH Germany 2017

Authors and Affiliations

  1. 1.Department of Food Science and Engineering, School of Chemistry and Chemical EngineeringHarbin Institute of TechnologyHarbinPeople’s Republic of China
  2. 2.Institute of MicrobiologyHeilongjiang Academy of SciencesHarbinPeople’s Republic of China

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