Osteoporosis International

, Volume 29, Issue 7, pp 1637–1642 | Cite as

Effects of once-monthly minodronate versus risedronate in osteoporosis patients with rheumatoid arthritis: a 12-month randomized head-to-head comparison

  • K. Kumagai
  • K. Harigane
  • Y. Kusayama
  • T. Tezuka
  • H. Choe
  • Y. Inaba
  • T. Saito
Original Article



A head-to-head comparison of once-monthly oral bisphosphonates minodronate (MIN) and risedronate (RIS) in patients with rheumatoid arthritis (RA) demonstrated that MIN has the same effect as RIS on increase in bone mineral density (BMD) and a stronger effect on inhibition of bone resorption than RIS, suggesting that MIN is a promising treatment option for osteoporosis patients with RA.


To evaluate the effect of once-monthly oral MIN in patients with RA, a prospective, randomized, open-label, head-to-head comparison with once-monthly oral RIS was conducted.


A total of 83 patients with RA were randomly assigned to either once-monthly oral MIN 50 mg (n = 42) or once-monthly oral RIS 75 mg (n = 41). Serial BMD and bone turnover markers were measured and compared between the treatment groups.


BMD (lumbar spine, total hip, femoral neck) increased significantly after 12 months of treatment with MIN (3.8, 2.0, and 2.2%, respectively, P < 0.05) and RIS (3.6, 1.9, and 1.9%, respectively, P < 0.05). There were no significant differences between the treatment groups. Percent changes of bone turnover markers from baseline to 12 months in the MIN group were significantly greater than those in the RIS group (TRACP-5b: − 36.3 vs − 19.3%, P < 0.05; NTX: − 27.1 vs − 17.3%, P < 0.05; BAP: −30.2 vs −19.4%, P < 0.05).


The present study of RA patients demonstrated that MIN has the same effect as RIS on increase in BMD and a stronger effect on inhibition of bone resorption than RIS. The results suggest that MIN is a promising treatment option for osteoporosis patients with RA.


Bone mineral density Bone turnover markers Minodronate Once-monthly oral bisphosphonate Osteoporosis Rheumatoid arthritis Risedronate 


Compliance with ethical standards

The study protocol and publication were approved by the Institutional Review Board at Yokohama City University (no. B120510026). This study was conducted in accordance with the Declaration of Helsinki and written informed consent was obtained from all subjects.

Conflicts of interest



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Copyright information

© International Osteoporosis Foundation and National Osteoporosis Foundation 2018

Authors and Affiliations

  • K. Kumagai
    • 1
  • K. Harigane
    • 1
  • Y. Kusayama
    • 1
  • T. Tezuka
    • 1
  • H. Choe
    • 1
  • Y. Inaba
    • 1
  • T. Saito
    • 1
  1. 1.Department of Orthopaedic Surgery, Graduate School of MedicineYokohama City UniversityYokohamaJapan

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