While kinematic alignment (KA) total knee arthroplasty (TKA) with cemented implants has been shown to provide equivalent or better results than mechanical alignment, its combination with cementless fixation has not yet been documented. The purpose of this study is to report (1) revision rate and causes, (2) clinical results based on patient report outcome measures (PROMs), and (3) radiological signs of implant dysfunction in patients with an uncemented TKA implanted with restricted KA (rKA), after a minimum follow-up of 2 years.
This study included the first 100 consecutive uncemented cruciate retaining TKAs implanted between November 2015 and February 2018 by a single surgeon following rKA principles. At last follow-up, all adverse events and PROMs assessed by WOMAC, KOOS, and FJS scores were documented. Radiographic evaluation was performed to identify signs of implant loosening.
After a mean follow-up of 49 months (32, 60), no implant revision was performed for aseptic loosening. Three revisions were performed: one for malalignment, one for a deep infection, and one for instability. The mean WOMAC score was 20.1 (0–79, 21.3), the mean KOOS score was 71.5 (19.0–96.6, 19.8), and the mean FJS score was 65.9 (0–100, 29.6). No radiological evidence of implant aseptic loosening or osteolysis was identified.
This study shows that in 99% of our cases, rKA combined with the tested cementless TKA implant allowed for adequate secondary fixation and good functional outcomes in the short term. Favourable mid- to long-term implant survivorship is anticipated.
Level of evidence
Total knee arthroplasty (TKA) is the most common joint replacement procedure performed in the world . TKA failure leading to revision is most often the result of aseptic loosening, which occurs at a higher rate in younger patients [9, 29, 33] and in morbidly obese patients [29, 40, 42]. These two groups of patients are thought to subject the implants to greater mechanical stress [3, 23, 40, 44]. To overcome these important challenges, uncemented TKA fixation was proposed to improve long-term fixation [11, 14, 30, 33].
Providing a forgotten TKA remains a challenge, despite important improvements in implant designs, fixation methods, and precision of implantation [8, 16]. This leads to the question whether traditional and systematic mechanical alignment (MA) is the ideal method [17, 36], given that coronal knee alignment varies significantly in both non-arthritic  and arthritic populations . A comprehensive description of different lower limb alignment phenotypes has been proposed by Hirschmann et al. [18,19,20]. Thus, the concept of kinematic alignment (KA) has gained momentum in the last few years because it uses personalized bone resections to recreate the individual pre-arthritic knee anatomy, phenotype, and ligament laxity [2, 35].
KA implies deviating from the systemic neutral lower limb alignment goal of MA and raises the concern that keeping the lower limb in varus will lead to medial compartment overload and tibial component loosening . Furthermore, it is feared that KA non-neutral alignment may jeopardize primary and/or secondary uncemented TKA implant fixation . To our knowledge, all studies reporting KA TKA clinical results included cemented implants, and, therefore, the safety of KA with uncemented implants is still unknown. The purposes of this study are to assess: (1) the revision rate, its causes, and radiological signs of implant dysfunction, (2) the clinical results measured by different patient reported outcome measures (PROMs), and (3) radiographic coronal alignment measurements, after a minimum follow-up of 2 years, in a cohort of 100 patients who underwent a restricted KA (rKA) uncemented TKA. Our hypothesis is that cementless TKA implants can be safely combined with rKA in the short term.
The senior author had been performing rKA since 2011 and implanted his first uncemented cruciate-retaining TKAs (Triathlon Tritanium, Stryker, Mahwah, USA, Fig. 1) in November 2015. By February 2018, the surgeon had performed 133 primary TKAs in his academic practice. Among these, 3 cases were pre-operatively considered inappropriate to receive the studied uncemented CR TKA implant (1 tumoural case requiring a cemented stemmed implant and 2 patients with ligamentous incompetence requiring higher implant constraint) and 27 TKAs were included in another study evaluating a different implant. Of the 103 cases remaining, inaccurate intra-operative femoral bone cuts precluded uncemented implant use in 1 patient, and 2 patients refused to participate in the study. Hence, 100 uncemented TKA cases were included in this study. Patients’ demographics are presented in Table 1. To review patients’ charts and obtain patients’ PROMs at last follow-up, ethics and scientific committee approvals were obtained from our institution, and informed consent was obtained from all participants.
An anterolateral skin incision and medial mid vastus parapatellar arthrotomy without tourniquet were used for all cases. Vendittoli’s rKA protocol was followed, using optical computer navigation (Orthomap ASM, Stryker, MI, USA) (Table 2). Cartilage and bone loss thicknesses were estimated based on comparison with intact areas, and we aimed to restore the patient’s pre-arthritic alignment. For example, in a varus knee, the distal femoral and proximal tibial cut resections were, respectively, set at 8 and 9 mm (implants’ thicknesses) for unworn cartilage surfaces of the lateral femoral condyle and tibial plateau. Then, cartilage wear thickness was assessed on the medial side bone surfaces (no wear = 0 mm, partial cartilage wear = 1 mm, and subchondral bone exposed = 2 mm) . Cut angle was thus adjusted to reach the desired medial resection thickness (example, for a patient with 2 mm of medial tibial wear, a 7-mm medial resection and a 9-mm lateral resection were used). Resections only differed from patient anatomy when the measured angles fell outside the predefined “safe range” as depicted in Fig. 2. To resurface the posterior condyles, a posterior referencing guide was set to neutral rotation, thus resecting only the implant thicknesses on both posterior condyles (no femoral rotation modification). Tibial component rotation was set by its alignment with the trial femoral component with the knee in extension. In the cases where the resection pieces did not appear to match the computer plan or when ligament laxities assessed with trial implants was outside the expected native ligament laxity range , resection accuracy was confirmed by calliper measurements and cut adjustment was performed when needed. The uncemented cruciate-retaining Triathlon (Stryker) prosthesis was implanted in all cases. Its femoral component has a beaded (CrCo) and peri-apatite-coated porous surface, and its tibial component has a porous titanium coating and 4 cruciform pegs for primary fixation (Fig. 1). In selected cases, an uncemented patellar implant backed by porous titanium and with 3 pegs was implanted.
Methods of assessment
All patients were included in our prospective institution database collection system. A retrospective patients’ chart review was performed to seek any adverse events requiring reoperation or revision surgery during the follow-up period. All post-operative radiographs were evaluated following the modern Knee Society Radiographic Evaluation System to assess radiolucent lines, osteolysis, and signs of component loosening . PROMs (WOMAC, KOOS, and Forgotten Joint Scores) were administered in the outpatient clinic at last follow-up by a single research assistant. Radiographic pre- and post-operative coronal orientation measurements were taken using the lateral distal femoral angle (LDFA), the medial proximal tibial angle (MPTA), and the hip–knee–ankle angle (HKA). Using a digitized image and measurement tools, the same evaluator took all measurements as described previously [5, 10, 28, 41].
Sample size calculation using a power of 80%, a p value of < 0.05, and 100 cases, showed that the minimal detectable difference in the revision rate between our cohort and the reported result with cemented rKA would be 7% . Continuous data are presented with mean, minimum, maximum, and standard deviation. Since our number of cases is 100, proportions are presented with percentage alone. Comparisons of the pre-operative and post-operative continuous data were analysed using a paired Student’s T tests. A significance level of p = 0.05 (two-sided) was used for all tests. The analyses were performed using the SPSS software version 26 (SPSS Inc., Chicago, IL, USA).
After a mean post-operative time of 49 months (32–60), 1 patient (2 knees) was deceased from causes unrelated to his TKA and no patient was lost to follow-up. Three TKAs (3%) were revised. One patient, a 76-year-old female fell on stairs 4 weeks after surgery and had a 5° tibial implant valgus shift (Fig. 3). The patient’s persistent discomfort with the malalignment led to revision surgery 13 months after primary implantation. During revision, the tibial implant was well fixed in the valgus malposition and was revised with a cemented implant. One 62-year-old male patient underwent two-stage revision for a deep and chronic infection 21 months after initial surgery (micro-organism was Cutibacterium acnes). Thirty-three months after revision, the patient is free from infection. The final revision was performed on a 78-year-old male patient 9 months after initial surgery for persisting pain and swelling secondary to flexion instability linked to femoral and tibial implants under sizing. During revision, implants were solidly integrated. Increasing the femoral implant size from 3 to 5 with posterior augments and increasing the tibial implant size from 4 to 5 solved his instability symptoms. At last follow-up, radiographic analyses did not reveal evidence of implant loosening, osteolysis, radiolucency, or reactive changes.
At last follow-up, the mean WOMAC score was 20.1 (0–79, 21.3), the mean KOOS score was 71.5 (19.0–96.6, 19.8), and the mean FJS score was 65.9 (0–100, 29.6).
Pre- and post-operative radiographic measurements are provided in Table 1 and fall within expected values according to the rKA protocol.
The most important finding of the present study was that cementless TKA implants can be safely combined with rKA in the short-term, thus supporting our hypothesis. To the best of our knowledge, this is the first study to report results of cementless rKA TKA. In our study, we showed that primary fixation of the implant was sufficient in 99% of cases.
Improving patient satisfaction, function, and survivorship following TKA remains a subject at the forefront of orthopaedic research. This study aimed to report clinical and radiological outcomes of patients who underwent uncemented rKA TKA. Regarding secondary fixation, clinical evaluation and radiographic review after a mean follow-up of 34 months did not show lack of integration or signs of loosening. Even the patient with early mobilisation and malalignment of the tibial component, the implant was well-fixed (osteointegrated) at time of revision.
The optimal implant orientation when performing a TKA remains a pertinent and unanswered question . KA aims to restore the individual’s pre-arthritic or native limb and joint line alignment by resurfacing the knee joint with the intent of reproducing a more natural joint feeling. There is a rapidly growing amount of evidence supporting the safety of this technique. Meta-analyses of available comparative studies have demonstrated either equivalent or favourable early clinical results for cemented TKA KA over MA . Laende et al., using radiostereometric analysis to predict long-term implant survivorship in a randomized controlled trial (RCT) comparing MA to KA cemented TKA, found no difference in implant migration after 2 years . Howell et al. reported a revision rate of 1.5% in 220 cemented KA TKAs at 10 years post-operatively . A combined Australian and New Zealand registry study including 20,512 cases of cemented Triathlon cruciate-retaining TKA reported similar revision rates at 7 years for KA and other alignment techniques . Our study results fall in line with the available literature for MA, which supports rKA as a safe and reliable technique. One case in our study required revision for flexion instability possibly due to undersizing of the femoral and tibial implants. Although review of the surgical protocol did not reveal an obvious reason for this problem, inadvertent anterior translation setting of the posterior referencing femoral sizing guide is suspected.
Deviating from neutral alignment with KA is still a concern for many surgeons . One may suggest that some knee anatomies may be inherently biomechanically inferior and could jeopardize uncemented TKA primary and/or secondary fixation. With persisting uncertainties about joint load and its alignment deviation from neutral, KA combined with cementless implant needed to be tested, particularly because cementless TKA implant fixation posed a challenge to the scientific community for many years [4, 29, 31, 33]. First-generation cementless designs had poor results associated with early loosening; however, contemporary evidence shows survivorship similar to that of cemented implants [31, 43, 44]. The main success factor for this is satisfactory primary fixation with minimal micromotion allowing bone integration to the porous surface [7, 14]. The current study’s revision rate was 3%, and no case revealed aseptic loosening or a lack of secondary integration, thereby once again supporting our hypothesis. Cementless primary fixation as a potential cause of failure was suspected in only one case of implant mobilization after a significant fall in a patient with no known history of osteoporosis but with experience of a periprosthetic fracture following a previous total hip arthroplasty. It is unsure if a cemented fixation would have prevented this issue. In a similar study, following the same rKA principles and implantation technique but with the cemented Triathlon implants, no revisions were required among 100 consecutive and unselected TKAs after a mean follow-up of 2.4 years . In a RCT comparing cemented and uncemented MA Triathlon in 141 patients, Nam et al. found no radiographic evidence of component subsidence or loosening in either cohort at an average of 2 years post-operatively . They reported one revision for deep infection in the cemented group and no revision in the cementless group.
PROMs obtained in our study are similar to those available in the literature for both cemented and cementless MA TKAs or cemented KA TKAs . In the same previously mentioned RCT, Nam et al. found similar PROMs after an average of 2 years for cemented and cementless MA Triathlon TKAs . Miller et al. also demonstrated similar improvements in functional scores between cemented and cementless TKA cohorts . Two systematic reviews of short-term cemented TKAs results found similar or better functional results with KA over MA [13, 26]. This suggests that rKA combined with cementless fixation TKA should provide comparable or better PROMs results than mechanical alignment with cemented or uncemented fixation.
Regarding radiographic analyses, as expected, there was a significant change in standing coronal alignment between pre-operative mean HKA and post-operative mean HKA from 4.9° to 1.4° varus after surgery. The MPTA, LDFA, and HKA mean values, variation, and range reflect the restoration of individual pre-arthritic alignment with rKA boundaries. On the other hand, with recent understanding that lower limb alignment may vary significantly during gait cycle, it remains unclear as to what influence bipodal static alignment has on TKA articular load . Despite not aiming at neutral limb alignment, KA, in gait analyses, produced a lower knee adduction moment and medial tibial compartment load and more normal gait than MA TKA . Studies have found that intra-operative forces in the medial and lateral compartments of patients with outlier alignment were comparable with those with in-range alignment [37,38,39]. In our study, radiographic evaluations conducted at last follow-up did not show signs of a lack of fixation.
Our study has limitations. First, the relatively short-term follow-up is an obvious drawback. However, given that uncemented fixation is the most at risk of failure in the first year, we believe our study’s length was sufficient to capture all instances of short-term failure [4, 7]. Once implant osseointegration is achieved, the risk of implant loosening drops drastically, and therefore, we believe the potential for long-term success is great . Second, this consecutive clinical case series is based on a limited number of patients from only one surgeon using a specific rKA protocol, and thus, the results may not be generalizable to all patient populations. Nevertheless, we believe our selection bias was limited. The patients included in our study were unselected and were subjected to very few exclusion criteria. In particular, age, body mass index (BMI), pre-operative alignment, or joint degeneration severity were not part of the exclusion criteria. Therefore, our patients are expected to correspond to the full spectrum of patients that one would expect to see in a public clinical practice. Finally, collecting data that are recorded in standard practice minimized information bias.
We believe that this study can serve as a stepping stone for other surgeons to combine uncemented fixation and rKA, two methods that have already shown much promise independently and are rapidly gaining popularity.
This study showed that the most crucial period for osseointegration of uncemented TKA was not negatively impacted by our rKA protocol and that favourable mid- to long-term implant survivorship is anticipated. Since this is the first study of its kind, it should be used to promote the adoption of this method and eventually build up the supporting evidence for its continued use.
Body mass index
Forgotten Joint Score
Knee Injury and Osteoarthritis Outcome Score
Lateral distal femoral angle
Medial proximal tibial angle
Randomized controlled trial
Restricted kinematic alignment
Total knee arthroplasty
Western Ontario and McMaster Universities Osteoarthritis Index
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Conflict of interest
Dr P-A Vendittoli declares to be consultant for Ethicon, Johnson & Johnson, and Stryker. Unrestricted research funding is by the institution from Johnson & Johnson, Stryker, and Zimmer.
Ethical approval was obtained from the ethics and scientific committee of our institution.
Informed consent was obtained for all participants.
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The original online version of this article was revised: The image 3c should be 3b and 3b should be 3c. Correct version of figure 3 updated.
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Laforest, G., Kostretzis, L., Kiss, MO. et al. Restricted kinematic alignment leads to uncompromised osseointegration of cementless total knee arthroplasty. Knee Surg Sports Traumatol Arthrosc (2021). https://doi.org/10.1007/s00167-020-06427-1
- Total knee arthroplasty
- Total knee replacement
- Kinematic alignment