Abstract
Purpose
The purpose of this study was to introduce a novel standardized algorithm using SPECT/CT, which promises the potential combined assessment of the biology of the joint in particular the bone-graft-fixation complex and the 3D tunnel placement in patients after ACL reconstruction. Its clinical application and inter- and intra-observer reliability should be critically evaluated.
Methods
A novel SPECT/CT localization scheme consisting of 13 tibial, 9 femoral and 4 patellar regions on standardized axial, coronal and sagittal slices is proposed. The tracer activity on SPECT/CT was localized and recorded in 25 consecutive patients using a 3D volumetric and quantitative analysis software. The inter- and intra-observer reliability was assessed for localization and tracer activity. The tunnel position was assessed in 3D-CT using standardized frames of reference. The inter- and intra-observer reliability (OR) of the measured distances were calculated (ICC).
Results
The localization scheme for tracer uptake analysis was useful and easily applicable in all 25 knees. It showed very high inter-OR and intra-ORs for all regions (ICC > 0.80). Tibial and femoral tunnel position measurements showed strong agreement between the readings of the two observers; the ICCs for the position, angulation, length and entry point of the femoral tunnel were >0.88 (intra-OR) and >0.86 (inter-OR). The ICC for the position of the tibial tunnel (angulation, length and entry point) was >0.79 (intra-OR) and >0.74 (inter-OR).
Conclusions
The SPECT/CT algorithm presented is highly reliable and clinically feasible. Combining the 3D-mechanical information on tunnel placement and attachment areas and the 3D metabolic data will be helpful in evaluating patients with pain after ACL reconstruction.
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References
Basdekis G, Christel P, Anne F (2009) Validation of the position of the femoral tunnels in anatomic double-bundle ACL reconstruction with 3-D CT scan. Knee Surg Sports Traumatol Arthrosc 17:1089–1094
Bencardino JT, Beltran J, Feldman MI, Rose DJ (2009) MR imaging of complications of anterior cruciate ligament graft reconstruction. Radiographics 29:2115–2126
Breunung N, Barwick T, Fernando R, Gnanasegaran G, Vijayanathan S, Hosahalli M, Fogelman I (2008) Additional benefit of SPECT-CT in investigating heel pain. Clin Nucl Med 33:705–706
Foldager C, Jakobsen BW, Lund B, Christiansen SE, Kashi L, Mikkelsen LR, Lind M (2010) Tibial tunnel widening after bioresorbable poly-lactide calcium carbonate interference screw usage in ACL reconstruction. Knee Surg Sports Traumatol Arthrosc 18:79–84
Henckel J, Richards R, Lozhkin K, Harris S, Baena FM, Barrett AR, Cobb JP (2006) Very low-dose computed tomography for planning and outcome measurement in knee replacement. The imperial knee protocol. J Bone Jt Surg Br 88:1513–1518
Hirschmann MT, Adler T, Rasch H, Hugli RW, Friederich NF, Arnold MP (2010) Painful knee joint after ACL reconstruction using biodegradable interference screws- SPECT/CT a valuable diagnostic tool? A case report. Sports Med Arthrosc Rehabil Ther Technol 2:24
Hirschmann MT, Davda K, Iranpour F, Rasch H, Friederich NF (2011) Combined single photon emission computerised tomography and conventional computerised tomography (SPECT/CT) in patellofemoral disorders: a clinical review. Int Orthop 35 675–680
Hirschmann MT, Iranpour F, Davda K, Rasch H, Hugli R, Friederich NF (2009) Combined single-photon emission computerized tomography and conventional computerized tomography (SPECT/CT): clinical value for the knee surgeons? Knee Surg Sports Traumatol Arthrosc 18:341–345
Hirschmann MT, Iranpour F, Konala P, Kerner A, Rasch H, Cobb JP, Friederich NF (2010) A novel standardized algorithm for evaluating patients with painful total knee arthroplasty using combined single photon emission tomography and conventional computerized tomography. Knee Surg Sports Traumatol Arthrosc 18:939–944
Hirschmann MTWR, Rasch H, Henckel J (2012) Standardized volumetric 3D analysis of SPECT/CT imaging in orthopaedics: overcoming the limitations of qualitative 2D analysis. BMC Med Imaging 12:5
Horger M, Eschmann SM, Pfannenberg C, Storek D, Vonthein R, Claussen CD, Bares R (2007) Added value of SPECT/CT in patients suspected of having bone infection: preliminary results. Arch Orthop Trauma Surg 127:211–221
Inoue M, Tokuyasu S, Kuwahara S, Yasojima N, Kasahara Y, Kondo E, Onodere S, Yasuda K (2010) Tunnel location in transparent 3-dimensional CT in anatomic double-bundle anterior cruciate ligament reconstruction with the trans-tibial tunnel technique. Knee Surg Sports Traumatol Arthrosc 18:1176–1183
Iriuchishima T, Tajima G, Ingham SJ, Shen W, Horaguchi T, Saito A, Smolinski P, Fu FH (2009) Intercondylar roof impingement pressure after anterior cruciate ligament reconstruction in a porcine model. Knee Surg Sports Traumatol Arthrosc 17:590–594
Kamath GV, Redfern JC, Greis PE, Burks RT (2011) Revision anterior cruciate ligament reconstruction. Am J Sports Med 39:199–217
Knupp M, Pagenstert GI, Barg A, Bolliger L, Easley ME, Hintermann B (2009) SPECT-CT compared with conventional imaging modalities for the assessment of the varus and valgus malaligned hindfoot. J Orthop Res 27:1461–1466
Lee A, Emmett L, Van der Wall H, Kannangara S, Mansberg R, Fogelman I (2008) SPECT/CT of femeroacetabular impingement. Clin Nucl Med 33:757–762
Nomayr A, Romer W, Strobel D, Bautz W, Kuwert T (2006) Anatomical accuracy of hybrid SPECT/spiral CT in the lower spine. Nucl Med Commun 27:521–528
Purnell ML, Larson AI, Clancy W (2008) Anterior cruciate ligament insertions on the tibia and femur and their relationships to critical bony landmarks using high-resolution volume-rendering computed tomography. Am J Sports Med 36:2083–2090
Scharf S (2009) SPECT/CT imaging in general orthopedic practice. Semin Nucl Med 39:293–307
Trojani C, Sbihi A, Djian P, Potel JF, Hulet C, Jouve F, Bussiere C, Ehkirch FP, Burdin G, Dubrana F, Beaufils P, Franceschi JP, Chassaing V, Colombet P, Neyret P (2011) Causes for failure of ACL reconstruction and influence of meniscectomies after revision. Knee Surg Sports Traumatol Arthrosc 19:196–201
van Eck CF, Kropf EJ, Romanowski JR, Lesniak BP, Tranovich MJ, van Dijk CN, Fu FH (2011) ACL graft re-rupture after double-bundle reconstruction: factors that influence the intra-articular pattern of injury. Knee Surg Sports Traumatol Arthrosc 19:340–346
Walter SD, Eliasziw M, Donner A (1998) Sample size and optimal designs for reliability studies. Stat Med 17:101–110
Acknowledgments
We greatly thank the Deutsche Arthrose Hilfe e.V, Saarlouis, Germany as well as the Alwin-Jäger-Stiftung, Aschaffenburg, Germany for supporting our research and Jürg Schmutz, Bruderholz for his illustrative work.
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Michael T. Hirschmann and Dominic Mathis equally contribution to this work.
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Hirschmann, M.T., Mathis, D., Afifi, F.K. et al. Single photon emission computerized tomography and conventional computerized tomography (SPECT/CT) for evaluation of patients after anterior cruciate ligament reconstruction: a novel standardized algorithm combining mechanical and metabolic information. Knee Surg Sports Traumatol Arthrosc 21, 965–974 (2013). https://doi.org/10.1007/s00167-012-2083-6
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DOI: https://doi.org/10.1007/s00167-012-2083-6