References
Vincent J, Marshall J, Anzueto A et al (2009) International study of the prevalence and outcomes of infection in intensive care units. JAMA J Am Med Assoc 302:2323–2329
Zunt JR, Kassebaum NJ, Blake N et al (2018) Global, regional, and national burden of meningitis, 1990–2016: a systematic analysis for the global burden of disease study 2016. Lancet Neurol 17:1061–1082. https://doi.org/10.1016/S1474-4422(18)30387-9
McGill F, Heyderman RS, Panagiotou S et al (2016) Acute bacterial meningitis in adults. Lancet 388:3036–3047. https://doi.org/10.1016/S0140-6736(16)30654-7
van de Beek D, Cabellos C, Dzupova O et al (2016) ESCMID guideline: diagnosis and treatment of acute bacterial meningitis. Clin Microbiol Infect 22:S37–S62. https://doi.org/10.1016/j.cmi.2016.01.007
Charlier C, Perrodeau É, Leclercq A et al (2017) Clinical features and prognostic factors of listeriosis: the MONALISA national prospective cohort study. Lancet Infect Dis 17:510–519. https://doi.org/10.1016/S1473-3099(16)30521-7
Brouwer MC, Wijdicks EFM, van de Beek D (2016) What’s new in bacterial meningitis. Intensive Care Med 42:415–417. https://doi.org/10.1007/s00134-015-4057-x
Bijlsma MW, Brouwer MC, Spanjaard L et al (2014) A decade of herd protection after introduction of meningococcal serogroup C conjugate vaccination. Clin Infect Dis 59:1216–1221. https://doi.org/10.1093/cid/ciu601
Bijlsma MW, Brouwer MC, Kasanmoentalib ES et al (2016) Community-acquired bacterial meningitis in adults in the Netherlands, 2006–14: a prospective cohort study. Lancet Infect Dis 16:339–347. https://doi.org/10.1016/S1473-3099(15)00430-2
Parikh SR, Andrews NJ, Beebeejaun K et al (2016) Effectiveness and impact of a reduced infant schedule of 4CMenB vaccine against group B meningococcal disease in England: a national observational cohort study. Lancet 388:2775–2782. https://doi.org/10.1016/S0140-6736(16)31921-3
Bonten MJM, Huijts SM, Bolkenbaas M et al (2015) Polysaccharide conjugate vaccine against pneumococcal pneumonia in adults. N Engl J Med 372:1114–1125. https://doi.org/10.1056/NEJMoa1408544
Weinberger DM, Malley R, Lipsitch M (2011) Serotype replacement in disease after pneumococcal vaccination. Lancet 378:1962–1973. https://doi.org/10.1016/S0140-6736(10)62225-8
Waight PA, Andrews NJ, Ladhani SN et al (2015) Effect of the 13-valent pneumococcal conjugate vaccine on invasive pneumococcal disease in England and Wales 4 years after its introduction: an observational cohort study. Lancet Infect Dis 15:535–543. https://doi.org/10.1016/S1473-3099(15)70044-7
Hoogman M, Van De Beek D, Weisfelt M et al (2007) Cognitive outcome in adults after bacterial meningitis. J Neurol Neurosurg Psychiatry 78:1092–1096. https://doi.org/10.1136/jnnp.2006.110023
Auburtin M, Wolff M, Charpentier J et al (2006) Detrimental role of delayed antibiotic administration and penicillin-nonsusceptible strains in adult intensive care unit patients with pneumococcal meningitis: The PNEUMOREA prospective multicenter study. Crit Care Med 34:2758–2765. https://doi.org/10.1097/01.CCM.0000239434.26669.65
Venkatesan A, Tunkel AR, Bloch KC et al (2013) Case definitions, diagnostic algorithms, and priorities in encephalitis: consensus statement of the international encephalitis consortium. Clin Infect Dis 57:1114–1128. https://doi.org/10.1093/cid/cit458
Granerod J, Ambrose HE, Davies NWS et al (2010) Causes of encephalitis and differences in their clinical presentations in England: a multicentre, population-based prospective study. Lancet Infect Dis 10:835–844. https://doi.org/10.1016/S1473-3099(10)70222-X
Da Silva IRF, Frontera JA, De Filippis AMB, >Do Nascimento OJM (2017) Neurologic complications associated with the Zika virus in Brazilian adults. JAMA Neurol 74:1190–1198. https://doi.org/10.1001/jamaneurol.2017.1703
Jaquet P, De Montmollin E, Dupuis C et al (2019) Functional outcomes in adult patients with herpes simplex encephalitis admitted to the ICU: a multicenter cohort study. Intensive Care Med 45:1103–1111. https://doi.org/10.1007/s00134-019-05684-0
Tan IL, McArthur JC, Venkatesan A, Nath A (2012) Atypical manifestations and poor outcome of herpes simplex encephalitis in the immunocompromised. Neurology 79:2125–2132. https://doi.org/10.1212/WNL.0b013e3182752ceb
Swinnen B, Saegeman V, Beuselinck K et al (2019) Predictive value of JC virus PCR in cerebrospinal fluid in the diagnosis of PML. Diagn Microbiol Infect Dis 95(3):114859. https://doi.org/10.1016/j.diagmicrobio.2019.06.011
Sonneville R, Venkatesan A, Honnorat J (2019) Understanding auto-immune encephalitis in the ICU. Intensive Care Med. https://doi.org/10.1007/s00134-019-05773-0
Tsai M-H, Lu C-H, Huang C-R et al (2006) Infection bacterial meningitis in young adults in Southern Taiwan: clinical characteristics and therapeutic outcomes. Infection. https://doi.org/10.1007/s15010-006-4144-6
Castelblanco RL, Lee MJ, Hasbun R (2014) Epidemiology of bacterial meningitis in the USA from 1997 to 2010: a population-based observational study. Lancet Infect Dis 14:813–819. https://doi.org/10.1016/S1473-3099(14)70805-9
Tunkel AR, Hasbun R, Bhimraj A et al (2017) 2017 Infectious diseases society of America’s clinical practice guidelines for healthcare-associated ventriculitis and meningitis. Clin Infect Dis 64:e34–e65. https://doi.org/10.1093/cid/ciw861
McClelland S, Guo H, Okuyemi KS (2011) Population-based analysis of morbidity and mortality following surgery for intractable temporal lobe epilepsy in the United States. Arch Neurol 68:725–729. https://doi.org/10.1001/archneurol.2011.7
Kourbeti IS, Vakis AF, Ziakas P et al (2015) Infections in patients undergoing craniotomy: risk factors associated with post-craniotomy meningitis. J Neurosurg 122:1113–1119. https://doi.org/10.3171/2014.8.JNS132557
Lozier AP, Sciacca RR, Romagnoli MF, Connolly ES (2002) Ventriculostomy-related infections: a critical review of the literature. Neurosurgery 51:170–182. https://doi.org/10.1227/01.NEU.0000017465.78245.6C
Citerio G, Signorini L, Bronco A et al (2015) External ventricular and lumbar drain device infections in icu patients: a prospective multicenter Italian study. Crit Care Med 43:1630–1637. https://doi.org/10.1097/CCM.0000000000001019
Ramanan M, Lipman J, Shorr A, Shankar A (2015) A meta-analysis of ventriculostomy-associated cerebrospinal fluid infections. BMC Infect Dis 14:1–12. https://doi.org/10.1186/s12879-014-0712-z
Jakobs M, Klein S, Eigenbrod T et al (2019) The siludrain trial: a prospective randomized controlled trial comparing standard versus silver-impregnated lumbar drains. J Neurosurg 1306:2040–2047. https://doi.org/10.3171/2018.1.JNS181522
Conen A, Walti LN, Merlo A et al (2008) Characteristics and treatment outcome of cerebrospinal fluid shunt-associated infections in adults: a retrospective analysis over an 11-year period. Clin Infect Dis 47:73–82. https://doi.org/10.1086/588298
Van De Beek D, De Gans J, Spanjaard L et al (2004) Clinical features and prognostic factors in adults with bacterial meningitis. N Engl J Med 351:1849–1859. https://doi.org/10.1056/NEJMoa040845
Thomas KE, Hasbun R, Jekel J, Quagliarello VJ (2002) The diagnostic accuracy of Kernig’s sign, Brudzinski’s sign, and nuchal rigidity in adults with suspected meningitis. Clin Infect Dis 35:46–52. https://doi.org/10.1086/340979
Penido Nde O, Borin A, Iha LC et al (2005) Intracranial complications of otitis media: 15 years of experience in 33 patients. Otolaryngol Head Neck Surg 132(1):37–42. https://doi.org/10.1016/j.otohns.2004.08.007
Sonneville R, Magalhaes E, Meyfroidt G (2017) Central nervous system infections in immunocompromised patients. Curr Opin Crit Care 23:128–133. https://doi.org/10.1097/MCC.0000000000000397
van de Beek D, de Gans J, Tunkel AR, Wijdicks EFM (2006) Community-acquired bacterial meningitis in adults. N Engl J Med 354:44–53. https://doi.org/10.1136/jnnp.2007.139725
Stahl JP, Azouvi P, Bruneel F et al (2017) Guidelines on the management of infectious encephalitis in adults. Med Mal Infect 47:179–194. https://doi.org/10.1016/j.medmal.2017.01.005
Tyler KL (2018) Acute viral encephalitis. N Engl J Med 379:557–566. https://doi.org/10.1056/NEJMra1708714
Sonneville R, Demeret S, Klein I et al (2008) Acute disseminated encephalomyelitis in the intensive care unit: clinical features and outcome of 20 adults. Intensive Care Med 34:528–532. https://doi.org/10.1007/s00134-007-0926-2
Graus F, Cellucci T, Cortese I et al (2016) A clinical approach to diagnosis of autoimmune encephalitis. Lancet Neurol 15:391–404. https://doi.org/10.1016/S1474-4422(15)00401-9.A
Cantier M, Morisot A, Guérot E et al (2018) Functional outcomes in adults with tuberculous meningitis admitted to the ICU: a multicenter cohort study. Crit Care 22:1–8. https://doi.org/10.1186/s13054-018-2140-8
Leber A, Everhart K, Demogines A et al (2015) Multi-center clinical evaluation of a multiplex meningitis / encephalitis pcr panel for simultaneous detection of bacteria, yeast, and viruses in cerebrospinal fluid specimens. J Clin Microbiol 54:2251–2261. https://doi.org/10.1128/JCM.00730-16.Editor
Brouwer MC, Tunkel AR, Van De Beek D (2010) Epidemiology, diagnosis, and antimicrobial treatment of acute bacterial meningitis. Clin Microbiol Rev 23:467–492. https://doi.org/10.1128/CMR.00070-09
Wilson MR, Sample HA, Zorn KC et al (2019) Clinical metagenomic sequencing for diagnosis of meningitis and encephalitis. N Engl J Med 380:2327–2340. https://doi.org/10.1056/NEJMoa1803396
Weisfelt M, Van De Beek D, Spanjaard L et al (2006) Clinical features, complications, and outcome in adults with pneumococcal meningitis: a prospective case series. Lancet Neurol 5:123–129. https://doi.org/10.1016/S1474-4422(05)70288-X
Chow FC, Glaser CA, Sheriff H et al (2015) Use of clinical and neuroimaging characteristics to distinguish temporal lobe herpes simplex encephalitis from its mimics. Clin Infect Dis 60:1377–1383. https://doi.org/10.1093/cid/civ051
Sutter R, Kaplan PW, Cervenka MC et al (2015) Electroencephalography for diagnosis and prognosis of acute encephalitis. Clin Neurophysiol 126:1524–1531. https://doi.org/10.1016/j.clinph.2014.11.006
Bodilsen J, Dalager-Pedersen M, Schønheyder HC, Nielsen H (2016) Time to antibiotic therapy and outcome in bacterial meningitis: a Danish population-based cohort study. BMC Infect Dis. https://doi.org/10.1186/s12879-016-1711-z
Bretonnière C, Jozwiak M, Girault C et al (2015) Rifampin use in acute community-acquired meningitis in intensive care units: the French retrospective cohort ACAM-ICU study. Crit Care 19:1–9. https://doi.org/10.1186/s13054-015-1021-7
Bouadma L, Schortgen F, Thomas R et al (2006) Adults with spontaneous aerobic Gram-negative bacillary meningitis admitted to the intensive care unit. Clin Microbiol Infect 12:287–290. https://doi.org/10.1111/j.1469-0691.2005.01346.x
Teckie G, Karstaedt A (2015) Spontaneous adult Gram-negative bacillary meningitis in Soweto, South Africa. Int J Infect Dis 30:e38–e40. https://doi.org/10.1016/j.ijid.2014.10.006
Bodilsen J, Brouwer MC, Kjærgaard N et al (2018) Community-acquired meningitis in adults caused by Escherichia coli in Denmark and The Netherlands. J Infect. https://doi.org/10.1016/j.jinf.2018.05.009
Rhodes A, Evans LE, Alhazzani W et al (2017) Surviving sepsis campaign: international guidelines for management of sepsis and septic shock: 2016. Intensive Care Med 43:304–377. https://doi.org/10.1007/s00134-017-4683-6
van de Beek D, Drake JM, Tunkel AR (2010) Nosocomial Bacterial Meningitis. N Engl J Med 362:146–154. https://doi.org/10.1056/NEJMra0804573
Brouwer MC, Mcintyre P, Prasad K, van de Beek D (2015) Corticosteroids for acute bacterial meningitis. Cochrane Database Syst Rev. https://doi.org/10.1002/14651858.CD004405.pub5
Gallegos C, Tobolowsky F, Nigo M, Hasbun R (2018) Delayed cerebral injury in adults with bacterial meningitis. Crit Care Med 46:e811–e814. https://doi.org/10.1097/ccm.0000000000003220
Solomon T, Michael BD, Smith PE et al (2012) Management of suspected viral encephalitis in adults—association of British neurologists and British infection association national guidelines. J Infect 64:347–373. https://doi.org/10.1016/j.jinf.2011.11.014
Hussein K, Rabino G, Feder O et al (2019) Risk factors for meningitis in neurosurgical patients with cerebrospinal fluid drains: prospective observational cohort study. Acta Neurochir (Wien) 161:517–524. https://doi.org/10.1007/s00701-019-03801-y
Garnacho-Montero J, Dimopoulos G, Poulakou G et al (2015) baumannii infections in the ICU. Intensive Care Med 41:2057–2075
Falagas ME, Bliziotis IA (2007) Pandrug-resistant Gram-negative bacteria: the dawn of the post-antibiotic era? Int J Antimicrob Agents 29:630–636. https://doi.org/10.1016/j.ijantimicag.2006.12.012
Katragkou A, Roilides E (2005) baumannii central nervous system infections with colistin [2]. J Clin Microbiol 43:4916–4917. https://doi.org/10.1128/JCM.43.9.4916-4917.2005
Kim BN, Peleg AY, Lodise TP et al (2009) Management of meningitis due to antibiotic-resistant Acinetobacter species. Lancet Infect Dis 9:245–255. https://doi.org/10.1016/S1473-3099(09)70055-6
Motta I, Calcagno A, Bonora S (2018) Pharmacokinetics and pharmacogenetics of anti-tubercular drugs: a tool for treatment optimization? Expert Opin Drug Metab Toxicol 14:59–82. https://doi.org/10.1080/17425255.2018.1416093
Nierenberg NE, Thompson GR, Lewis JS et al (2010) Voriconazole use and pharmacokinetics in combination with interferon-γ for refractory cryptococcal meningitis in a patient receiving low-dose ritonavir. Med Mycol 48:532–536. https://doi.org/10.3109/13693780903325282
Beach JE, Perrott J, Turgeon RD, Ensom MHH (2017) Penetration of vancomycin into the cerebrospinal fluid: a systematic review. Clin Pharmacokinet 56:1479–1490. https://doi.org/10.1007/s40262-017-0548-y
Le Turnier P, Navas D, Garot D et al (2019) Tolerability of high-dose ceftriaxone in CNS infections: a prospective multicentre cohort study. J Antimicrob Chemother 74:1078–1085. https://doi.org/10.1093/jac/dky553
Ng K, Mabasa VH, Chow I, Ensom MHH (2014) Systematic review of efficacy, pharmacokinetics, and administration of intraventricular vancomycin in adults. Neurocrit Care 20:158–171. https://doi.org/10.1007/s12028-012-9784-z
Tafelski S, Wagner L, Angermair S, Deja M (2017) Therapeutic drug monitoring for colistin therapy in severe multi-resistant Acinetobacter intracerebral abscess: a single case study with high-dose colistin and review of literature. SAGE Open Med Case Rep 5:2050313X1771163. https://doi.org/10.1177/2050313x17711630
Fernando S, Tran A, Cheng W et al (2019) Diagnosis of elevated intracranial pressure in critically ill adults—a systematic review and meta-analysis. BMJ 366:1–10. https://doi.org/10.1017/cem.2019.142
Glimåker M, Johansson B, Halldorsdottir H et al (2014) Neuro-intensive treatment targeting intracranial hypertension improves outcome in severe bacterial meningitis: an intervention-control study. PLoS ONE ONE 9:e91976. https://doi.org/10.1371/journal.pone.0091976
Tariq A, Aguilar-Salinas P, Hanel RA et al (2017) The role of ICP monitoring in meningitis. Neurosurg Focus 43:1–7. https://doi.org/10.3171/2017.8.FOCUS17419
Pelkonen T, Roine I, Cruzeiro ML et al (2011) Slow initial β-lactam infusion and oral paracetamol to treat childhood bacterial meningitis: a randomised, controlled trial. Lancet Infect Dis 11:613–621. https://doi.org/10.1016/S1473-3099(11)70055-X
Molyneux EM, Kawaza K, Phiri A et al (2014) Glycerol and acetaminophen as adjuvant therapy did not affect the outcome of bacterial meningitis in malawian children. Pediatr Infect Dis J 33:214–216. https://doi.org/10.1097/INF.0000000000000122
Mourvillier B, Tubach F, Van De Beek D et al (2013) Induced hypothermia in severe bacterial meningitis: a randomized clinical trial. JAMA J Am Med Assoc 310:2174–2183. https://doi.org/10.1001/jama.2013.280506
Cabellos C, Verdaguer R, Olmo M et al (2009) Community-acquired bacterial meningitis in elderly patients: experience over 30 years. Medicine (Baltimore) 88:115–119. https://doi.org/10.1097/MD.0b013e31819d50ef
Zoons E, Weisfelt M, de Gans J et al (2008) Seizures in adults with bacterial meningitis. Neurology 70:2109–2115. https://doi.org/10.1212/01.wnl.0000288178.91614.5d
Larsen FTBD, Brandt CT, Larsen L et al (2019) Risk factors and prognosis of seizures in adults with community-acquired bacterial meningitis in Denmark: Observational cohort studies. BMJ Open 9:1–9. https://doi.org/10.1136/bmjopen-2019-030263
Pandey S, Rathore C, Michael BD (2016) Antiepileptic drugs for the primary and secondary prevention of seizures in viral encephalitis. Cochrane Database Syst Rev. https://doi.org/10.1002/14651858.CD010247.pub3
Peltola H, Roine I, Fernandez J et al (2007) Adjuvant glycerol and/or dexamethasone to improve the outcomes of childhood bacterial meningitis: a prospective, randomized, double-blind, placebo-controlled trial. Clin Infect Dis 45:1277–1286. https://doi.org/10.1086/522534
Ajdukiewicz KMB, Cartwright KE, Scarborough M et al (2011) Glycerol adjuvant therapy in adults with bacterial meningitis in a high HIV seroprevalence setting in Malawi: a double-blind, randomised controlled trial. Lancet Infect Dis 11:293–300. https://doi.org/10.1016/S1473-3099(10)70317-0
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GM is funded by the Research Foundation, Flanders (FWO), as senior clinical investigator (1843118 N) and receives project research funding from the KU Leuven (C24/17/072); he has received consultancy and lecture fees from Codman. RS received grants from the French Ministry of Health, the French Society of Intensive Care Medicine (SRLF) and the European Society of Intensive Care Medicine (ESICM), and lecture fees from Baxter.
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Meyfroidt, G., Kurtz, P. & Sonneville, R. Critical care management of infectious meningitis and encephalitis. Intensive Care Med 46, 192–201 (2020). https://doi.org/10.1007/s00134-019-05901-w
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DOI: https://doi.org/10.1007/s00134-019-05901-w